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  • 1
    Electronic Resource
    Electronic Resource
    Osteogenesis imperfecta and malignant hyperthermia (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 51 (1996), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a patient with osteogenesis imperfecta who developed tachycardia, metabolic and respiratory acidosis (pH 7.14, Pco2 8.4 kPa, BE 8.5 mmol.l-1) and hyperthermia up to 40°C during anaesthesia with barbiturates, fentanyl, pancuronium, and nitrous oxide. Malignant hyperthermia was suspected and the patient treated accordingly. Two years later the in-vitro contracture test for malignant hyperthermia was completely normal. We conclude that hypermetabolism in patients with osteogenesis imperfecta is due to unknown mechanisms other than malignant hyperthermia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1996.tb12619.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bispectral index monitoring: comparison of two types of electrode (2000)
    Oxford : Blackwell Science Ltd
    Anaesthesia 55 (2000), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bis-monitoring is a new method of monitoring anaesthetic depth. Bis-monitoring is easy to perform, but the Bis-monitor and the original, disposable electrodes are expensive. The aim of this study was to determine whether the original Zipprep electrodes could be replaced by the much cheaper electrocardiogram electrodes. We compared bispectral index measurements, conducted using both types of electrode in the same patients before anaesthesia, and during light and deep anaesthesia, in patients randomly allocated to receive either sevoflurane or propofol anaesthesia. We found very good agreement between the measurements from the two different sets of electrodes. The impedance in the electrocardiogram electrodes was higher than in the Zipprep electrodes, but this did not affect the bispectral index. No other problems with either type of electrode were detected. It is concluded that Zipprep electrodes can be replaced by electrocardiogram electrodes in normal clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2000.01206.x
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  • 3
    Electronic Resource
    Electronic Resource
    Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia (1993)
    [s.l.] : Nature Publishing Group
    Nature genetics 5 (1993), S. 51-55 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Central core disease (CCD) of muscle is an inherited myopathy which is closely associated with malignant hyperthermia (MH) in humans. CCD has recently been shown to be tightly linked to the ryanodine receptor gene (RYR1) and mutations in this gene are known to be present in MH. Mutation screening ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0993-51
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of prenalterol on cardiac performance and transmural myocardial perfusion in patients with chronic renal failure (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 287-292 
    Details
    ISSN: 1432-1041
    Keywords: prenalterol ; chronic renal failure ; metoprolol ; blood pressure ; cardiac index ; stroke volume index ; transmural myocardial perfusion ; left ventricular ejection fraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The acute haemodynamic effects of the beta-adrenoreceptor agonist, prenalterol, were studied in six patients with chronic end-stage renal failure. Prenalterol 0.8 mg, 1.6 mg, and 3.2 mg was administered i.v. as a bolus, and after the last dose the selective adrenergic beta-1-receptor antagonist metoprolol was administered i.v. in doses of 5 and 10 mg. The haemodynamic effects of the drugs were investigated using impedance cardiography and radionuclide angiocardiography. The main haemodynamic effects were a dose-related chronotropic effect, demonstrated by an increase in heart rate (26%; 〈0.05), and an inotropic effect, shown by an increase in stroke volume index (20%;p〈0.05) and left ventricular ejection time (12%;p〈0.05); the cardiac index was increased by 47% (p〈0.05). Transmural myocardial perfusion (DPTI/SPTI ratio) was decreased by 22% (p〈0.05) after prenalterol. It is concluded that prenalterol has positive inotropic and chronotropic effects in patients with chronic renal failure, that the improvement in left ventricular performance is at the expense of a decreased transmural myocardial perfusion, and that metoprolol is a specific antidote.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01037935
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    Paper (German National Licenses)
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