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  • 1
    Electronic Resource
    Electronic Resource
    Epitaxial Y-Ba-Cu-O thin films prepared by rf-magnetron sputtering (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 1318-1322 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Superconducting Y-Ba-Cu-O thin films were prepared by a rf-magnetron sputtering process. The preparation conditions, film crystallinity, and resistivity were investigated. The composition of the films strongly depended on the oxygen partial pressure of the sputtering gas. It was found that the substrate temperature during sputtering and the selection of substrate materials governed the crystallinity of the Y-Ba-Cu-O thin films. The preferential c-axis orientation was obtained for the films prepared on (0112) sapphire, (100) MgO, and (100) SrTiO3 substrates at a substrate temperature of about 750 °C. These as-deposited films have shown the superconducting transitions which were improved by setting the optimum conditions for sputtering and subsequent anneal process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.341853
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  • 2
    Electronic Resource
    Electronic Resource
    Piezoelectric properties of c-axis oriented Pb(Zr,Ti)O3 thin films (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 1378-1380 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Piezoelectric properties of the c-axis oriented Pb(Zr,Ti)O3 (PZT) thin films were investigated. The PZT films with a composition near the morphotropic phase boundary were epitaxially grown on (100)Pt-coated MgO substrates by rf-magnetron sputtering. The PZT films exhibited excellent ferroelectricity with a remanent polarization more than 50 μC/cm2. In order to examine intrinsic piezoelectric properties, cantilever structures were microfabricated with the PZT films. The piezoelectric coefficient d31 of PZT films, which were not subjected to poling treatments, was measured directly from the transverse expansion of the cantilever beams. The measurements revealed that the PZT films were naturally polarized and had a relatively large piezoelectric coefficient d31 of 100×10−12 m/V without poling. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.118583
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  • 3
    Electronic Resource
    Electronic Resource
    Evanescent wave absorption by Xe(1s5) lying on a discharge tube wall (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 2333-2335 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A simple and sensitive detection method of Xe(1s5) excited atoms in the vicinity of a discharge wall with laser-collision induced fluorescence (LCIF) produced by evanescent wave absorption is proposed. The signal to noise (S/N) ratio was 102. The hyperfine structure (hfs) in the Xe LCIF spectra induced by resonant absorption of Xe(1s5→2p6) was confirmed to be identical with the hfs in laser absorption spectra, although the detection point (xPD) on the discharge wall was chosen independently of the position of the EW absorption (xEW). The insignificantly large fluorescence, which appeared for incident light angles to a prism larger than 4.8°, is explained by the fact that the refracted light emerged in a plasma. The Xe(1s5) number density in a dc Xe discharge, although roughly estimated, on the tube wall between the electrodes is presented. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1409274
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of Carcinoplacental Alkaline Phosphatase by Polyacrylamide Gradient Gel Electrophoresis (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 8 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Human serum alkaline phosphatase (E.C. 3.1.3.1.) was subclassified into several isoenzymes including carcinoplacental alkaline phosphatase isoenzyme (CPALP) by electrophoretic procedures. Since CPALP has three subtypes, such as Regan, Nagao and Variant type, their properties are somewhat different among them, and have no specific property, no simple method has yet been ascertained to detect CPALP separately.CPALP was detected as the fastest migrating isoenzyme band to the anode, using the polyacrylamide gel electrophoresis of more than 8.0% gel concentration. Thus, a polyacrylamide gradient gel electrophoresis of 16–8% gel concentration in Tris-borate buffer system was introduced, which resulted in CPALP being found to be the fastest migrating isoenzyme band to the anode and microheterogeneities of each CPALP were also identified: CPALP (Variant) was electrophoresed rather faster to the anode, CPALP (Nagao); intermediate, and CPALP (Regan), as well as placental alkaline phosphatase isoenzyme; rather slower. In addition, each isoenzyme of CPALP and placental alkaline phosphatase further differentiated clearly into a few subbands.Slow moving new bands appeared by Triton X-100 treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb03971.x
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  • 5
    Electronic Resource
    Electronic Resource
    A sensitive method for the quantitative estimation of cytochromes a and a"3 in tissues
    Amsterdam : Elsevier
    Analytical Biochemistry 74 (1976), S. 105-117 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(76)90313-4
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  • 6
    Electronic Resource
    Electronic Resource
    The specific expression of Hypoxia Inducible Factor-1α in human gastric mucosa induced by nonsteroidal anti-inflammatory drugs (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 18 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Hypoxia is a cause of gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The expression of hypoxia inducible factor-1α (HIF-1α) reflects the status of tissue ischaemia.Aim : To investigate the effect of NSAID administration on the expression of HIF-1α in human gastric mucosa.Methods : We employed 71 patients including 14 with NSAID administration. The HIF-1α expression was estimated by immunohistochemistry using monoclonal antibody (H1α67) and raised antiserum (HI-3). Vascular endothelial growth factor expression was also examined by immunohistochemistry. HI-3 recognized hypoxia-induced protein in HeLa cells.Results : In human gastric mucosa, HIF-1α was mainly expressed in the nuclei of the surface epithelial cells and in the neck zone both by use of HI-3 and of H1α67. The expression of vascular endothelial growth factor correlated well with that of HIF-1α. The level of HIF-1α in the surface epithelium was significantly higher in patients with administration of NSAIDs than those without NSAID use (P 〈 0.001) both in the gastric corpus and antrum. Helicobacter pylori infection did not affected the levels of HIF-1α. Long-term administration of rebamipide reduced the level of HIF-1α.Conclusion : HIF-1α expression is a new biological marker of ischaemia especially in NSAID-related gastric lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.18.s1.10.x
