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  • 1
    Electronic Resource
    Electronic Resource
    Red cell aggregation in blood flow (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 159-167 
    Details
    ISSN: 1432-1440
    Keywords: Blutrheologie ; Fahraeus-Effekt ; Rouleaux-Klumpen ; Rouleaux-Netzwerke ; scheinbare Blutviskosität ; scheinbare relative Blutviskosität ; Viscosimetrie ; Apparent blood viscosity ; blood rheology ; Fahraeus-effect ; relative apparent blood viscosity ; rouleaux clumps ; rouleaux networks ; viscometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The apparent viscosity of blood strongly increases at low shear in rotational viscometers, this phenomenon is based on the reversible formation of red cell aggregates. The magnitude of this increase strongly depends on the hematocrit value, on plasma viscosity and lastly on the microrheological properties of the aggregates. The independent measurement of the microrheological behavior and the effects on viscosity allows a detailed analysis of the hemodynamic effects of red cell aggregates under defined flow conditions in vivo. The comparative analysis shows that the conventional viscometry strongly underestimates the rheological differences between normal and pathologically intensified aggregation. Based on detailed analysis under defined flow conditions in vitro, the biological significance of viscometric results and the hemodynamic relevance of red cell aggregates are discussed.
    Notes: Zusammenfassung Die scheinbare Viskosität des Blutes steigt bei langsamer Scherung in Rotationsviskosimetern durch die reversible Bildung von Erythrocytenaggregaten sehr stark an. Das Ausmaß des Viskositätsanstiegs hängt jedoch wesentlich von dem Hämatokritwert, daneben von der Plasmaviskosität und schließlich von den mikrorheologischen Eigenschaften der Aggregate ab. Die unabhängige Messung der mikrorheologischen Eigenschaften und des Viskositätsverhaltens erlaubt die detaillierte Analyse des hämodynamischen Effektes von Erythrocytenaggregaten unter definierten Fließbedingungen in vitro. Die vergleichende Analyse zeigt, daß die konventionelle Viskosimetrie die rheologischen Unterschiede zwischen normaler und pathologisch gesteigerter Aggregation eindeutig unterschätzt. Basierend auf der detaillierten Analyse unter definierten Bedingungen in vitro werden die biologische Bedeutung von viskometrischen Befunden und die hämodynamische Relevanz von Erythrocytenaggregaten abgehandelt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468880
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  • 2
    Electronic Resource
    Electronic Resource
    Red cell aggregation in blood flow (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 149-157 
    Details
    ISSN: 1432-1440
    Keywords: Blutrheologie ; arterielle Verschlußkrankheiten ; Diabetes mellitus ; Myelom ; photometrische Aggregometrie ; Rouleaux-Bildung ; Rouleaux-Klumpen ; Rouleaux-Netzwerke ; scheinbare Blutviskosität ; Schwangerschaft ; Apparent blood viscosity ; arterial vascular disease ; blood rheology ; diabetes mellitus ; myeloma ; photometric aggregometry ; pregnancy ; rouleaux clumps ; rouleaux formation ; rouleaux networks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The rheological behavior of normal and pathological red cell aggregates in viscometric flow (artificial flow in cone plate chamber) is studied by direct microscopy, (rheoscopy) viscometry and photometry. Marked differences between normal and pathological blood are measured in the microrheological properties of red cell aggregates; only discreet differences are measured by blood viscometry (macrorheology). Both in normal and abnormal blood, red cell aggregation is a reversible process in the presence of adequate shear forces; their respective influences on apparent blood viscosity at low rates of shear are complex functions of shear rate, shear time, hematocrit and plasma viscosities. Pathological red cell aggregation (RCA) forms more rapidly and extensively than normal RCA. The pathological aggregates frequently have a tendency to grow at low rates of shear and they are highly shear resistant.
