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  • 1
    Electronic Resource
    Electronic Resource
    Stress at birth: Plasma noradrenaline concentrations of women in labour and in cord blood (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 311-312 
    Details
    ISSN: 1432-1440
    Keywords: Plasma-Noradrenalin ; Nabelschnurblut ; mütterliches Blut ; Geburt ; akute und chronische Beeinträchtigung ; Plasma noradrenaline ; cord blood ; maternal blood ; delivery ; acute and chronic fetal distress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Radioenzymatically measured plasma noradrenaline concentrations, present at birth in umbilical veins of 19 healthy, 17 acutely asphyxiated, and 9 chronically distressed newborn infants were found to be elevated above maternal values proportional to the degree of distress and to plasma H ion concentrations.
    Notes: Zusammenfassung Die radioenzymatisch bestimmten Plasma-Noradrenalin-Konzentrationen des Nabelvenenblutes, entnommen bei der Geburt von 19 normalvitalen, 17 akut asphyxierten und 9 chronisch hypoxie-gefährdeten Neugeborenen waren stets größer als die zugehörigen mütterlichen Werte. Es ergab sich eine signifikante Abhängigkeit vom Ausmaß der Beeinträchtigung und eine positive Korrelation mit der Wasserstoffionen-Konzentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01489179
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 98-100 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01467767
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  • 3
    Electronic Resource
    Electronic Resource
    Thyroxine and red cell 2,3-diphosphoglycerate in the newborn period (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 138-139 
    Details
    ISSN: 1432-1440
    Keywords: Newborns ; thyroxine ; 2,3-diphosphoglycerate ; acid-base balance ; hemoglobin-O2-affinity ; Neugeborene ; Thyroxin ; 2,3-Diphosphoglycerat ; Säure-Base-Gleichgewicht ; Hämoglobin-O2-Affinität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 12 gesunden Neugeborenen wurden die 2,3-Diphosphoglycerat-Konzentration im Erythrocyten und die Thyroxinkonzentration im Plasma während der ersten 2 Lebenswochen bestimmt. Aus den erhobenen Befunden wird geschlossen, daß Thyroxin die 2,3-Diphosphoglyceratsynthese steigert. Damit leitet Thyroxin, über das 2,3-Diphosphoglycerat, die postnatal beschleunigt einsetzende Abnahme der Hämoglobin-O2-Affinität ein, womit eine erleichterte O2-Abgabe an die Gewebe verbunden ist.
    Notes: Summary In 12 healthy newborn infants, red cell 2,3-diphosphoglycerate and plasma thyroxine levels were studied during the first 2 weeks of life. The data obtained indicate that thyroxine increases the 2,3-diphosphoglycerate concentration in the erythrocytes. Thus, thyroxine initiates via 2,3-diphosphoglycerate the accelerated decline of hemoglobin oxygen affinity taking place after birth, which facilates oxygen release from hemoglobin to the tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483922
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of 2,3-diphosphoglycerate on the rate of oxidation of hemoglobin to methemoglobin (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 93-94 
    Details
    ISSN: 1432-1440
    Keywords: 2,3-diphosphoglycerate ; potassium ferricyanide ; adult hemoglobin ; cord blood hemoglobin ; oxidation rate ; methemoglobin ; 2,3-Diphosphoglycerat ; Kaliumferricyanid ; Erwachsenenhämoglobin ; Nabelschnurhämoglobin ; Oxydationsgeschwindigkeit ; Methämoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 2,3-Diphosphoglycerat, das die Desoxykonfiguration des Hämoglobins begünstigt, beschleunigt die Oxydation des Hämoglobins zu Methämoglobin durch Kaliumferricyanid in Hämolysaten aus Erwachsenen- und Nabelschnurblut. Die Hämoglobinoxydation wird in Nabelschnurhämolysaten weniger beschleunigt.
