ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
[2-p-Fluorophenylalanine]oxytocin (1a), desamino-[2-p-fluorophenylalanine]oxytocin (1b), and desamino-oxytocin (2) have been synthesised via intermediates containing S-acetamidomethyl-cysteine. The protected linear peptides were built up using both stepwise and fragment-condensation procedures, and the S-protecting groups were removed by iodine with simultaneous formation of the disulfide bridge. The uterotonic activities in vitro of the analogues have been determined. The close similarity of the 19F-NMR. spectra indicates that the p-fluorbenzyl side chain is freely exposed to the solvent in the disulfide-bridged hormone analogues as well as in their S-protected, acyclic precursors.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19740570215
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