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  • 1
    Digitale Medien
    Digitale Medien
    A beam expander facility for studying x-ray optics : Proceedings of the 4th international conference on synchrotron radiation instrumentation (1992)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 63 (1992), S. 1168-1171 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: The detailed study of the performance of full scale x-ray optics often requires the illumination of large areas. This paper describes a beam expander facility at the Daresbury Synchrotron Radiation Facility. It combines monochromatization and beam expansion in one dimension. The beam expansion is obtained from an extremely asymmetric reflection in a large single crystal of Si. An expansion of a factor of 50 was obtained in one dimension. The expanded beam of ∼85 mm is limited only by the crystal size. The facility is installed in a 12-m-long hutch. A specific application, in which a high throughput x-ray telescope will be studied, is described in detail.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1143124
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  • 2
    Digitale Medien
    Digitale Medien
    Temporal variation in the drift of plant litter and propagules in a small boreal river (2002)
    Oxford, UK : Blackwell Science Ltd
    Freshwater biology 47 (2002), S. 0 
    Details
    ISSN: 1365-2427
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: SUMMARY 1. Rivers are linear ecosystems across landscapes with an effective transport of organisms, sediment and organic matter. Dispersal is studied mostly during single events and for single species, and there is little knowledge on how the drift of plant litter and propagules varies within and between years for entire communities.2. We used floating traps for collecting waterborne plant litter and propagules in a small boreal river over 2 years. We installed the traps at four different locations along the river, and emptied them at least once a week during the ice-free season. We analysed propagule content by sorting and identifying species and through germination tests on bare soil.3. In total, we recorded at least 54 taxa in the samples, and the highest density recorded in one sample was 5000 propagules per 100 g litter (dry weight). Large temporal variations in litter and propagule transport were revealed, both within and between years.4. The longitudinal pattern was consistent between years, with an increasing mass of litter and number of propagule taxa downstream. The results highlight the importance of the temporal and longitudinal dimensions in river management.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2427.2002.00925.x
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  • 3
    Digitale Medien
    Digitale Medien
    Role of CD8+ Cell-Produced Anti-Viral Factors in Protective Immunity in HIV-2-Exposed but Seronegative Macaques Resistant to Intrarectal SIVsm Challenge (2001)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 53 (2001), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The cell-mediated immune response is likely to be important in controlling HIV/SIV infection. There is evidence that β-chemokines and other, as yet unknown, anti-viral factors play a role in host defence against HIV infection. We reported previously that HIV-2 exposed but seronegative cynomolgus macaques developed SIV-specific cytotoxic T lymphocytes and were resistant to mucosal SIV challenge. The aim of this study was to examine CD8+ cell-dependent production of β-chemokines and other anti-viral factors in these macaques. The animals, selected from among 17 monkeys enrolled in two separate experiments, were either treated with an anti-viral drug or immunized passively with HIV-2 antibody-positive serum. Three of these monkeys were protected against repeated HIV-2 challenge and were also able to control SIV infection 3 years later. Control samples were obtained from four macaques that became SIV infected and from 39 naïve animals. The three resistant monkeys showed significantly higher production of RANTES and MIP-1α than the 39 naïve animals. In addition, SIV infection was suppressed by CD8+ cell culture supernatants of these monkeys. However, antibodies to chemokines only partially neutralized CD8+ cell-mediated SIV suppression indicating that the anti-viral activity observed in these monkeys was the result of combined action of several inhibitory factors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-3083.2001.00865.x
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  • 4
    Digitale Medien
    Digitale Medien
    Basaloid squamous cell carcinoma of the palate (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 25 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb01576.x
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  • 5
    Digitale Medien
    Digitale Medien
    CD14 and development of atopic disease at 2 years of age in children with atopic or non-atopic mothers (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background CD14, a myeloid cell marker and LPS receptor has been acclaimed to play a role in development and manifestation of atopic allergy, as the gene encoding CD14 is located in a chromosomal region linked to total IgE levels and atopic disease.Objective To investigate the levels of soluble (s) and membrane bound (m) CD14 in cord blood and at 2 years of age from children with atopic or non-atopic mothers and relate these parameters to atopy development at 2 years of age.Methods Blood samples were collected at delivery (cord blood) and at 2 years of age among infants with atopic (n = 41) and non-atopic (n = 32) mothers. Blood samples were also obtained from mothers at the same occasions. Levels of sCD14 and total IgE were measured in plasma, and percentages of CD14+ cells were measured in cord and peripheral blood mononuclear cells.Results We observed significant differences in sCD14 levels in cord blood, where children with atopic mothers had the highest levels. The same pattern could be observed in the mothers at delivery. At 2 years of age no significant differences in sCD14 levels were observed between children with atopic mothers and children with non-atopic mothers and no association between sCD14 and atopic disease was found. Further, we observed large differences in sCD14 and mCD14 with respect to age, where newborns displayed a higher frequency of CD14+ cells compared with the 2-year-olds and the mothers. The reverse was observed for sCD14, with significantly lower values in cord blood than those seen in the 2-year-olds and mothers.Conclusion Based on our findings, we suggest that CD14 could be involved in the regulation of IgE production, but that it might also be important for the maturation and development of the neonatal immune system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01629.x
