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  • 1
    Electronic Resource
    Electronic Resource
    Detection of all anti-factor VIII antibodies in haemophilia A patients by the Bethesda assay and a more sensitive immunoprecipitation assay (2001)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 7 (2001), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Plasmas from 40 haemophilia A patients enrolled in a study by the paediatric group of the German Society on Thrombosis and Hemostasis were tested by the Bethesda assay for inhibitor antibodies and by a more sensitive immunoprecipitation assay (IP) for all antifactor VIII antibodies. Of the 26 severe, 11 moderate and three mild haemophiliacs, 18, two, and none, respectively, had positive Bethesda titres after several factor VIII infusions. In 275 plasmas with Bethesda titres of 0, 0.6–1.0, 〉 1–5, and 〉 5–655, the IP responses were 0–238, 0–61, 0–786, and 43–6141, respectively, and a reliable positive IP titre was 〉 4.2. The overlapping ranges of IP titres indicated large differences in the ratio of inhibitory to noninhibitory antibodies in individual plasmas. In five of seven patients with Bethesda titres of 0.6–1, the IP titres were 〈 4.2, suggesting a lack of precision of Bethesda titres ≤ 1. Detection of the primary immune response was found in only three patients by IP assay before a positive Bethesda assay. This precludes early, reliable testing of which patients will be immunologically responsive. In four patients undergoing immune tolerance therapy, antifactor VIII antibodies were still detectable by the IP assay in the absence of a Bethesda titre, which indicates that antibodies were completely eradicated in none of the patients. Our results show that the use of both the Bethesda and IP assays can provide more accurate detection of antifactor VIII antibodies in all patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2001.00456.x
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  • 2
    Electronic Resource
    Electronic Resource
    Combined process modeling and subthreshold device simulation
    Amsterdam : Elsevier
    Solid State Electronics 29 (1986), S. 371-375 
    Details
    ISSN: 0038-1101
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0038-1101(86)90217-0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Emitter-base breakdown: Measurement and simulation
    Amsterdam : Elsevier
    Microelectronic Engineering 19 (1992), S. 695-698 
    Details
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(92)90524-U
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrashallow emitter-base profiles by double diffusion
    Amsterdam : Elsevier
    Microelectronic Engineering 19 (1992), S. 347-350 
    Details
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(92)90451-V
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    BICMOS-The technology for integrating systems onto one silicon IC
    Amsterdam : Elsevier
    Microelectronic Engineering 15 (1991), S. 501-512 
    Details
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(91)90272-F
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  • 6
    Electronic Resource
    Electronic Resource
    Borosilicate glass and its applications in bipolar technology
    Amsterdam : Elsevier
    Microelectronic Engineering 15 (1991), S. 525-528 
    Details
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(91)90276-J
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  • 7
    Electronic Resource
    Electronic Resource
    Protonenresonanz-spektroskopie ungesattigter ringsysteme-IX - Die partielle analyse einiger bullvalen-spektren-ein beitrag zum problem der inneren rotation bei vinylcyclopropanen
    Amsterdam : Elsevier
    Tetrahedron 25 (1969), S. 1531-1543 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)82726-5
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  • 8
    Electronic Resource
    Electronic Resource
    Ludwig Rehn (1930)
    Springer
    Journal of molecular medicine 9 (1930), S. 1335-1335 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01739466
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Red cell aggregation in blood flow (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 149-157 
    Details
    ISSN: 1432-1440
    Keywords: Blutrheologie ; arterielle Verschlußkrankheiten ; Diabetes mellitus ; Myelom ; photometrische Aggregometrie ; Rouleaux-Bildung ; Rouleaux-Klumpen ; Rouleaux-Netzwerke ; scheinbare Blutviskosität ; Schwangerschaft ; Apparent blood viscosity ; arterial vascular disease ; blood rheology ; diabetes mellitus ; myeloma ; photometric aggregometry ; pregnancy ; rouleaux clumps ; rouleaux formation ; rouleaux networks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The rheological behavior of normal and pathological red cell aggregates in viscometric flow (artificial flow in cone plate chamber) is studied by direct microscopy, (rheoscopy) viscometry and photometry. Marked differences between normal and pathological blood are measured in the microrheological properties of red cell aggregates; only discreet differences are measured by blood viscometry (macrorheology). Both in normal and abnormal blood, red cell aggregation is a reversible process in the presence of adequate shear forces; their respective influences on apparent blood viscosity at low rates of shear are complex functions of shear rate, shear time, hematocrit and plasma viscosities. Pathological red cell aggregation (RCA) forms more rapidly and extensively than normal RCA. The pathological aggregates frequently have a tendency to grow at low rates of shear and they are highly shear resistant.
