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  • 1
    Electronic Resource
    Electronic Resource
    The value of prognostic parameters for the stratification of advanced breast cancer patients (1982)
    Springer
    Journal of cancer research and clinical oncology 102 (1982), S. 289-299 
    Details
    ISSN: 1432-1335
    Keywords: Metastatic breast cancer ; Combination cytotoxic chemotheraphy ; Stratification parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One hundred seventy-five patients with metastatic breast cancer, treated with a combination chemotherapy (Cooper regimen), were analyzed retrospectively to identify the value of the traditional prognostic parameters (disease-free interval; menopausal status; dominant site of metastatic lesion) for the stratification of patients before randomization. Response rate and survival time were not significantly affected by the disease-free interval and menopausal status. A significant difference was detected among the three categories total extent of disease (according to Swenerton) was found to be the most important factor for predicting response and survival time after combination cytotoxic treatment. The differences between the dominant size of metastatic disease are mainly influenced by different size of metastatic spread. Therefore, there is found a significant correlation between the different types of dominant lesions and total extent of disease. In conclusion, the particular sites of metastatic spread seem to be of less importance than overall extent of disease in predicting the outcome. A critical evaluation of the three traditional stratification parameters and introduction of a semiquantitative estimation of total tumor burden as a new stratification parameter seems to be necessary when planning and comparing future trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411349
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Hemmung der Glukose und Leucin-Resorption durch Somatostatin beim Hund (1981)
    Springer
    Research in experimental medicine 178 (1981), S. 241-246 
    Details
    ISSN: 1433-8580
    Keywords: Somatostatin (growth hormone release inhibitory factor) ; Small bowel absorption ; Glucose ; Leucin ; Somatostatin ; Dünndarmresorption ; Glukose ; Leucin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer Resorptionsstudie an der isolierten Thiry Vella-Schlinge am wachen Hund wurde der Einfluß von Somatostatin (SST) auf die Dünndarmresorption von Glukose und Leucin untersucht. Unter SST wurde eine signifikante, aber nicht totale Hemmung der Glukoseresorption und eine prozentuell geringere signifikante Verminderung der Leucinresorption gefunden.
    Notes: Summary Small bowel absorption of glucose and leucin was investigated under the influence of somatostatin (SST) using an isolated Thiry Vella loop in the unrestrained dog. SST infusion significantly reduced glucose and leucin absorption, inhibiting glucose absorption more than that of leucin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851013
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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