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  • 1
    Electronic Resource
    Electronic Resource
    Fluidlike ordered colloidal suspensions: the influence of electrolytes on the structure factor S(Q) (1992)
    s.l. : American Chemical Society
    Langmuir 8 (1992), S. 2885-2888 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00048a008
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 1356-1356 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720557
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  • 3
    Electronic Resource
    Electronic Resource
    Thyroxine and red cell 2,3-diphosphoglycerate in the newborn period (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 138-139 
    Details
    ISSN: 1432-1440
    Keywords: Newborns ; thyroxine ; 2,3-diphosphoglycerate ; acid-base balance ; hemoglobin-O2-affinity ; Neugeborene ; Thyroxin ; 2,3-Diphosphoglycerat ; Säure-Base-Gleichgewicht ; Hämoglobin-O2-Affinität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 12 gesunden Neugeborenen wurden die 2,3-Diphosphoglycerat-Konzentration im Erythrocyten und die Thyroxinkonzentration im Plasma während der ersten 2 Lebenswochen bestimmt. Aus den erhobenen Befunden wird geschlossen, daß Thyroxin die 2,3-Diphosphoglyceratsynthese steigert. Damit leitet Thyroxin, über das 2,3-Diphosphoglycerat, die postnatal beschleunigt einsetzende Abnahme der Hämoglobin-O2-Affinität ein, womit eine erleichterte O2-Abgabe an die Gewebe verbunden ist.
    Notes: Summary In 12 healthy newborn infants, red cell 2,3-diphosphoglycerate and plasma thyroxine levels were studied during the first 2 weeks of life. The data obtained indicate that thyroxine increases the 2,3-diphosphoglycerate concentration in the erythrocytes. Thus, thyroxine initiates via 2,3-diphosphoglycerate the accelerated decline of hemoglobin oxygen affinity taking place after birth, which facilates oxygen release from hemoglobin to the tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483922
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 466-466 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695902
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of 2,3-diphosphoglycerate on the rate of oxidation of hemoglobin to methemoglobin (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 93-94 
    Details
    ISSN: 1432-1440
    Keywords: 2,3-diphosphoglycerate ; potassium ferricyanide ; adult hemoglobin ; cord blood hemoglobin ; oxidation rate ; methemoglobin ; 2,3-Diphosphoglycerat ; Kaliumferricyanid ; Erwachsenenhämoglobin ; Nabelschnurhämoglobin ; Oxydationsgeschwindigkeit ; Methämoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 2,3-Diphosphoglycerat, das die Desoxykonfiguration des Hämoglobins begünstigt, beschleunigt die Oxydation des Hämoglobins zu Methämoglobin durch Kaliumferricyanid in Hämolysaten aus Erwachsenen- und Nabelschnurblut. Die Hämoglobinoxydation wird in Nabelschnurhämolysaten weniger beschleunigt.
    Notes: Summary 2,3-diphosphoglycerate, favoring the deoxyconfiguration of the hemoglobin molecule, accelerates the oxidation of hemoglobin to methemoglobin by potassiumferricyanide both in hemolysates from adult and cord blood. Hemoglobin oxidation is less enhanced in cord blood hemolysates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01467764
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of intra-partum and intra-uterine asphyxia on placental transfusion in premature and full-term infants (1978)
    Springer
    European journal of pediatrics 127 (1978), S. 91-99 
    Details
    ISSN: 1432-1076
    Keywords: Newborn infants ; Premature infants ; Asphyxia ; Caesarean section ; Nuchal cord ; Blood volume ; Red cell mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood volume and its components were estimated using 125iodinated human serum albumin in 194 newborn infants with 26 to 41 week gestations. Umbilical cords were ligated 15 seconds after vaginal delivery (n=141) and within 5 seconds after delivery by Caesarean section (n=53). The infants were divided into four groups according to the mode of delivery and presence of prenatal complications: group I: vaginal deliveries (n=96) and group II: Caesarean section (n=25) without preceding complications; group III: infants with