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  • 1
    Electronic Resource
    Electronic Resource
    Molecular cloning of proteinase-encoding genes from cancer cells by zymogen assay and direct sequencing
    Amsterdam : Elsevier
    Analytical Biochemistry 191 (1990), S. 235-241 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(90)90213-S
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of picomole amounts of lipoxins C"4, D"4 and E"4 by high-performance liquid chromatography with electrochemical detection
    Amsterdam : Elsevier
    Journal of Chromatography A 585 (1991), S. 53-56 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0021-9673(91)85056-L
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  • 3
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1992)
    Springer
    Helgoland marine research 46 (1992), S. 447-452 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02367210
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of three bacteria strains on the population dynamics ofTisbe holothuriae (Copepoda, Harpacticoida) (1991)
    Springer
    Helgoland marine research 45 (1991), S. 493-511 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The influence of three bacteria strains (Helgo 21, NCMB 308 and NCMB 13) on the life cycle ofTisbe holothuriae Humes 1957 was investigated under constant experimental conditions (19–20°C and 38‰ S). For each of the first six experiments, females (F1), whose life history was followed, were obtained from a common mother (F0). Experiment no 7 was carried out with adult females (F2) obtained during exp. 4. Females were bred in 50-ml dishes and transferred to a fresh container as soon as they produced a new egg-sac. Offspring (F2: exp. 1–6; F3: exp. 7) from successive egg-layings were counted as soon as they moulted into adults. Larval mortality was estimated by enumeration of the adults issuing from a known number of nauplii that had been fed different bacteria strains. Some difficulties arose in obtaining adults with NCMB 13: it appeared to be necessary to provide this first generation with a small quantity of TetraMin (commercial fish food) in order to initiate reproduction and obtain a second generation. However, in exp. 4, F2 adult females fed NCMB 13 became ovigerous and fertile without needing TetraMin. This result is interpreted as denoting an indispensable period of adaptation to the diet, which probably requires important changes at the enzymatic level. One experiment was carried out with Helgo 21; another one with NCMB 308; two with NCMB 13 (with a unique additional meal of TetraMin to allow reproduction), two with NCMB 13 during larval development, then only tetraMin during adult stage, and one with NCMB 13 alone (with females issued from exp. 4). Data obtained regarding longevity, duration of reproduction period, number of egg-sacs and number of adult descendants show an important variability between bacteria strains. Lower results were almost always obtained with Helgo 21 and NCMB 308. An interesting result lies in the maximum number of egg-sacs: low with Helgo 21 and NCMB 308 (5), but very ample with NCMB 13 (11 in one experiment). In experiment 7, carried out with animals bearing a large coefficient of inbreeding (0.375), the results concerning the maximum number of egg-sacs are good (10) as are the mean number of descendants per female (294: the highest number of the seven experiments). These results indicate that genetic factors involved in the reduction of descendants in ageing laboratory cultures can be suppressed to a certain extent by nutritional factors. The poor results obtained with Helgo 21 and NCMB 308 alone must be considered with caution: after a period of adaptation with an alimentary complement, these strains could perhaps permit an interesting production of copepods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02367181
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  • 5
    Electronic Resource
    Electronic Resource
    Macroalgal decomposition: Laboratory studies with particular regard to microorganisms and meiofauna (1990)
    Springer
    Helgoland marine research 44 (1990), S. 397-410 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The microbial degradation of North Sea macroalgae was studied in laboratory microcosms, containing autoclaved seawater and a mixture of equal parts of air-driedDelesseria sanguinea, Ulva lactuca, andLaminaria saccharina (red, green and brown algae, respectively). To determine the influence of different organisms on the decomposition rate (expressed in terms of algal dry weight loss relative to the material present at time zero) and their development during decomposition processes, yeast, flagellates, ciliates, nematodes and a harpacticoid copepod species were introduced to the microcosms. Results show that microbial degradation compared to the controls was enhanced in the presence of non-axenic nematodes (Monhystera sp.) and protozoans, including bacterivorous ciliates (Euplotes sp. and aUronema-like sp.) and flagellates. No enhancement occurred with yeast (Debaryomyces hansenii) or with the harpacticoid copepodTisbe holothuriae. The most rapid algal dry weight loss (78.7% after 14 d at 18°C) occurred with the addition of raw seawater sampled near benthic algal vegetation and containing only the natural microorganisms present. These consisted mainly of bacteria with different morphological properties, whereby their numbers alone (viable counts) could not be correlated with algal dry weight loss. Although no single dominant species could be determined, lemon yellow pigmented colonies were frequently found. During decomposition in all microcosms the formation of algal particles 40–400 μm was observed, which were rapidly colonized by the other organisms present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02365476
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  • 6
    Electronic Resource
    Electronic Resource
    Dose-effect relationships in 60 children with leukemia and other malignancies under cytostatic therapy. Cytogenetic analysis
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 46 (1977), S. 225 
    Details
    ISSN: 0165-1161
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1161(77)90075-9
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  • 7
    Electronic Resource
    Electronic Resource
    Die Rolle des postoperativen Hirngefäßspasmus nach Verklippung intrakranieller Aneurysmen (1978)
    Springer
    Acta neurochirurgica 40 (1978), S. 55-60 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After clipping of intracranial aneurysms, postoperative vasospasm may occur remote from the distribution area of the artery and may cause death. The authors report two cases and give the clinical, neuroradiological, and neuroanatomical findings.
