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  • 1
    ISSN: 1432-1076
    Keywords: Key words Lung function ; Conductive airways ; Sudden infant death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A reduction in specific airway conductance has been reported in infants with a history of an apparent life-threatening event (ALTE). It is unclear, however, whether this reflects upper or lower airway narrowing. We performed a controlled study to determine small airway patency in infants with ALTE. Lung function tests were performed in 26 infants with a history of ALTE and 27 healthy controls. Partial expiratory flow-volume curves were obtained during quiet sleep using the rapid chest compression technique; thoracic gas volume (TGV) and expiratory airway resistance (RAW) were measured by whole body plethysmography. Compliance of the respiratory system (Crs) was measured using the single breath occlusion technique. The median maximal flow at functional residual capacity (V˙maxFRC) was 85 ml/s (range 10–198 ml/s) in patients and 123 (range 47–316 ml/s) in controls (P = 0.003). V˙maxFRC corrected for TGV was 0.5 s−1 (range 0.06–1.3 s−1) and 0.9 s−1 (range 0.4–1.8 s−1), respectively (P = 0.001). TGV, RAW and Crs were not significantly different between patients and controls. Conclusion Reduced small airway patency may play a role in the pathogenesis of ALTE.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Ventilation, negative extrathoracic pressure ; Cardiac surgery ; Glenn shunt ; Pulmonary infection ; Respiratory syncytial virus ; Pseudomonas aeruginosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following a Glenn shunt, an infant required mechanical ventilation (IPPV) for pneumonia, a phrenic nerve palsy and chylothoraces. In order to improve her deteriorating clinical condition, we used continuous negative extrathoracic pressure (CNEP) to minimise the deleterious effects of IPPV on pulmonary blood flow. She was sucessfully weaned from IPPV and supported with CNEP.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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