    Notes: Zusammenfassung Das rheologische Verhalten von normalen und pathologischen Erythrocytenaggregaten in viskometrischer Strömung (künstliche Strömung in Platte-Kegel-Kammer) wird mittels direkter mikroskopischer Beobachtung (im „Rheoskop“), Viskometrie und Photometrie untersucht. Erhebliche Unterschiede finden sich bei dem mikrorheologischen Verhalten, während im makrorheologischen Verhalten (Blut-Viskometrie) nur diskrete und oft komplexe Differenzen zwischen normalen und pathologischem Blut gemessen werden. Sowohl im normalen wie im pathologischen Blut ist die Erythrocytenaggregation ein reversibler Prozeß, vorausgesetzt, daß ausreichende Scherkräfte vorhanden sind. Der Einfluß der normalen und pathologischen Aggregate ist eine komplexe Funktion des Schergrades, der Scherzeit, des Hämatokritwertes und der Plasmaviskosität. Pathologische Erythrocytenaggregate bilden sich schneller und extensiver aus als normale Aggregate. Sie haben oft eine Tendenz, bei langsamer Strömung zu wachsen und sind hochgradig scherungsresistent:
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468879
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  • 10
    Electronic Resource
    Electronic Resource
    Red cell aggregation in blood flow (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 159-167 
    Details
    ISSN: 1432-1440
    Keywords: Blutrheologie ; Fahraeus-Effekt ; Rouleaux-Klumpen ; Rouleaux-Netzwerke ; scheinbare Blutviskosität ; scheinbare relative Blutviskosität ; Viscosimetrie ; Apparent blood viscosity ; blood rheology ; Fahraeus-effect ; relative apparent blood viscosity ; rouleaux clumps ; rouleaux networks ; viscometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The apparent viscosity of blood strongly increases at low shear in rotational viscometers, this phenomenon is based on the reversible formation of red cell aggregates. The magnitude of this increase strongly depends on the hematocrit value, on plasma viscosity and lastly on the microrheological properties of the aggregates. The independent measurement of the microrheological behavior and the effects on viscosity allows a detailed analysis of the hemodynamic effects of red cell aggregates under defined flow conditions in vivo. The comparative analysis shows that the conventional viscometry strongly underestimates the rheological differences between normal and pathologically intensified aggregation. Based on detailed analysis under defined flow conditions in vitro, the biological significance of viscometric results and the hemodynamic relevance of red cell aggregates are discussed.
    Notes: Zusammenfassung Die scheinbare Viskosität des Blutes steigt bei langsamer Scherung in Rotationsviskosimetern durch die reversible Bildung von Erythrocytenaggregaten sehr stark an. Das Ausmaß des Viskositätsanstiegs hängt jedoch wesentlich von dem Hämatokritwert, daneben von der Plasmaviskosität und schließlich von den mikrorheologischen Eigenschaften der Aggregate ab. Die unabhängige Messung der mikrorheologischen Eigenschaften und des Viskositätsverhaltens erlaubt die detaillierte Analyse des hämodynamischen Effektes von Erythrocytenaggregaten unter definierten Fließbedingungen in vitro. Die vergleichende Analyse zeigt, daß die konventionelle Viskosimetrie die rheologischen Unterschiede zwischen normaler und pathologisch gesteigerter Aggregation eindeutig unterschätzt. Basierend auf der detaillierten Analyse unter definierten Bedingungen in vitro werden die biologische Bedeutung von viskometrischen Befunden und die hämodynamische Relevanz von Erythrocytenaggregaten abgehandelt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468880
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