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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructure of the Node of Ranvier (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 575-577 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE theory of saltatory conduction in peripheral myelinated nerve fibres of mammals is now generally accepted1'2. The myelin sheath is considered to act as an insulator confining the active generation of current to the nodes of Ranvier, the propagation of the impulse along the internode being ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/199575a0
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  • 2
    Electronic Resource
    Electronic Resource
    Paranodal Apparatus of Peripheral Myelinated Nerve Fibres Of Mammals (1963)
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 670-673 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the uncomplicated internodal regions of peripheral myelinated nerve fibres of mammals, the axon and its sheath of compact myelin are approximately cylindrical and their ultra-structure as revealed by electron microscopy is well known1-3. Less attention has been paid to the distribution, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/198670a0
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  • 3
    Electronic Resource
    Electronic Resource
    Metabolically dependent blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 630-635 
    Details
    ISSN: 1432-0533
    Keywords: Blood-brain barrier ; Dinitrophenol ; Gadolinium ; Lanthanum ; Vesicle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have studied chronic relapsing experimental allergic encephalomyelitis (CREAE), a model of immune-mediated demyelination, using gadolinium (Gd)-enhanced magnetic resonance imaging in vivo and the bood-brain barrier (BBB) markers, lanthanum nitrate and Gd nitrate, histologically. In regions of the spinal cord showing Gd enhancement, there was evidence for vesicular transport as a mechanism of BBB breakdown in CREAE, shown by an increased number of endiothelial vesicles containing lanthanide (lanthanum or Gd, whichever had been perfused) and deposition of tracer in the perivascular space; tight interendothelial junctions remained intact. Prior perfusion with 2,4-dinitrophenol, a metabolic inhibitor, suppressed the appearance of endothelial vesicles containing lanthanide and tracer in the perivascular space. We conclude that an important contribution to BBB breakdown in CREAE is mediated by a metabolic change in the endothelial cells associated with increased vesicular transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299413
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  • 4
    Electronic Resource
    Electronic Resource
    Emery-dreifuss syndrome (1986)
    Springer
    Journal of neurology 233 (1986), S. 108-114 
    Details
    ISSN: 1432-1459
    Keywords: Emery-Dreifuss muscular dystrophy ; Scapuloperoneal syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A young adult male is described with muscular dystrophy of probable X-linked recessive inheritance. An onset of muscle weakness in late adolescence was preceded by contractures of the neck and elbows dating back to childhood. The distribution of muscle weakness was proximal in the upper limbs and both proximal and distal in the lower. The mixed pattern of muscle involvement in the legs favours the view that cases of Emery-Dreifuss muscular dystrophy with proximal weakness in both the upper and lower limbs and X-linked scapuloperoneal muscular dystrophy represent the same disorder. A muscle biopsy in the present case showed unique appearances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313856
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  • 5
    Electronic Resource
    Electronic Resource
    The fine structure of the equatorial regions of developing muscle spindles in the rat (1972)
    Springer
    Journal of neurocytology 1 (1972), S. 189-210 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of developing muscle spindles in the gastrocnemius muscles of young Wistar rats has been examined at stages from 18 days gestation to 14 days after birth. Initial simple contacts between large unmyelinated intramuscular nerve terminals and apparently undifferentiated single myotubes at 18 days gestation led to the encirclement of the myotube by the nerve terminal, with concurrent extension of the nerve sheath to form a unilamellar capsule around the innervated region. Subsequent proliferation and fusion of satellite myoblasts associated with the innervated myotube gave rise to a succession of further intracapsular myotubes. At birth the original myotube and its first formed companion had differentiated into recognizable ‘nuclear bag’ intrafusal fibres, and by the third post-natal day a second generation of smaller diameter ‘nuclear chain’ myotubes could be distinguished. These developing intrafusal muscle fibres remained in a tightly packed bundle, having numerous interlocking pseudopodial extensions of their superficial cytoplasm, until some 3–6 days after birth, the sensory nerve terminal enwrapping the external surface of the whole bundle. Lateral separation of the intrafusal fibres during the second post-natal week was accompanied by the acquisition of individual sensory innervation, the development of an axial sheath distinct from the now multilamellar capsule, and the first appearance of the subcapsular space. The fine structure of the developing sensory nerve terminals closely resembled that of mature spindle terminals, having dense amorphous cytoplasm containing many small mitochondria and 40–60 nm vesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01099184
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural localization of sympathetic axons in experimental rat sciatic nerve neuromas (1996)
    Springer
    Journal of neurocytology 25 (1996), S. 573-582 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructural localization of sympathetic axons was investigated in normal rat sciatic nerves and experimental sciatic nerve neuromas. The best ultrastructural localization of noradrenaline in the dense-cored vesicles of sympathetic axons was accomplished following pretreatment of rats with nialamide and 5-hydroxy dopamine, followed by fixation according to the modified chromaffin technique of Tranzer and Richards (1976). After such preparation, sympathetic axons containing 5-hydroxy dopamine-labelled dense-cored vesicles could be identified in normal sciatic nerve. Large accumulations of labelled dense-cored vesicles were also found in acute neuromas, up to 1 week after nerve section. Much smaller numbers of densecored vesicles could be identified in chronic neuromas from 2 to 3 weeks following nerve section. Sympathetic axons could also be identified following electron probe X-ray microanalysis of the tissue sections, using chromium detection as the marker for the noradrenaline-containing dense-cored vesicles. Unusual configurations of Schwann cell subunits, which enclosed myelinated fibres and sympathetic axon sprouts within the same basal lamina, were identified in the acute neuromas, 3–7 days after nerve section. Such configurations may be of relevance to the pathophysiological interaction which develops between sympathetic efferent and sensory fibres in peripheral nerve neuromas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284825
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