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  • 1
    Electronic Resource
    Electronic Resource
    DEFINED IMMUNOFLUORESCENCE STUDIES OF ANTICOLLAGEN SERA (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 254 (1975), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1975.tb29208.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    UVA- and UVB-induced changes in hairless mouse skin collagen (1994)
    Springer
    Archives of dermatological research 286 (1994), S. 490-494 
    Details
    ISSN: 1432-069X
    Keywords: Skin collagen ; UV effects ; Hairless mice ; Collagen solubility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract UVA- and UVB-induced alterations in dermal collagen were investigated in a murine animal model. Groups of hairless mice were exposed to UVA and UVB for 28 weeks at a dose of 60 J/cm2 three times weekly and 0.06 J/cm2 three times weekly, respectively. Untreated animals were used as controls. Every 4 weeks dorsal skin was examined for quantitative and qualitative changes in dermal collagen. Neither UVA nor UVB caused a significant alteration in total skin collagen content. However, after UVA treatment the ability of skin collagen to be digested by pepsin decreased dramatically (up to 65% of skin collagen remained insoluble after 4 months), whereas exposure to UVB had no significant effect. Furthermore a shift in the ratio of α1(I,III) chains to α2(I) chains was detected after UVA exposure. The amount of type V collagen in mouse skin, as determined by a sensitive ELISA method, was markedly decreased after UVA treatment, but not after UVB treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371578
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experimental treatment of chronic lymphocytic leukemia with extracorporeal photochemotherapy (1990)
    Springer
    Annals of hematology 60 (1990), S. 215-218 
    Details
    ISSN: 1432-0584
    Keywords: Photopheresis ; Extracorporeal photochemotherapy ; Chronic lymphocytic leukemia ; 8-Methoxypsoralen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Based on the encouraging results obtained with extracorporeal photochemotherapy (EP) in the treatment of the exfoliative erythrodermic form of cutaneous T-cell lymphoma (CTCL), leukemic form, as well as other T-cell-mediated diseases we evaluated the therapeutic potential of EP in patients with chronic lymphocytic leukemia (B-CLL). Three patients with B-CLL were treated for a period of 1 year. Two patients showed stabilization of disease, as demonstrated by reduction in their peripheral white blood cell count, with one patient showing lymph-node resolution. A third patient with significant intolerance to previous chemotherapy did not respond within the observed period. No significant side effects of EP were observed. Our observations suggest that EP may have a positive effect on the course of B-CLL in selected patients. Additional clinical trials are warranted to further define the role of EP alone or in combination therapy in the management of B-CLL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728786
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  • 4
    Electronic Resource
    Electronic Resource
    Antibody formation against human collagen and C1q in response to a bovine collagen implant (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 395-399 
    Details
    ISSN: 1432-069X
    Keywords: Bovine collagen implant ; Immune response ; Autoantibodies ; Human collagen ; C1q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The humoral immune response to commercially available bovine collagen implants (Zyderm, Zyplast) is characterized in a 45-year-old female patient. Circulating anti-collagen antibodies were detected after eight injections of Zyderm and after two injections of Zyplast given during a period of 3 years. The specificity of these antibodies for bovine and human collagens as well as for the collagen-like region of C1q (a subcomponent of the first component of complement), was investigated by affinity chromatography. Serum levels of anti-collagen and anti-C1q antibodies were measured using ELISA. High levels of antibodies to bovine collagens, showing a strong cross-reactivity with human collagen type III were detected in the patient's serum. Only weak cross-reactivity with human collagen type I and IV and no reactivity with type II were observed. In addition, these antibodies specifically cross-reacted with the collagen-like region of C1q. The antibody levels decreased continuously and disappeared 1 year after cessation of treatment. These results demonstrate for the first time the formation of autoantibodies upon treatment with a bovine collagen implant. Although antibodies to collagens and C1q have been found in various autoimmune diseases, neither adverse reactions to the bovine collagen implant nor any other clinical symptoms were observed in association with the described antibody response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371822
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  • 5
    Electronic Resource
    Electronic Resource
    78. Die Mehrschritt-Therapie des Melanomalignoms (1976)
    Springer
    Langenbeck's archives of surgery 342 (1976), S. 549-551 
    Details
    ISSN: 1435-2451
    Keywords: Melanoma ; Treatment, multiple-stage ; Melanom ; Mehrschrittstherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über 11 weit fortgeschrittene Melanompatienten berichtet, die in einer modifizierten Form der Krebs-Mehrschrittstherapie behandelt wurden. Das Ergebnis konnte den Verlauf nicht bessern, möglicherweise eine geringgradige Lebensverlängerung bringen.
    Notes: Summary The paper reports on 11 patients with very advanced melanoma, who were treated with a modified version of multiple-stage cancer therapy. No improvement in the course of the illness resulted, but survival may have been slightly prolonged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01267425
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    Paper (German National Licenses)
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