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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 19 (2004), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pitch-onset response (POR) is a negative component of the auditory evoked field which is elicited when the temporal fine structure of a continuous noise is regularized to produce a pitch perception without altering the gross spectral characteristics of the sound. Previously, we showed that the latency of the POR is inversely related to the pitch value and its amplitude is correlated with the salience of the pitch, suggesting that the underlying generators are part of a pitch-processing network [Krumbholz, K., Patterson, R.D., Seither-Preisler, A., Lammertmann, C. & Lütkenhöner, B. (2003) Cereb. Cortex,13, 765–772]. The source of the POR was located near the medial part of Heschl's gyrus. The present study was designed to determine whether the POR originates from the same generators as the energy-onset response (EOR) represented by the N100m/P200m complex. The EOR to the onset of a noise, and the POR to a subsequent transition from noise to pitch, were recorded as the time interval between the noise onset and the transition varied from 500 to 4000 ms. The mean amplitude of the POR increased by ≈ 5.9 nA.m with each doubling of the time between noise onset and transition. This suggests an interaction between the POR and the EOR, which may be based on common neural generators.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 6 (1994), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Movement-related neuromagnetic fields from eight healthy human subjects were investigated in a Bereitschaftspotential paradigm. The three conditions studied were right-sided mouth, index finger and foot movement. The neuromagnetic field patterns corresponding to the motor field and the movement-evoked field I were analysed using a moving dipole model. For both components a somatotopic organization was found: the estimated dipole locations for the mouth were more lateral and those for the foot more medial than the estimated dipole positions for the index finger movement. With regard to possible clinical applications, e.g. non-invasive mapping of the sensorimotor cortex and studies of plasticity of the motor function, the present results suggest that the investigation of movement-evoked field I for the index finger condition is most likely to yield further results.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0165-1781
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 52 (1985), S. 409-416 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A statistical analysis of a weighted averaging procedure for the estimation of small signals buried in noise (Hoke et al. 1984a) is given. The weighting factor used by this method is in inverse proportion to the variance estimated for the noise. It is shown that, compred to conventional averaging, weighted averaging can improve the signal-to-noise ratio to a high extent if the variance of the noise changes as a function of time. On the other hand, uncritical application of the method involves the danger that the signal amplitude is underestimated. How serious this effect is depends on the number of degrees of freedom available for the estimation of the weighting factor. The effect can be neglected, if this number is sufficiently increased by means of an appropriate preprocessing.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 67 (1992), S. 1-10 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A theory has been developed which allows the estimation of the probability density of a discharge, given that an arbitrary condition is fulfilled. It is shown that the common methods for the evaluation of a post-stimulus time (PST) histogram and a hazard function can be considered as special applications of this theory. Whereas the usual hazard function shows how the probability of a discharge depends on the time elapsed since the last discharge, generalized hazard functions proposed in the present paper allow to reveal also the influence of the last but one discharge, the last but two discharge, and so on. In contrast to the usual method for the estimation of a hazard function, the applicability of the procedures proposed here is not restricted to stationary discharge activity. Some elementary applications are illustrated by analysing simulated discharge activity mimicing the response of a single auditory-nerve fiber to a high-intensity tone burst.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 223 (1979), S. 295-297 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The compound action potential of the auditory nerve can be conceived as a convolution integral of the firing probability densities of the auditory nerve fibres and a unit response. The probability densities can be derived directly — that means bypassing a time consuming model of the mechanical to neural transduction — from the displacement of the basilar membrane, regarding the response of the basilar membrane as the input of a cascade of nonlinearities. In particular we investigated the influence of an absolute refractory period on the probability of firing.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 227 (1980), S. 519-522 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The deconvolution technique of the compound action potential of the auditory nerve consists of a first deconvolution with the unit response, a logarithmic transformation, a second deconvolution with the normalized discharge pattern, and a linear transformation. The simplifying assumptions contained in the process are valid for infinitely short stimuli: The inherent error is growing with increasing duration of the stimulus signal. Similar assumptions can be made for stimuli of sufficiently narrow bandwidth if one interchanges the nonlinear transformation and the second deconvolution. Under these conditions, the error will be within tolerable limits. Application of this method would mean a considerable improvement in the evaluation of compound action potentials elicited by low-frequency tone pulses (carrier frequency 〈 1000 Hz). The principle and limits of the method are outlined, its efficiency with human compound action potentials elicited by Gaussian tone pulses are shown.
    Type of Medium: Electronic Resource
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