    Notes: Zusammenfassung Das rheologische Verhalten von normalen und pathologischen Erythrocytenaggregaten in viskometrischer Strömung (künstliche Strömung in Platte-Kegel-Kammer) wird mittels direkter mikroskopischer Beobachtung (im „Rheoskop“), Viskometrie und Photometrie untersucht. Erhebliche Unterschiede finden sich bei dem mikrorheologischen Verhalten, während im makrorheologischen Verhalten (Blut-Viskometrie) nur diskrete und oft komplexe Differenzen zwischen normalen und pathologischem Blut gemessen werden. Sowohl im normalen wie im pathologischen Blut ist die Erythrocytenaggregation ein reversibler Prozeß, vorausgesetzt, daß ausreichende Scherkräfte vorhanden sind. Der Einfluß der normalen und pathologischen Aggregate ist eine komplexe Funktion des Schergrades, der Scherzeit, des Hämatokritwertes und der Plasmaviskosität. Pathologische Erythrocytenaggregate bilden sich schneller und extensiver aus als normale Aggregate. Sie haben oft eine Tendenz, bei langsamer Strömung zu wachsen und sind hochgradig scherungsresistent:
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468879
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  • 3
    Electronic Resource
    Electronic Resource
    Die Struma Maligna (1922)
    Springer
    Journal of molecular medicine 1 (1922), S. 1687-1691 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Unter 655 von uns operierten Kröpfen befanden sich 20 maligne (17 Frauen, 3 Männer). Das 5. Lebensdezennium war am meisten bevorzugt. Die malignen Geschwülste (18 Carcinome, 2 Sarkome) entwickelten sich ausschließlich in dem rechten Lappen eines oft lange (einmal 26 Jahre!) bestehenden Knotenkropfes. Als auslösende Ursachen scheinen vor allem Traumen (Kröpfoperation), Einklemmung retrosternaler Strumen in Betracht zu kommen. Metastasen fanden sich 9 mal in der Lunge, 16 mal im Skelettsystem. Die Diagnose wurde gestellt: durch schnelleres Wachstum der Geschwulst, Konsistenzzunahme, verminderte Beweglichkeit, Schluckbeschwerden, Störungen der Atmung, Kreislaufstörungen, Nervenerscheinungen (ausstrahlende Kopf- und Armschmerzen), Heiserkeit, Basedowerscheinungen als Einleitungssymptom des bösartigen Wachstums sind für unsere Gegend charakteristisch. Eigentliche Krebskachexie wurde nicht beobachtet. So wichtig Laryngoskopie und Röntgenuntersuchung (Trachea, Lunge, Skelettsystem) für die Diagnostik sind, so gefährlich sind Probeexcision und -punktion. In zweifelhaften Fällen hat nach Vornahme möglichst weitgehender Kropfoperation die mikroskopische Untersuchung zu entscheiden. Die mittlere Dauer des Carcinoms der Schilddrüse wurde auf 2 Jahre errechnet (7 Wochen bis 3 Jahre). Bei Frühdiagnose eines noch begrenzten bösartigen Schilddrüsentumors ist die Totalexstirpation mit nachfolgender Röntgenbestrahlung die Methode der Wahl, bei fortgeschrittenem, infiltrierendem Wachstum ist der Strahlen behandlung allein, in exakter Dosierung (FelderwählerHolfelders), der Vorzug zu geben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01734609
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  • 4
    Electronic Resource
    Electronic Resource
    Über Kropfrezidive (1922)
    Springer
    Journal of molecular medicine 1 (1922), S. 1885-1889 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713956
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  • 5
    Electronic Resource
    Electronic Resource
    Ludwig Rehn (1930)
    Springer
    Journal of molecular medicine 9 (1930), S. 1335-1335 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01739466
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  • 6
    Electronic Resource
    Electronic Resource
    Digital radiography Results of a survey (part A) and a consensus conference (part B) (1997)
    Springer
    European radiology 7 (1997), S. S94 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Digital radiography ; Storage phosphor radiography ; Digital image intensifier radiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Digital imaging (digital image intensifier radiography, storage phosphor/selenium radiography) is increasingly becoming commonplace in radiology departments for diagnostic purposes. Despite 10 years of experience, the advantages and disadvantages of those methods are still heavily discussed among users, financiers and prescribers. This paper is to offer additional arguments for a thorough and objective discussion. No further comments or interpretations have been added to this paper. This paper consists of two main parts, A and B. The first part deals with the results of a user survey, the other part presents the results, i. e. statements, of a consensus conference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006872
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  • 7
    Electronic Resource
    Electronic Resource
    Peripheral circulation in the newborn: Interaction of peripheral blood flow, blood pressure, blood volume, and blood viscosity (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 73-81 
    Details
    ISSN: 1432-1076
    Keywords: Blood pressure ; Blood viscosity ; Blood volume ; Newborn infants ; Peripheral blood flow ; Peripheral resistance ; Premature infants ; Respiratory distress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral blood flow and systolic blood pressure (strain-gauge plethysmograph), blood volume (Evans blue) and whole blood viscosity (cone-plate viscometer) have been measured in 66 premature and full-term infants 6 to 144h of age. Blood flow and blood volume were moderately decreased in the infants with respiratory distress. Highly significant (P〈0.001) correlations were found betwen blood flow and blood volume (r=0.77), blood pressure and blood volume (r=0.50), peripheral resistance and blood volume (r=-0.44), blood flow and blood pressure (r=0.50), blood flow and peripheral resistance (r=-0.67), peripheral resistance and blood viscosity (r=0.45), and blood viscosity and haematocrit (r=0.86). There was no correlation between peripheral blood flow and blood viscosity. However, at given blood volume, peripheral blood flow decreased with increasing blood viscosity. These results indicate that in newborn infants peripheral blood flow, blood pressure and peripheral resistance are influenced by blood volume, but also depend on blood viscosity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442366
