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  • 1
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dexpanthenol is popular in treating various dermatoses and in skin care, but few controlled clinical trials have been performed. We investigated the efficacy of dexpanthenol in skin protection against irritation in a randomized, prospective, double-blind, placebo-controlled study. 25 healthy volunteers (age 18–45 years) were treated for the inner aspect of both forearms with either Bepanthol® Handbalsam containing 5% dexpanthenol or placebo ×2 daily for 26 days. From day 15–22, sodium lauryl sulfate (SLS) 2% was applied to these areas ×2 daily. Documentation comprised sebumetry, corneometry, pH value and clinical appearance (photographs). 21 volunteers completed the study, 3 were excluded because of non-compliance and 1 experienced a non-study-related, severe, adverse event. Only corneometry yielded a statistically significant difference, with decreased values following SLS challenge at the placebo sites (P 〈 0.05). Intraindividual comparisons showed superior results at the dexpanthenol-treated sites in 11 cases and in only 1 case at the placebo site. 6 volunteers experienced an irritant contact dermatitis, with more severe symptoms at the placebo site in 5 cases. In conclusion, dexpanthenol exhibits protective effects against skin irritation. The initiation of a study to evaluate the efficacy of dexpanthenol in preventing irritant occupational contact dermatitis under real workplace conditions is validated.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Hautinfektionen ; Antibiotikatherapie ; Bakterielle Infektionen ; Keywords Skin infections ; Antibiotic therapy ; Bacterial infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and Objective. For rational therapeutic recommendations the spectrum and resistance of bacteria in skin diseases were investigated. Patients/Methods. Within 4 months 911 swabs of dematoses possibly caused by bacteria were taken prospectively (481 outpatients, 430 inpatients) and the material cultured on standard media. The positive cultures including resistance screening of 210 swabs of 168 outpatients and of 175 swabs of 85 inpatients could be evaluated, the remaining cultures were sterile. Results. Staphylococcus aureus was the most frequent pathogen (outpatient 67%, inpatient 61% of all positive cultures), followed by streptococci (groups A and B; 25%). In patients Pseudomonas aeruginosa was the most common pathogen in leg ulcers and between the toes (45% and 70% respectively). 13% of the Staphylococcus aureus isolates were resistant to tetracyclines and erythromycin; one strain proved to be methicillin resistant. Conclusions. Cephalosporins (I. generation), penicillins with b-lactamase-inhibitors, and to a lesser extent isoxazoyl-penicillin and clindamycin can be recommended for the treatment of skin infections. Oral quinolones are suited for infections with gram-negative bacteria (such as beween the toes). The indications for systemic antibiotic therapy of leg ulcers should be restricted.
    Notes: Zusammenfassung Hintergrund und Fragestellung. Zur Erarbeitung rationaler Behandlungsrichtlinien wurde die Erreger- und Resistenzsituation potenziell bakteriell verursachter Hauterkrankungen erfasst. Patienten/Methodik. Innerhalb von 4 Monaten wurden 911 Abstriche entnommen (481 ambulant, 430 stationär) und das Untersuchungsmaterial auf Standardmedien angezüchtet. Bei 210 Abstrichen von 168 ambulanten Patienten sowie 175 von 85 stationären Patienten wurden Erreger einschließlich Antibiogramm ausgewertet, die übrigen waren steril. Ergebnisse. Staphylococcus aureus war am häufigsten nachweisbar (ambulant 67%, stationär 61% aller positiven Kulturen), gefolgt von Streptokokken (Gruppe A,B: 25%). In Ulzera bzw. im Zehenzwischenraum stationärer Patienten dominierte Pseudomonas aeruginosa (45 bzw. 70%). Durchschnittlich waren 13% der Staphylococcus-aureus-Isolate gegen Tetrazykline und Erythromycin resistent, ein Stamm war Methicillin-resistent. Schlussfolgerungen. Zur Behandlung von Hautinfektionen können in erster Linie Cephalosporine (I. Generation) und inhibitorgeschützte Penizilline, eingeschränkt Isoxazoylpenicilline und Clindamycin empfohlen werden. Orale Chinolone sind für Infektionen mit gramnegativen Erregern geeignet (Zehenzwischenraum). Die Indikation zur systemischen antibiotischen Therapie von Ulcera crurum ist restriktiv zu stellen.
    Type of Medium: Electronic Resource
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