intra-uterine asphyxia (n=56); group IV: infants with tight umbilical cord loops around neck (n=17). Subgroups were established with respect to gestational age and to one-minute Apgar scores. Significantly different blood volume (BV) and red cell mass (RCM) values between the subgroups were only found in group I with respect to different Apgar scores: Ia Apgar〉5: BV 77.9±6.2; RCM 37.5±5.1 ml/kg; Ib Apgar〈6: BV 70.0±4.4; RCM 29.6±2.9 ml/kg (P〈0.005). Intra-partum asphyxia did not affect BV (71.3±4.8 ml/kg) and RCM (31.2±3.6 ml/kg) in group II. BV and RCM were significantly (P〈0.005) lower than in group Ia. In group III, BV (90.4±7.0 ml/kg) and RCM (46.9±6.3 ml/kg) were significantly (P〈0.005) higher than in group I, irrespective of the mode of delivery and Apgar scores. The infants of group IV had the lowest volumes (BV 67.5±5.7; RCM 27.4±2.7 ml/kg). Values obtained in premature and full-term infants were similar in the respective groups. These results indicate that infants with intra-partum asphyxia and with tight nuchal cords do not participate in placental transfusion or even lose some blood into the placenta. However, infants with intrauterine asphyxia (excepting those with tight nuchal cords) receive marked placental transfusion in utero.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445764
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  • 7
    Electronic Resource
    Electronic Resource
    Randomized controlled trial of Ringer solution versus serum for partial exchange transfusion in neonatal polycythaemia (1994)
    Springer
    European journal of pediatrics 154 (1994), S. 53-56 
    Details
    ISSN: 1432-1076
    Keywords: Key words     Polycythaemia ; Neonate ; Exchange transfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      We tested whether crystalliod solutions could be used instead of colloid solutions for partial exchange transfusions (PET) in polycythaemic neonates because crystalloid solutions are cheap, carry no risk of anaphylactic reactions and can be sterilized. We randomly assigned 20 term neonates with venous haematocrit (Hct) 〉 0.65 l/l to PET with either a serum preparation (BISEKO) or Ringer solution. Plasma volume (PV) was measured with Evans blue dilution. Blood volume (BV) and red cell mass were calculated from PV and venous Hct. Before PET both serum and Ringer groups had the same Hct (0.69 (0.66–0.76) vs 0.69 (0.66–0.71) l/l; median (range)) and BV (108 (81–116) versus 96 (68–121) ml/kg. During PET an equivalent amount of blood was withdrawn stepwise (19 (14–26) versus 17 (13–25) ml/kg and replaced by either serum or Ringer solution. More of the Ringer solution (median 77%) than of the serum (median 36%) given left the intravascular space within 4 h after PET (P = 0.016); but there was no signficant difference in Hct after Ringer-PET compared to serum-PET (median 0.58 vs 0.56 l/l). No infant required repeat PET. Ringer-PET reduced BV from high to normal values (from median 96 to 83 ml/kg; P = 0.005), whereas after serum-PET BV remained high (from median 108 to 98 ml/kg; not significant). Conclusion     PET with Ringer solution resulted in a haemodilution comparable to PET with serum and a correction of hypervolaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972973
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  • 8
    Electronic Resource
    Electronic Resource
    HbM Erlangen: α2β2 63 (E7) Tyr (1975)
    Springer
    European journal of pediatrics 120 (1975), S. 69-78 
    Details
    ISSN: 1432-1076
    Keywords: Hemoglobin M Erlangen ; Hemolysis ; NADH-methemoglobin reductase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bericht über die Beobachtung einer neuen HbM-Variante bei einem 4jährigen Jungen mit kongenitaler Cyanose. Die Strukturaufklärung ergab Identität mit HbM Saskatoon = β63 His → Tyr. Bei keinem der untersuchten Familienangehörigen war eine Blutfarbstoffanomalie vorhanden, so daß es sich um eine neue Mutation handelt. HbM Erlangen weist eine normale Sauerstofftransportfunktion auf. Es ist kombiniert mit einer kompensierten Hämolyse, die wahrscheinlich durch eine erhöhte Instabilität des abnorm strukturierten Hämoglobins verursacht wird. Gleichzeitig fand sich eine verminderte Aktivität der NADH-Methämoglobinreduktase.