    Notes: Zusammenfassung Nach Verklippung intrakranieller Aneurysmen kann es postoperativ infolge arterieller Spasmen zu tödlich verlaufender Infarzierung kommen, die nicht im Versorgungsbereich der geklippten Arterie liegt. Es werden zwei derartige Fälle mitgeteilt unter Würdigung klinischer, neuroradiologischer und neuroanatomischer Befunde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01773115
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  • 8
    Electronic Resource
    Electronic Resource
    Einfluß von Pockenimpfviren auf menschliche Chromosomen in vivo und in vitro (1968)
    Springer
    Human genetics 〈Berlin〉 6 (1968), S. 55-60 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Menschliche Lymphocyten, die am 6., 9. und 12. Tag nach Pockenschutzimpfung kultiviert wurden, zeigten keine sicher verwertbaren Chromosomenanomalien. Nach Infektion menschlicher Lymphocytenkulturen hemmt Vaccinevirus die Mitosen und zerstört die Zellen in toto parallel zur Dauer der Einwirkung. Numerische und strukturelle Veränderungen an den Chromosomen wurden nicht beobachtet.
    Notes: Summary Contradictory views are expressed in the literature on the question as to whether viruses induce anomalies in chromosomes. Vaccinia viruses in particular are generally stated to cause chromatid and chromosome breakage in L-cells (human embryonal lung tissue). The subject of the present paper is an experimental investigation of the effect of vaccinia viruses on the chromosomes of human blood lymphocytes. In the in vivo portion of this investigation the chromosomes were examined during and after viremia subsequent to vaccination. Only two of the eight vaccinated children examined showed a larger number of chromosome breaks during viremia than unvaccinated controls. This might possibly be due to different degrees of viremia, although local and general reactions were the same. Other causes might also be sought in vivo or in vitro, such as preparation of the chromosomes, or an unnoted mycoplasma infection of the lymphocyte cultures. In the in vitro portion of this investigation, cultures of human lymphocytes were infected with vaccinia viruses at different stages of incubation. In culture the virus concentrations exhibited a rapid initial decrease, which gradually tapered off during the period of observation. No increases in virus concentration were noted. The longer the period of infection with caccinia virus, the less growth shown by the lymphocytes, and the more mitotic cells with in toto destruction of the chromosome. Anomalies in individual chromosomes were not observed any more frequently than in controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00287154
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  • 9
    Electronic Resource
    Electronic Resource
    Renal polyamine excretion, tubular amino acid reabsorption and molecular genetics in cystinuria (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 376-384 
    Details
    ISSN: 1432-198X
    Keywords: Key words Tubular amino acid reabsorption ; Renal polyamine excretion ; SLC3A1 mutation analysis ; Genetic localization of non-type I cystinuria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cystinuria is an autosomal recessive disorder of the tubular and intestinal resorption of cystine, ornithine, lysine and arginine leading to nephrolithiasis. Three cystinuria types can be distinguished by the mode of inheritance (true recessive or intermediate) and by the pattern of the intestinal amino acid transport. In the present study phenotypes were assessed by the urinary excretion of amino acids related to creatinine, the percentage tubular amino acid reabsorption and the urinary excretion of polyamines as a possible indicator of the intestinal transport defect. However, our thorough phenotyping did not reveal more than two cystinuria types. Genotypes were examined in linkage analyses and single-strand conformation polymorphism-based mutation identification. The SLC3A1 mutations M467T and T216M were disease causing in our homozygous patients of type I cystinuria. We can show the association of type I cystinuria with SLC3A1 and of non-type I cystinuria with a yet unidentified gene on chromosome 19q13.1. Our phenotype and genotype analyses provide evidence for only two types of cystinuria in the investigated patient cohort.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050778
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  • 10
    Electronic Resource
    Electronic Resource
    A search for chromosome 22q11.2 deletions in a series of 176 consecutively catheterized patients with congenital heart disease: no evidence for deletions in non-syndromic patients (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 958-963 
    Details
    ISSN: 1432-1076
    Keywords: Key words Chromosome 22q11.2 microdeletion ; Isolated congenital heart disease ; AbbreviationsAS aortic stenosis ; ASD atrial septal defect ; CHD congenital heart disease ; CoA coarctation of the aorta ; CTAFS conotruncal anomaly face syndrome ; DGS DiGeorge syndrome ; FISH fluorescence in situ hybridization ; PA pulmonary atresia ; PDA patent ductus arteriosus ; PS pulmonary stenosis ; SAS subaortic stenosis ; SPS subpulmonary stenosis ; TGA transposition of the great arteries ; TOF tetralogy of Fallot ; VCFS velo-cardio-facial syndrome ; VSD ventricular septal defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Microdeletions in chromosome 22q11.2 are associated with DiGeorge syndrome (DGS), velo-cardio-facial syndrome (VCFS), and several other syndromes, collectively referred to as DG/VCF. Non-dysmorphic patients with cardiac defects have also been attributed to deletions in this chromosomal region. In this study 157 consecutively catheterized patients with isolated, non-syndromic cardiac defects, and 25 patients with cardiac defects and additional stigmata (10 of whom were clinically diagnosed as DG/VCF cases prior to chromosome analysis) were analysed by fluorescence in situ hybridization with the DGS-specific probe D0832. Chromosome 22q11.2 deletions were observed only in the ten patients with the clinical diagnosis of DG/VCF. Conclusion In a large unselected cohort of patients with congenital heart disease no association between isolated or non-syndromic heart defects and the 22q11.2 microdeletion was observed. One can conclude that testing for the 22q11.2 microdeletion is clearly indicated in cases when even mild extracardiac abnormalities are present, particularly in very young infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051257
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