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  • 1
    ISSN: 0378-1119
    Keywords: Recombinant DNA ; cDNA-library ; chromosome mapping ; exon/intron distribution ; nomenclature ; phylogenetic tree
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Orthopäde 28 (1999), S. 243-249 
    ISSN: 1433-0431
    Keywords: Key words Preoperative information • Computer based information system ; Schlüsselwörter Aufklärungsgespräch • Computergestützte Patienteninformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Verschuldete Defizite der ärztlichen Aufklärung machen einen ärztlichen Eingriff insgesamt rechtswidrig und führen deshalb im Grundsatz zur Haftung für alle Schäden. Zur Verminderung dieser Haftungsgefahren wurde ein computergestütztes Aufklärungskonzept entwickelt, mit dessen Hilfe eine individuell auf den Patienten bezogene Arbeitsunterlage erstellt wird. Anhand dieser Unterlage wird das eigentliche Aufklärungsgespräch geführt. Nach Unterschrift des Patienten steht das Schriftstück dem für die Aufklärung beweispflichtigen Arzt zum Nachweis des Aufklärungsinhalts zur Verfügung. Der langjährige Einsatz des Konzepts hat gezeigt, daß damit das Vergessen wesentlicher Punkte und Verständnisschwierigkeiten beim Patienten weitgehend ausgeschlossen werden können und damit eine hohe Aufklärungsqualität erreicht wird.
    Notes: Summary Culpable deficits of the preoperative information cause a complete illegality of the whole medical intervention and lead to liability for any resulting damage. In cases of controversy it's the physician's due to prove the correct preoperative information. To reduce these liability-risks a computer based information system has been developed. With its help an working sheet is provided which is individually adjusted for the patient. Based upon this record the real preoperative information takes place. After the patient signed the record the physician keeps it at his disposal for proving the contents of the preoperative information. The conception's use over many years shows that overlooking essential aspects and misunderstanding can grossly be excluded for the patient and a high quality of information can be reached.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 116 (1997), S. 41-45 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Analysis of the mechanisms of loosening of cemented stems by radiological long-term follow-up in 129 cases. The most important finding was the failure of the cement-metal interface (29.5%), which was correlated significantly with osteolysis (31 %). This suggests that the polyethylene debris reaches the bone through defects in the cement mantle (76.7%). In fact, the appearance of cement defects matches the number of identified osteolyses. This study shows that no permanent fixation can be achieved by the surface roughness of 2.0 μm Ra tried herein.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 116 (1996), S. 41-45 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Analysis of the mechanisms of loosening of cemented stems by radiological long-term follow-up in 129 cases. The most important finding was the failure of the cement-metal interface (29.5%), which was correlated significantly with osteolysis (31%). This suggests that the polyethylene debris reaches the bone through defects in the cement mantle (76.7%). In fact, the appearance of cement defects matches the number of identified osteolyses. This study shows that no permanent fixation can be achieved by the surface roughness of 2.0 μm Ra tried herein.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0584
    Keywords: Key words Multiple myeloma ; Prognostic marker ; Neural cell adhesion molecule ; β2-Microglobulin ; Interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A retrospective study was carried out to determine the diagnostic and prognostic value of the soluble form of the embryonal neural cell adhesion molecule NCAM (CD56) in paraproteinemia. NCAM, β2-microglobulin, and interleukin-6 levels were measured in the sera of 170 patients with paraproteinemia. Of these, 125 had multiple myeloma, 20 Waldenström's disease, and 25 monoclonal gammopathy of unknown significance. Serum NCAM proved superior to β2-microglobulin and interleukin-6 in distinguishing multiple myeloma from paraproteinemias of various causes, with a high specificity of 95.5% in detecting multiple myeloma, although with a low sensitivity of 40%. In multiple myeloma NCAM is significantly correlated with β2-microglobulin, paraproteinemia, and low albumin levels. For the determination of tumor load β2-microglobulin levels accord best with the Salmon and Durie classification scheme. When patients are grouped according to their clinical course, the disease development is reflected better by NCAM than by β2-microglobulin or interleukin-6. Survival data indicate that all three markers have prognostic potential. Prognostic accuracy with respect to overall survival is best with β2-microglobulin.