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  • 1
    Electronic Resource
    Electronic Resource
    Dermoscopy of Bowen's disease (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Dermoscopy improves the diagnostic accuracy in pigmented skin lesions, but it is also useful in the evaluation of nonpigmented skin tumours as it allows the recognition of vascular structures that are not visible to the naked eye. Bowen's disease (BD) or squamous cell carcinoma in situ is usually nonpigmented, but may also rarely be pigmented.Objective  To describe the dermoscopic features in a series of pigmented and nonpigmented BD.Methods  Dermoscopic images of 21 histopathologically proven BD were evaluated for the presence of various dermoscopic features. Each lesion was photographed using the Dermaphot (Heine Optotechnik, Herrsching, Germany), at 10-fold magnification, and the colour slides were scanned to digital format using a Kodak Photo CD system.Results  The majority of cases of BD revealed a peculiar dermoscopic pattern characterized by glomerular vessels (90%) and a scaly surface (90%). In addition, in pigmented BD small brown globules regularly packed in a patchy distribution (90%), and structureless grey to brown pigmentation (80%) were observed.Conclusions  Dermoscopy can be helpful for diagnosing BD because of the presence of repetitive morphological findings such as glomerular vessels and a scaly surface. In pigmented BD, small brown globules and/or homogeneous pigmentation can be seen as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05924.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tierexperimentelle Untersuchungen zur Frage der Riesenzell-Hepatitis bei Babyratten nach Galaktosamingabe an schwangere Ratten (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 1072-1073 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This investigation was undertaken to produce the morphological picture of a giant cell hapatitis in new born infants by application of galactosamine in pregnant rats. For the first time the diaplacentar transmission of D-galactosamine-1-C14-hydrochloride and its incorporation into the fetal liver could be demonstrated. As compared to the normal control group the animals showed typical histological alterations. At the same time the animals treated with galactosamine revealed a significant decrease of protein concentration of liver tissue.
    Notes: Zusammenfassung Durch die Galaktosamingabe an schwangere Ratten, wurde versucht, bei den Neugeborenen eine der menschlichen Riesenzellhepatitis ähnliches morphologisches Bild hervorzurufen. Mittels D-Galaktosamin-1-C14-hydrochlorid wurde erstmals die diaplacentare Passage und die Inkorporation in die fetale Leber nachgewiesen. Im Vergleich zu einem Kontrollkollektiv kam es zuhistologischen Veränderungen, gleichzeitig fand sich eine signifikante Proteinkonzentrationsabnahme in der Leber in den durch Galaktosamin geschädigten Tieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01497218
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Die Hämostase im Verlauf der Galaktosaminhepatitis (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 386-387 
    Details
    ISSN: 1432-1440
    Keywords: Galactosamine hepatitis ; acute liver necrosis ; blood coagulation ; Galaktosaminhepatitis ; akute Lebernekrose ; Blutgerinnung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 21 Kaninchen erhielten 1 g Galaktosamin/kg Körpergewicht intravenös injiziert. Das Gerinnungs-system (Faktor II, X, V, VIII, Fibrinogen und Thrombocyten) wurde vor Galaktosamingabe und kurz vor dem Tod der Tiere untersucht. Nur 6 Kaninchen lebten 48 Std nach der Galaktosamininjektion. Während der Galaktosaminhepatitis, die mit den Zeichen einer Lebernekrose verlief, zeigten der Prothrombinkomplex, die Faktoren V und VIII einen signifikanten Abfall. Somit ist eine Bildungsstörung der Gerinnungsfaktoren nachgewiesen, eine Umsatzstörung läßt sich jedoch nicht ausschließen.
    Notes: Summary 21 rabbits were treated with 1 g galactosamine/kg. The coagulation system (factors II, X, V, VIII, fibrinogen, blood platelets) was investigated before injection and shortly before death. 6 rabbits still survived 48 hours after galactosamine injection. The results showed a significant decrease of the prothrombin complex, and of factors V and VIII during hepatitis with liver necrosis. There seems to be a disturbance in the production of coagulation factors; a consumption coagulopathy is not excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486836
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    Paper (German National Licenses)
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