Electronic Resource
Miyakawa, T.
;
Togawa, Y.
;
Matushima, H.
;
[et al.]
Nakamura, H.
;
Kamada, N.
;
Momota, Y.
;
Tochigi, N.
;
Nikaido, T.
;
Shinkai, H.
;
Utani, A.
Oxford, UK
:
Blackwell Science Ltd
Clinical and experimental dermatology
29 (2004), S. 0
ISSN:
1365-2230
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A patient had triple extramammary Paget's disease of both axillary and genital regions. Right inguinal lymphadenopathy was found 1 year after excision of all the skin lesions. Excisional biopsy of the lymph node demonstrated a mixture of Paget cells and atypical squamoid cells with horn pearls suggestive of keratinization. The squamoid cells were positive for cytokeratin 10, a marker of suprabasal epidermis, and also positive for laminin γ2 which is often expressed in invasive squamous cell carcinoma. The coexistence of these different cells within the same tumour island suggested that the squamoid cells derived from metaplasia of Paget cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2230.2004.01425.x
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