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fifteen apparently unrelated Dutch families with familial adenomatous polyposis (FAP) also known as familial polyposis coli (FPC; McKusick No. 17510) were screened for linkage with the DNA probe C11p11 localized on chromosome 5q21–22 and previously reported to be closely linked to FAP (Bodmer et al. 1987; Leppert et al. 1987). In our study C11p11 was minimally informative, which is ascribable to its low heterozygosity in the North European populations. Of the above families, 12 were investigated also for linkage with D5S37 (DNA probe Pi227). Data from 11 of them were found to be informative and showed that FAP is closely linked to D5S37 previously localized on chromosome 5q21 (peak lod score 7.85 at a recombination fraction of 0.048 with 95% probability limits 0.005–0.145). Results discussed below indicate for the first time that the most likely location of the FAP gene is in the band 5q22 very close to 5q21, if not in the transitional zone between these two bands. The probe Pi227 recognizes 4 restriction fragment length polymorphism (RFLP) sites, exhibiting a total of 9 alleles with 24 theoretically possible haplotypes in the Dutch population. Therefore, this probe appears to have potential as a generally useful predictive marker for FAP until much closer and similarly useful markers become available.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We describe here the screening of a small group of apparently healthy individuals belonging to the tribal communities of Koya Dora and Konda Reddi. A remarkably high incidence of deletion and nondeletion α+ thalassemia mutants has been found with allele frequencies and distributions characteristic to each tribe. We have confirmed the strict relationship between Hb S levels and the number of α globin genes in double heterozygotes for the S gene and α thalassemia. In this population sample we did not find either heterozygous carriers of α0 thalassemia (deletion of both alpha genes in “cis”) or individuals showing hemolytic anemia due to inactivation of three α-globin genes (Hb H disease). Selection by malaria is most probably responsible for the prevalence of the various α+ thalassemia haplotypes among the two tribal populations of Andhra Pradesh.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 21 (1997), S. 1-3 
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Bien que les lésions nerveuses soient assez rares après l’implantation de prothèses totales de la hanche, il s’agit d’une complication grave pour le patient. Dans une étude rétrospective, on a analysé les résultats de 2723 endoprothèses totales: il y avait 61 cas de neuropathie postopératoires, 13 cas concernaient le nerf sciatique, 33 cas le nerf sciatique poplité externe et 15 cas le nerf crural. Le risque augmente d’une manière plus significative en cas de révision (3,06%) – surtout en cas de changements isolés du cotyle (8,5%) – qu’en cas d’implantation de prothèses primaires. Après une durée moyenne de 107 mois (11 – 240), 41 patients ont été interrogés sur leurs pertes fonctionnelles actuelles: 17% parlaient d’une récupération complète, 39% d’une récupération partielle, et 44% d’une absence de récupération.
    Notes: Summary. Although the incidence of post-operative nerve palsy after total hip replacement is rare, it is an important complication for the patient. In a retrospective study the results of 2713 hip arthroplasties were reviewed. Sixty-one cases (2.24%) of post-operative neuropathy were identified, 13 of the sciatic nerve, 33 of the peroneal nerve and 15 of the femoral nerve. The risk is significantly higher in revisions (3.06%), especially when exchanging the acetabular component (8.5%) rather than in primary arthroplasties (2.13%). After an average period of 107 months (11 – 240) from operation, 41 patients with nerve lesions were questioned about their subjective functional capacity: 17% had recovered completely, 39% had noticed an improvement, and in 44% there was no change; 56.1% complained of weakness and had a complete paralysis. In all cases there was dysfunction of sensibility. Another 17.1% had a sensibility defect without weakness. There was pain in 51.2%, paraesthesia in 34.1% and areas of complete anaesthesia in 19.5%. Altogether 61% of the 41 patients had either gait problems or were dependent on orthotic devices. In summary, only about a third of the patients studied achieved a satisfactory degree of functional recovery.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 9 (1985), S. 317-329 
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Two constitutive models for the simulation of fracture and fragmentation processes in rapidly loaded rocks are studied. The models were included in a wave propagation finite element code. The results obtained from the two models were compared by a study of the intensity and extent of fracturing obtained from two different configurations of explosive charge and reflecting surfaces in a plane strain problem. The evolution of the time dependent fracture pattern and fragmentation process is also presented.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
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