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  • 6
    Digitale Medien
    Digitale Medien
    Levels of soluble CD30 in cord blood and peripheral blood during childhood are not correlated with the development of atopic disease or a family history of atopy (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background The CD30 molecule has been linked to Th2 responses. Furthermore, elevated levels of the soluble form of CD30 (sCD30) in blood as well as of the expression of CD30 on the plasma membrane of T cells are associated with atopic disease.Objective To assess the potential usefulness of sCD30 levels as a prognostic indicator of and/or diagnostic marker for the development of atopic disease in children.Methods sCD30 levels in cord blood and peripheral blood from 36 2-year-old (10 atopic and 26 non-atopic) and 74 7-year-old (35 atopic and 39 non-atopic) children were determined employing an ELISA procedure. Atopy was diagnosed on the basis of clinical evaluation in combination with a positive skin prick test.Results No significant correlation between sCD30 levels in cord blood and the development of atopic disease at 2 or 7 years of age was observed. At 7 years of age, the circulating sCD30 levels in children with atopic disease (median 41 U/mL, range 6–503 U/mL) did not differ from the corresponding values for non-atopic subjects (median 41 U/mL, range 8–402 U/mL). The same was true for children at 2 years of age. Furthermore, the sCD30 levels of children who had developed atopic eczema/dermatitis syndrome by the age of 7 years (median 49 U/mL, range 14–503 U/mL) were not significantly elevated in comparison with those of the non-atopic children. Finally, neither sCD30 levels in cord blood nor peripheral blood at 2 or 7 years of age could be linked to a family history of atopy.Conclusion These findings indicate that the sCD30 concentration in cord blood is not a reliable prognostic indicator of, nor a useful diagnostic marker for, atopic disease in children up to 7 years of age. If such correlations do exist, they might be masked by age-dependent variations in the circulating levels of sCD30, which may reflect individual differences in the maturation of children's immunological responses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01792.x
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  • 7
    Digitale Medien
    Digitale Medien
    Low numbers of interleukin-12-producing cord blood mononuclear cells and immunoglobulin E sensitization in early childhood (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Successful pregnancies are associated with skewing towards a Th2 cytokine profile. Cytokine responses to allergens can be detected in cord blood mononuclear cells (CBMC), suggesting allergen priming already in utero.Objective To investigate the cytokine profile in CBMC after in vitro stimulation with allergens and to relate the responses to the outcome in terms of allergic disease at 2 years of age.Methods CBMC were isolated from 82 children. The responses to ovalbumin (OVA), birch, cat and phytohaemagglutinin (PHA) were investigated by the ELISpot technique. The numbers of IFN-γ-, IL-4- and IL-12-producing CBMC were counted for each stimulation. The children were followed prospectively; skin prick test (SPT) and RAST towards food and inhalant allergens were assessed at 24 months of age.Results Sixteen (19.5%) children were classified as IgE sensitized (positive SPT; 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:09547894:CEA1896:ges" location="ges.gif"/〉3 mm and/or RAST; 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:09547894:CEA1896:ges" location="ges.gif"/〉0.35 kUA/L). The numbers of IL-12-producing CBMC after stimulation with birch, OVA and cat were lower among IgE-sensitized children, statistically significant for cat. IFN-γ-producing cells, did not differ in numbers between the sensitized and non-sensitized children. Children who had atopic eczema/dermatitis syndrome (AEDS) during the observation (n=53) had significantly lower numbers of IFN-γ-producing CBMC after stimulation with OVA and cat than their non-AEDS counterparts.Conclusions Although the numbers of infants in our study are limited our data suggest that a low number of IL-12-producing CBMC is associated with IgE sensitization during early childhood and that a reduced number of IFN-γ-producing CBMC promotes the development of AEDS during the first 2 years of life.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01896.x
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  • 8
    Digitale Medien
    Digitale Medien
    Class separation of buildings with high and low prevalence of SBS by principal component analysis (2004)
    Oxford, UK : Munksgaard International Publishers
    Indoor air 14 (2004), S. 0 
    Details
    ISSN: 1600-0668
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0668.2004.00203.x
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  • 9
    Digitale Medien
    Digitale Medien
    Drying of linseed oil paints: the effects of substrate on the emission of aldehydes (2003)
    Oxford, UK : Munksgaard International Publishers
    Indoor air 13 (2003), S. 0 
    Details
    ISSN: 1600-0668
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1034/j.1600-0668.2003.00193.x
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  • 10
    Digitale Medien
    Digitale Medien
    A case of allergy to cow's milk hydrolysate (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We here report a girl, now 3 years old, who has suffered from severe food allergy since her first year of life. She was strongly allergic to cow's milk, and had high levels of IgE antibody (AB) to casein (210 kU/l), β-lactoglobulin (43 kU/l), and α-lactalbumin (23 kU/l) at 12 months of age. In addition, at the same age, she showed positive (2–4+) skin prick reactions to both unboiled and boiled formulas (Profylac, Nutramigen, and Neocate), besides being positive in RAST to Nutramigen (0.6 kU/l). During the first 3 years, IgE Ab levels against casein and Nutramigen increased to 310 and 1.6 kU/l, respectively. Furthermore, at 3 years of age, she had positive RAST to 14 of 15 tested food allergens, being negative only to codfish. Assessment of eosinophil-related markers revealed high total eosinophil count, increased eosinophil activity, and a low ratio of interferon (IFN)-γ:IL-5, indicating enhanced IL-5 production. The food allergy was correlated to poor weight gain and increasing problems with atopic allergy in the airways.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00236.x
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