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  • 1
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Transkranielle Dopplersonographie ; Ergometerbelastung ; Chronischer Kopfschmerz vom Spannungstyp ; Key words Transcranial Doppler sonography ; ergometer test ; tension type headache
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the etiopathology of tension type headache, vascular and autonomic disorders are discussed. Fifteen patients with chronic tension type headache according to the criteria of the IHS were investigated using the TCD-ergometer-test – a method used to evaluate the myogenic mechanism of cerebrovascular autoregulation – and the results were compared with the findings in fifteen healthy control subjects. The patients’ Mean Flow Velocity (TAVmean) and Resistance Index (RI) at rest and after exercise were significantly decreased (p 〈0,05). During exercise they normalized. The patients’ endtidal pCO2 at rest and during exercise was significantly lower than the corresponding values of the control group (p 〈0,05). Regarding blood pressure elevation and heart rate increase during exercise both groups did not differ significantly (p 〉0,05). These findings suggest that patients with tension type headache have a diminished vascular tone in the cerebral vessels at rest which is normalised during exercise. The reduced endtidal pCO2 is considered as a physiological response to increase vascular tone via metabolic mechanism of cerebrovascular autoregulation. In conclusion it is suggested that therapeutic procedures which activate sympathetic autonomic nervous function to train cerebral vessels should be more carefully considered.
    Notes: Zusammenfassung In der Ätiopathogenese des chronischen Kopfschmerzes vom Spannungstyp (CKST) werden unter anderem vaskuläre und autonome Faktoren diskutiert. Wir untersuchten mit dem TCD-Ergometertest (Streß-TCD – eine Methode zur Beurteilung des myogenen Mechanismus der zerebrovaskulären Autoregulation) 15 Patienten mit chronischem Kopfschmerz vom Spannungstyp (entsprechend den Kriterien der IHS) und verglichen die Befunde mit denen von 15 gesunden Kontrollpersonen. Die mittlere Strömungsgeschwindigkeit (TAVmean) war bei den CKST-Patienten unter Ruhebedingungen und nach Belastung signifikant vermindert (p 〈0,05). Der Resistance-Index (RI) als Maß des peripheren Gefäßwiderstandes war ebenfalls bei der Patientengruppe unter Ruhebedingungen und nach 5minütiger Erholungsphase signifikant vermindert (p 〈0,05). Während der Belastungsphase glichen sich TAVmean und RI den Werten der Kontrollgruppe an. Der endexpiratorische pCO2 der Patienten lag unter Ruhe und Belastungsbedingungen signifikant unter dem jeweiligen Wert der gesunden Probanden (p 〈0,05). Bezüglich des Verhaltens von Blutdruck und Herzfrequenz unterschieden sich die Patienten nicht signifikant von den gesunden Probanden (p 〉0,05). Diese Befunde sprechen für einen verminderten basalen Vasotonus des zerebralen Gefäßsystems bei CKST-Patienten, der sich unter Belastung normalisiert. Der verminderte endexpiratorische pCO2 der Patienten ist als Ausdruck einer physiologischen Gegenregulation über den metabolischen Autoregulationsmechanismus anzusehen mit dem Ziel der Vasotonuserhöhung. Aufgrund dieser Resultate sollten im therapeutischen Kontext vermehrt physiotherapeutische gefäßtrainierende Verfahren in Betracht gezogen werden.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 124 (1996), S. 241-244 
    ISSN: 1432-2072
    Keywords: Cutaneous microcirculation ; Laser Doppler flowmetry ; Inspiratory gasp response ; Amitriptyline ; Fluoxetine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cutaneous microcirculation was investigated in 30 major depressed inpatients receiving either 150 mg amitriptyline (n=15) or 30 mg fluoxetine (n=15) as monotherapy, and in 15 normal control subjects matched for age and sex. The laser Doppler flux (LDF) was recorded while resting and under the condition of a sudden deep breath (“inspiratory gasp response”). In normal subjects this autonomic function test caused a marked decrement of LDF signal, which rapidly returned to the baseline value. In both groups of drug treated patients the decrements of LDF signal after a sudden deep breath did not differ from those found in the normal control subjects. However, in the amitriptyline-treated patients the return of LDF-signal to the baseline values was significantly delayed (P=0.0007), while patients treated with fluoxetine showed the same behaviour as normal subjects. With a discriminant analysis using the results of the inspiratory gasp responses, 100% of the amitriptyline treated patients were correctly classified. Since both groups of depressed patients revealed comparable depression scores, the differences found are probably due to the side effects of amitriptyline. Possible clinical implications of these findings are discussed.
    Type of Medium: Electronic Resource
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