    Notes: Summary 2,3-diphosphoglycerate, favoring the deoxyconfiguration of the hemoglobin molecule, accelerates the oxidation of hemoglobin to methemoglobin by potassiumferricyanide both in hemolysates from adult and cord blood. Hemoglobin oxidation is less enhanced in cord blood hemolysates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01467764
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  • 5
    Electronic Resource
    Electronic Resource
    Studien zur Blutmorphologie des Neugeborenen (1954)
    Springer
    Journal of molecular medicine 32 (1954), S. 741-742 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Blutuntersuchung an 10 gesunden, reifen Neugeborenen ergibt für jedes einzelne Kind, daß sich die Erythrocytenfläche nach Einsetzen der Lungenatmung bei unverändertem Erythrocyten-Einzelvolumen signifikant vergrößert. Der Zeitpunkt der größten Flächenzunahme fällt nicht mit dem Anstieg der Erythrocytenzahlen zusammen. Es handelt sich um eine Vergrößerung der im Blute des Neugeborenen befindlichen Erythrocyten, die während der ganzen Neugeborenenzeit unverändert groß bleiben. Eine solche Flächenvergrößerung der Nabelschnurerythrocyten läßt sich nach Sauerstoffzufuhr auch in vitro nachweisen; sie tritt sogar unter dem Einfluß der Ausatmungsluft ein und ist in vitro reversibel. Diese Fähigkeit zur Oberflächenvergrößerung scheint in Zusammenhang zu stehen mit dem Gehalt an fetalem Hämoglobin und dem post partum durch die Lungenatmung veränderten Sauerstoffangebot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01481163
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of intra-partum and intra-uterine asphyxia on placental transfusion in premature and full-term infants (1978)
    Springer
    European journal of pediatrics 127 (1978), S. 91-99 
    Details
    ISSN: 1432-1076
    Keywords: Newborn infants ; Premature infants ; Asphyxia ; Caesarean section ; Nuchal cord ; Blood volume ; Red cell mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood volume and its components were estimated using 125iodinated human serum albumin in 194 newborn infants with 26 to 41 week gestations. Umbilical cords were ligated 15 seconds after vaginal delivery (n=141) and within 5 seconds after delivery by Caesarean section (n=53). The infants were divided into four groups according to the mode of delivery and presence of prenatal complications: group I: vaginal deliveries (n=96) and group II: Caesarean section (n=25) without preceding complications; group III: infants with intra-uterine asphyxia (n=56); group IV: infants with tight umbilical cord loops around neck (n=17). Subgroups were established with respect to gestational age and to one-minute Apgar scores. Significantly different blood volume (BV) and red cell mass (RCM) values between the subgroups were only found in group I with respect to different Apgar scores: Ia Apgar〉5: BV 77.9±6.2; RCM 37.5±5.1 ml/kg; Ib Apgar〈6: BV 70.0±4.4; RCM 29.6±2.9 ml/kg (P〈0.005). Intra-partum asphyxia did not affect BV (71.3±4.8 ml/kg) and RCM (31.2±3.6 ml/kg) in group II. BV and RCM were significantly (P〈0.005) lower than in group Ia. In group III, BV (90.4±7.0 ml/kg) and RCM (46.9±6.3 ml/kg) were significantly (P〈0.005) higher than in group I, irrespective of the mode of delivery and Apgar scores. The infants of group IV had the lowest volumes (BV 67.5±5.7; RCM 27.4±2.7 ml/kg). Values obtained in premature and full-term infants were similar in the respective groups. These results indicate that infants with intra-partum asphyxia and with tight nuchal cords do not participate in placental transfusion or even lose some blood into the placenta. However, infants with intrauterine asphyxia (excepting those with tight nuchal cords) receive marked placental transfusion in utero.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445764
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  • 7
    Electronic Resource
    Electronic Resource
    Plasma volume estimation in severely ill infants and children using a simplified Evans blue method (1977)
    Springer
    European journal of pediatrics 125 (1977), S. 135-141 
    Details
    ISSN: 1432-1076
    Keywords: Evans blue ; 125Iodinated albumin ; Plasma volume ; Capillary permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma volume was measured using Evans blue dye and 125iodinated human serum albumin (RIHSA) simultaneously in order to evaluate the accuracy of a simplified Evans blue method recommended by Nielsen and Nielsen (1962). 9 studies were performed in 8 newborn infants weighing 1.07 to 2.85 kg and 16 studies in 14 patients aged 6 months to 14 years suffering from severe circulatory disturbances. In 20 studies, plasma volumes measured by Evans blue and by RIHSA agreed within ±5%, and in all the studies within ±10%. The Evans blue method yielded higher plasma volumes than the RIHSA method in 19 instances. The mean difference (paired t-test) was only significant in newborn infants (+4.0±3.6%; P〈0.05). The disappearance rates of Evans blue exceeded that of RIHSA in 16 studies, but this was only significant in the patients older than 6 months (+2.3±4.2%/h; P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00489986