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  • 8
    Electronic Resource
    Electronic Resource
    Solitary hepatic hemangioma in a newborn infant complicated by cardiac failure, consumption coagulopathy, microangiopathic hemolytic anemia, and obstructive jaundice (1976)
    Springer
    European journal of pediatrics 124 (1976), S. 23-29 
    Details
    ISSN: 1432-1076
    Keywords: Newborn ; Hepatic hemangioma ; Cardiac failure ; Consumption coagulopathy ; Microangiopathic hemolytic anemia ; Blood volume
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A newborn infant with a large hepatic hemangioma developed congestive heart failure, consumption coagulopathy, microangiopathic hemolytic anemia, and obstructive jaundice. The patient was mildly heparinized (250 units per kg and day) and underwent successful resection of the tumor without lobectomy at the age of 3 days. Blood volume increased from 93.9 ml/kg at the age of 5 h to 124.2 ml/kg prior to surgery. Red-cell mass simultaneously decreased from 53.8 to 39.4 ml/kg. The increase of blood volume is explained by congestive heart failure, the decrease of red-cell mass by intravascular coagulation within the tumor resulting in formation of thrombi and microangiopathic hemolytic anemia. A review of the literature on infants with symptoms caused by an intrahepatic hemangioma during the first month of life confirms that surgical intervention is the treatment of choice for infants with giant solitary hemangioma of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00452410
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  • 9
    Electronic Resource
    Electronic Resource
    Deutung des Zusammenhanges zwischen elastischen Fasern, Gefäßen und Psammomkörperbildung in Meningiomen (1961)
    Springer
    Acta neurochirurgica 9 (1961), S. 359-366 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Meningiomata were investigated as to presence and localisation of elastic fibres. They occur only in the vessels and their adventitia and are not found free in the tumour tissue. Regarding psammoma body formation from vessels, there is initially proliferation in the course of which the elastic fibres are enlarged and ultimately occupy the whole lumen of the vessel through displacement of the endothelium. In this state the occluded vessels appear under the microscope as homogenous elastic areas. The deposition of calcium can follow, it begins mainly in the periphery and progresses centrally. One occasionally sees a central calcification.
    Abstract: Résumé Les méningiomes furent étudiés au point de vue de la présence et de la localisation des fibres élastiques. Elles apparaissent seulement dans les vaisseaux et leur adventice et non dans le tissu tumoral. Pour ce qui est de la formation des corps psammiques à partir des vaisseaux il y a d'abord prolifération et élargissement des fibres élastiques. Ultérieurement elles occupent toute la lumière du vaisseau par un déplacement de l'endothélium et les vaisseaux obturés apparaissent sous le microscope comme des aires élastiques homogènes. Le dépôt de calcaire peut suivre, il commence surtout à la périphérie et progresse vers le centre. Il y a parfois une calcification centrale.
    Notes: Zusammenfassung Meningiome wurden auf das Vorkommen und die Lokalisation von elastischen Fasern untersucht. Sie finden sich nur in den Gefäßen und ihrer Adventitia, nicht frei in Tumorgewebe. Bei der Psammomkörperbildung aus Gefäßen kommt es zunächst zur Lumeneinengung und zum Verschluß durch Endothelproliferation, wobei die elastischen Fasern sich vergrößern und schließlich unter Verdrängung des gewucherten Endothels das ganze Gefäßlumen einnehmen und als homogene elastische Platten im mikroskopischen Bild sichtbar sind. Die Kalkeinlagerung kann sich anschließen, die häufig in der Peripherie beginnt und nach innen fortschreitet. Seltener beobachtet man eine zentrale Verkalkung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809162
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  • 10
    Electronic Resource
    Electronic Resource
    Detection of all anti-factor VIII antibodies in haemophilia A patients by the Bethesda assay and a more sensitive immunoprecipitation assay (2001)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 7 (2001), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Plasmas from 40 haemophilia A patients enrolled in a study by the paediatric group of the German Society on Thrombosis and Hemostasis were tested by the Bethesda assay for inhibitor antibodies and by a more sensitive immunoprecipitation assay (IP) for all antifactor VIII antibodies. Of the 26 severe, 11 moderate and three mild haemophiliacs, 18, two, and none, respectively, had positive Bethesda titres after several factor VIII infusions. In 275 plasmas with Bethesda titres of 0, 0.6–1.0, 〉 1–5, and 〉 5–655, the IP responses were 0–238, 0–61, 0–786, and 43–6141, respectively, and a reliable positive IP titre was 〉 4.2. The overlapping ranges of IP titres indicated large differences in the ratio of inhibitory to noninhibitory antibodies in individual plasmas. In five of seven patients with Bethesda titres of 0.6–1, the IP titres were 〈 4.2, suggesting a lack of precision of Bethesda titres ≤ 1. Detection of the primary immune response was found in only three patients by IP assay before a positive Bethesda assay. This precludes early, reliable testing of which patients will be immunologically responsive. In four patients undergoing immune tolerance therapy, antifactor VIII antibodies were still detectable by the IP assay in the absence of a Bethesda titre, which indicates that antibodies were completely eradicated in none of the patients. Our results show that the use of both the Bethesda and IP assays can provide more accurate detection of antifactor VIII antibodies in all patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2001.00456.x
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