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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 38-42 
    ISSN: 1432-1335
    Keywords: Osteogenic sarcoma: Roentgenologic criteria for follow-up ; Roentgenologic signs for tumor involution ; Angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions Comparing the roentgenologically estimated involution of a primarily conservatively treated osteosarcoma with the histologic regression grading, the coincidence is 72%. When including grades I to III in one group and IV to VI in an other, the accuracy of roentgenologic evaluation rises to 88%. Based on a typical roentgenologic follow-up of tumors, that react well to the medical treatment, criteria were determined to allow an estimation of the degree each osteosarcoma responds to the therapy. Difficulties still remain with some tumors, especially where no control angiography was done. Computerized tomography and nuclearmedical techniques will probably provide additional diagnostic help in these and other cases.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 51-54 
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Preoperative high-dose-methotrexate-chemotherapy ; Angiography after chemotherapy ; Angiographic-pathologic comparison after chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2161
    Keywords: Osteosarcoma ; Chemotherapy ; Plain film radiography ; Angiography ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prognosis of osteosarcoma has improved significantly with recent advances in chemotherapy. Evaluation of the effect of chemotherapy is important for optimal timing of surgery, for selecting an alternative drug regimen in instances of poor response to chemotherapy and for testing combinations of new drugs. The purpose of this paper is to define the value of plain radiographs and angiography in assessing tumor response to chemotherapy. Studies were obtained before and after chemotherapy. The radiographic results were correlated with histologic evaluation of the resected specimen. Patients with less than 10% residual viable tumor in the resected bone were designated “responders” and patients with more than 10% of remaining viable tumor were “nonresponders”. Angiographic appearances correctly separated 15 patients with good response to chemotherapy from seven patients who were not responsive. Conversely, comparison of plain radiographs obtained before and after chemotherapy did not allow a reliable differentiation between patients with good, poor, or no response to chemotherapy. The current role of angiography in the management of patients with osteosarcoma is discussed. It is concluded that — in contrast to plain film radiography — angiography is an accurate method for assessing the response of osteosarcoma to chemotherapy.
    Type of Medium: Electronic Resource
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