    Notes: Abstract Report on a further hemoglobin M variant, discovered in a boy with congenital cyanosis. Chemical analysis of hemoglobin structure revealed indentity with HbM Saskatoon (= β63 His → Tyr). The abnormal hemoglobin is characterized by normal oxygen transport function. The observed slight constant hemolysis is thought to be due to increased instability of the abnormal hemoglobin molecule. In addition to the hemoglobin anomaly, the activity of NADH-methemoglobin reductase was reduced by approximately 40% of normal. None of the parents presented with an abnormal hemoglobin, indicating that the occurrence of hemoglobin M Erlangen is most likely the result of a new mutation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443801
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  • 9
    Electronic Resource
    Electronic Resource
    Capillary-venous hematocrit differences in newborn infants (1977)
    Springer
    European journal of pediatrics 127 (1977), S. 9-14 
    Details
    ISSN: 1432-1076
    Keywords: Newborn infants ; Blood pressure ; Hematocrit ; Blood volume ; Acid-base status ; Red cell mass ; Peripheral blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Venous and capillary hematocrit, acid base values, and circulatory parameters were measured simultaneously in 92 newborn infants within six hours of birth. Gestational age ranged from 26 to 41 weeks. The capillary/ venous hematocrit ratio (Hctc/Hctv) was greater than 1.00 in 89 infants. We found significant inverse correlations between Hctc/Hctv and several parameters, such as pH (r=-0.82), standard bicarbonate (r=-0.73), systolic blood pressure (r=-0.51), and peripheral blood flow (r=-0.70). Most of the infants with a Hctc/Hctv of 1.20 and above had red cell mass values of less than 35 ml/kg. However, blood volume apparently did not influence the Hctc/Hctv. Gestational age appeared to affect Hctc/Hctv only before 30 weeks, when compared with the Hctc/Hctv of term infants. Our results indicate that disturbed circulation, and in particular, disturbed microcirculation, is involved in the development of high Hctc/Hctv ratios. We strongly advise that hematocrits obtained by skin prick from a sick newborn infant should not be relied on as they may give misleading information on oxygen carrying capacity to vital organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465560
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  • 10
    Electronic Resource
    Electronic Resource
    Die infantile myoklonische Encephalopathie (1971)
    Springer
    European journal of pediatrics 111 (1971), S. 67-82 
    Details
    ISSN: 1432-1076
    Keywords: Myoclonic Encephalopathy ; Opsoclonus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Berichten über 17 Fälle von infantiler myoklonischer Encephalopathie in der Literatur wird über 4 weitere Patienten mit dieser Erkrankung berichtet. Es handelt sich um eine Erkrankung des späten Säuglings- und Kleinkindesalters, die akut beginnt und die durch Myokloni der gesamten Willkürmuskulatur, durch heftige, sakkadierte Augenbewegungen (Opsoklonus) und durch gesteigerte Irritabilität gekennzeichnet ist. EEG und Liquor cerebrospinalis sind nicht pathologisch verändert. Pathologisch-anatomisch liegen die Veränderungen in den Purkinjezellen und im Nucleus dentatus des Kleinhirns sowie in der weißen Substanz des Großhirns. Eine Behandlung mit Corticoiden oder ACTH kann die Symptome der Erkrankung rasch beheben, muß jedoch meist über Monate oder Jahre durchgeführt werden und scheint häufige Spätschäden auf motorischem, intellektuellem und sprachlichem Gebiet nicht verhindern zu können. Unbehandelt verläuft die Erkrankung über lange Zeit mit Remissionen und meist infektbedingten Exacerbationen. Es werden die ätiologischen Möglichkeiten (von denen eine immunologische Reaktion auf verschiedenartige Antigene am wahrscheinlichsten ist) sowie die Tatsache diskutiert, daß ein identisches Krankheitsbild in Verbindung mit einem Neuroblastom vorkommen kann.
    Notes: Abstract Four cases of infantile myoclonic encephalopathy Kinsbourne are described and discussed in relation to the 17 cases reported so far in the literature. The disease exclusively affects infants between 6 months and 2 years. It is characterized by diffuse myoclonic jerks in all striated muscles, by vigorous fast and mostly conjugated movements in all directions of the bulbi (opsoclonus), and by increased irritability. EEG and CSF are normal. Pathological changes are found in the Purkinje-cells, the nucleus dentatus of the cerebellum, and the white matter of the cerebrum. The disease is protracted over months or years, with remissions and exacerbations, but non-progressive and ultimately self-limiting. Treatment with corticosteroids or corticotropin leads to rapid disappearance of the neurological symptoms, but apparently can not prevent the frequent sequelae for intellectual, speach and motor development. It is suggested that the disease is caused by an immunological reaction to various agents. Furthermore, there is a discussion of the implications of the fact that an identical syndrome is encountered in young patients with neuroblastoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00438444
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