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  • 8
    Electronic Resource
    Electronic Resource
    Accuracy of blood volume estimations in critically I11 children using 125I-labelled albumin and 51Cr-labelled red cells (1977)
    Springer
    European journal of pediatrics 125 (1977), S. 143-151 
    Details
    ISSN: 1432-1076
    Keywords: Blood volume ; Plasma volume ; Red cell mass ; Body/venous haematocrit ratio ; Segregation of red cells ; Capillary permeability ; Sepsis ; Leukaemia ; Burns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood volume was estimated using 51chromium labelled red cells and 125iodinated human serum albumin in 5 children with sepsis, in 6 burned children and 7 children with acute lymphoblastic leukaemia. Studies of the equilibration pattern demonstrated that the mixing time of labelled red cells was prolonged to 40 minutes or more in 5 children, indicating the existence of slowly circulating red cells. Mixing of labelled albumin was complete within 10 minutes in 15 patients and within 20 minutes in all the children studied. In a burned patient with severe sepsis, exchange transfusion improved the clinical state and normalized the equilibration pattern of labelled red cells. The mean body/venous haematocrit ratio was 0.893±0.018 (SD) in the children with sepsis, 0.859±0.052 in the burned patients, and 0.916±0.078 in the children with acute lymphoblastic leukaemia, increasing with spleen size in the latter group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00489987
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  • 9
    Electronic Resource
    Electronic Resource
    Capillary-venous hematocrit differences in newborn infants (1977)
    Springer
    European journal of pediatrics 127 (1977), S. 9-14 
    Details
    ISSN: 1432-1076
    Keywords: Newborn infants ; Blood pressure ; Hematocrit ; Blood volume ; Acid-base status ; Red cell mass ; Peripheral blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Venous and capillary hematocrit, acid base values, and circulatory parameters were measured simultaneously in 92 newborn infants within six hours of birth. Gestational age ranged from 26 to 41 weeks. The capillary/ venous hematocrit ratio (Hctc/Hctv) was greater than 1.00 in 89 infants. We found significant inverse correlations between Hctc/Hctv and several parameters, such as pH (r=-0.82), standard bicarbonate (r=-0.73), systolic blood pressure (r=-0.51), and peripheral blood flow (r=-0.70). Most of the infants with a Hctc/Hctv of 1.20 and above had red cell mass values of less than 35 ml/kg. However, blood volume apparently did not influence the Hctc/Hctv. Gestational age appeared to affect Hctc/Hctv only before 30 weeks, when compared with the Hctc/Hctv of term infants. Our results indicate that disturbed circulation, and in particular, disturbed microcirculation, is involved in the development of high Hctc/Hctv ratios. We strongly advise that hematocrits obtained by skin prick from a sick newborn infant should not be relied on as they may give misleading information on oxygen carrying capacity to vital organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465560
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  • 10
    Electronic Resource
    Electronic Resource
    Peripheral circulation in the newborn: Interaction of peripheral blood flow, blood pressure, blood volume, and blood viscosity (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 73-81 
    Details
    ISSN: 1432-1076
    Keywords: Blood pressure ; Blood viscosity ; Blood volume ; Newborn infants ; Peripheral blood flow ; Peripheral resistance ; Premature infants ; Respiratory distress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral blood flow and systolic blood pressure (strain-gauge plethysmograph), blood volume (Evans blue) and whole blood viscosity (cone-plate viscometer) have been measured in 66 premature and full-term infants 6 to 144h of age. Blood flow and blood volume were moderately decreased in the infants with respiratory distress. Highly significant (P〈0.001) correlations were found betwen blood flow and blood volume (r=0.77), blood pressure and blood volume (r=0.50), peripheral resistance and blood volume (r=-0.44), blood flow and blood pressure (r=0.50), blood flow and peripheral resistance (r=-0.67), peripheral resistance and blood viscosity (r=0.45), and blood viscosity and haematocrit (r=0.86). There was no correlation between peripheral blood flow and blood viscosity. However, at given blood volume, peripheral blood flow decreased with increasing blood viscosity. These results indicate that in newborn infants peripheral blood flow, blood pressure and peripheral resistance are influenced by blood volume, but also depend on blood viscosity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442366
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