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  • 7
    Electronic Resource
    Electronic Resource
    Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of Helicobacter pylori in smokers (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Our previous study demonstrated that Helicobacter pylori eradication was less effective in smokers than in non-smokers. Cetraxate is an anti-ulcer drug that increases gastric mucosal blood flow.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To evaluate the effect of cetraxate combined with new triple therapy for the eradication of H. pylori in smokers.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:This study had a single-centre, double-blind, randomized non-placebo design. A total of 106 consecutive H. pylori-positive smoking patients were randomly allocated to one of two regimens: one group received omeprazole (20 mg), amoxycillin (1500 mg), and clarithromycin (600 mg) for 7 days (OAC, n=55). The other group recieved OAC plus cetraxate (600 mg) for 7 days (OAC + CET, n=51). The success of H. pylori eradication was evaluated by histology and the 13C-urea breath test at 4 weeks after completion of treatment.〈section xml:id="abs1-4"〉〈title type="main"〉Results:By intention-to-treat analysis, the H. pylori eradication rate was 55% in the OAC group and 92% in the OAC + CET group (P 〈 0.01). By per protocol analysis, the H. pylori eradication rate was 58% in the OAC group and 94% in the OAC + CET group (P 〈 0.01).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:Cetraxate combined with new triple therapy increases the eradication of H. pylori in smokers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00807.x
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  • 8
    Electronic Resource
    Electronic Resource
    Famotidine prevents canine gastric blood flow reduction by NSAIDs (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To investigate the effect of famotidine on gastric blood flow reduction induced by diclofenac sodium, a common non-steroidal anti-inflammatory drug in Japan, using laser Doppler flowmetry in the canine stomach.Methods : The gastric mucosal blood flow was measured by laser Doppler flowmetry in 15 healthy male beagles before and 60 min after the administration of diclofenac suppository (1.0 mg/kg) into the rectum. The examination was done in a crossover, single-blinded fashion. All dogs underwent both famotidine (0.5 mg/kg) and placebo (saline) injection simultaneously with the administration of diclofenac. In addition, the tissue concentration of prostaglandin E2 was measured.Results : The blood flow decreased by 18.3 ± 9.1% in the gastric body, by 26.3 ± 8.1% in the antrum in the placebo group after the administration of diclofenac sodium, while the decreases seen were significantly smaller in the famotidine group: 3.2 ± 12.6% in the gastric body and 7.9 ± 16.5% in the antrum (P = 0.001 for the gastric body, P = 0.0034 for the antrum). Conversely, the percentage of mucosal prostaglandin E2 concentration decrease in each group did not show a significant difference.Conclusion : Famotidine alleviates the reduction of gastric blood flow induced by diclofenac sodium. Further, not only mucosal prostaglandins but also gastric acid may play an important role in non-steroidal anti-inflammatory drugs-induced gastric microcirculatory disturbance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02475.x
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim:  We investigated the effect of acid suppression therapy on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer.Methods:  A total of 400 patients with bleeding peptic ulcer received either intravenous infusion of famotidine (40 mg/day) (n = 207, 163 males, 44 females, mean age 61.5 years) or drip infusion of omeprazole (40 mg/day; n = 193, 134 males, 59 females, mean age 59.8 years) after successful endoscopic treatment. The fasting duration, hospital stay, volume of transfused blood, incidence of rebleeding and mortality were compared between the two groups.Results:  The incidence of rebleeding did not differ significantly between the famotidine group (9%) and the omeprazole group (8%). The mean hospital stay was significantly shorter in the omeprazole group (18.4 days) than in the famotidine group (21.5 days, P = 0.009). However, there was no statistically significant difference in fasting duration, volume of transfused blood or mortality.Conclusion:  Our findings indicate that intravenous infusion of famotidine after successful endoscopic treatment is equivalent to drip infusion of omeprazole for prevention of recurrent bleeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02478.x
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Recent studies showed that acid-suppressive therapy aggravates corpus gastritis in patients with Helicobacter pylori infection.Aim : The aim of this study was to evaluate the effect of famotidine, a histamine receptor antagonist on corpus gastritis in patients with peptic ulcer disease.Methods : We enrolled 287 patients, 173 with duodenal ulcer and 114 with gastric ulcer and 100 patients with H. pylori-positive gastritis as control subjects. Patients with peptic ulcer were classified according to whether or not they received famotidine-maintenance therapy (20 mg/day) after primary treatment. At the time of endoscopy, biopsy specimens were obtained from the antrum and the corpus. The degrees of neutrophil and lymphocyte infiltration, atrophy and intestinal metaplasia were scored according to the updated Sydney System.Results : The degrees of neutrophil infiltration and atrophy in the corpus were significantly less in patients with gastric ulcer or duodenal ulcer than in patients with H. pylori-positive gastritis (P 〈 0.01). Differences in the degrees of neutrophil infiltration and atrophy in the corpus between the non-maintenance group and the maintenance group were not significant.Conclusion : Long-term therapy with famotidine does not appear to lead to an increase in the incidence of corpus gastritis or corpus atrophy in patients with peptic ulcer disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02482.x
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