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Notes: It is well known that two different photobiologic processes mainly take place when the human skin is exposed to ultraviolet (UV) light. The long waves of UVA and visible light (320–400 nm) irradiation causes skin tanning by melanocytic activation and the short waves of UVB (280–320 nm) can elicit variety of biologic action in cutaneous keratinocytes, melanocytes and other skin component cells. The sensitivity to the UV lights is generally depending on the three kinds of the skin type classified by the proposal of Pathak et al. [1]. The skin sensitivity of Japanese population, however, seems to be different from that of Caucasian's population because of the differences in genetic background and skin color, as indicated by Satoh and Kawada [2]. They tried to classify into three groups as J-I (always burn and rarely tan), J-II (moderately burn and moderately tan) and J-III (never burn and always tan) by the skin types to UV lights for the sun-tanning and sun-burning. Comparing these two criteria, a general concern indicates that J-I–III may correspond to the skin type II–IV of the Fitzpatrick's classification, respectively. Based on the Japanese skin types, the incidence of skin cancers and precancerous lesions related to the long-term exposure of sun-light was epidemiologically estimated by Araki et al. [3]. According to their results for several years (1992–1998), the overall number of skin cancers and precancerous states in Japanese was demonstrated to be small in comparison with the incidence of Caucasian's population, even though the people sets in areas of higher ambient solar radiation. However, working outdoors having J-I and/or a history of severe sunburn during childhood were found to be important risk factors, particularly among people of over 60 years of age. Regarding skin cancers and sun-exposed areas, we compared between 20 patients with skin cancers (males 13 and females seven) (average 65 years old) (〈link href="#t1-14"〉Table I) and 24 controls (males 10 and females 14), who were selected as similar ages to the patients at random, in their skin types and life environments by a questionnaire system. The skin types of the patients were J-I (15%), J-II (40%), and J-III (35%) and those of controls were J-I (4.2%), J-II (62.5%), and J-III (4.2%), respectively. The patient group tended not to protect from sun exposure and most of them were farmers. UV exposure is known to induce modulation of the skin immune system which Langerhans cells decrease in number in the epidermis, and on the other hand it is supposed that interleukin IL-10 producing macrophages (CD11b+) expand in the dermis. Not only IL-10, but also tumor necrosis factor (TNF)-α from macrophages and mast cells in the dermis seem to increase and suppress Th1 immune responses of the epidermis and Th2 immune responses might be induced by UV irradiation [4]. Recently, it has been reported, however, that in patients with polymorphous light eruption (PLE), the expression of TNF-α, IL-4, and IL-10 is reduced by UVB irradiation and that PLE appearance is related to UVB-induced immunosuppression [5].〈tabular xml:id="t1-14"〉I〈title type="main"〉 Twenty patients with skin cancers (average ages: 65 years old) (Department of Dermatology, Fukushima Medical University Hospital, 2001–2002) 〈table frame="topbot"〉〈tgroup cols="2" align="left"〉〈colspec colnum="1" colname="col1"/〉〈colspec colnum="2" colname="col2"/〉〈thead valign="bottom"〉〈row rowsep="1"〉Skin cancersNumber of patients〈tbody valign="top"〉Malignant melanoma8Squamous carcinoma4Bowen's disease4Basal cell carcinomas3Eccrine porocarcinoma1Location of skin cancersSun-exposed areas9Non-exposed areas11Then, we attempted to study UVB effects on atopic disease and chronic inflamed skin diseases in the therapeutic advantage, although it is harmful for the patients to be cutaneous carcinogenesis. The epidermal keratinocytes are capable of producing CC chemokines in the local Th2 response, as seen in atopic dermatitis, mycosis fungoides, etc. [6]. Thymus and activated-related chemokine (TARC) is one of the chemokines produced by keratinocytes which selectively activate lymphocytes of Th2 subset expressing CCR4 (receptor for TARC) [7]. Accumulating evidence has suggested that these chemokines have primary pathogenic importance in Th2 skin diseases. In order to find the effects of UVB irradiation on the production of TARC, we used a human keratinocyte HaCaT cell line. As assessed by RT-PCR and ELISA, UVB irradiation significantly decreased the expression of TARC mRNA and protein in HaCaT cells stimulated with interferon-γ (IFN-γ) and TNF-α in a dose-dependent manner. The down-regulation of TARC expression may be mediated in part by activation of the particular transcription, signal transducer and activator of transcription 1 (STAT 1), since it has shown that STAT 1 DNA-binding was down-regulated by UVB irradiation. Our results suggest that STAT 1 and other transcription factors play an important biological role in immune system of human skin irradiated by UVB and may support the results of Kolgen et al. [5].In this point of view, UVB irradiation will be a therapeutic tool for skin diseases related to Th2 type reaction, such as atopic dermatitis, mycosis fungoides, etc., although we need to optimize adequately the use of UVB in patients with J-I skin type or those of whom have the episode of severe sun-burn after UVB irradiation.〈section xml:id="abs1-1"〉〈title type="main"〉References1. Pathak, M.A., Nghiem, P. and Fitzpatrick, T.B. Acute and chronic effects on the skin. In: Fitzpatrick's Dermatology in General Medicine, 5th edn (Freedberg, I.M., Eisen, A.Z., Wolf, K., Austen, K.F., Goldsmith, L.A., Katz, S.I. and Fitzpatrick, T.B. eds), pp. 1598–1607. McGraw-Hill, New York (1999).2. Satoh, Y. and Kawada, A. Action spectrum for melanin pigmentation to ultraviolet light, and Japanese skin typing. In: Brown Melanoderma: Biology and Diseases of Epidermal Pigmentation (Fitzpatrick, T.B., Wick, M.M. and Toda, K. eds), pp. 87–95. University of Tokyo Press, Tokyo (1986).3. Araki, K., Nagano, T., Ueda, M., Washio, F., Watanabe, S., Yamaguchi, N. and Ichihashi, M. Incidence of skin cancers and precancerous lesions in Japanese- Risk factors and prevention. J. Epidemiol. 9, S14–S21 (1999).4. Teunissen, M. B., Piskin, G., Nuzzo, S. et al. Ultraviolet B radiation induces a transient appearance of IL-4+ neutrophils, which support the development of Th2 responses. J Immunol. 168, 3732–3739 (2002).5. Kolgen, W., van Meurs, M., Jongsma, M. et al. Differential expression of cytokines in UVB-exposed skin of patients with polymorphous light eruption. Arch. Dermatol. 140, 295–302 (2004).6. Kakinuma, T., Sugaya, M., Nakamura, K., Kaneko, F., Wakugawa, M., Matsushima, K. and Tamaki, K. Thymus and activation-regulated chemokine (TARC/CCL17) in mycosis fungoides: serum TARC levels reflect the disease activity of mycosis fungoides. J. Am. Acad. Dermatol. 48, 23–30 (2003).7. Imai, T., Nagira, M., Tkagi, S. et al. Selective recruitment of CCR4-binding Th2 cells toward antigen-presenting cells by the CC chemokins thymus and activation-regulated chemokine and macrophage-derived chemokine. Int. Immunol. 11, 81–88 (1999).

Notes: Numerical simulations of frequency modulation (FM) reflectometry are carried out for the effects of density fluctuations on phase measurements. It is found that the fluctuation amplitude, the fluctuation frequency, the sweep time of a source, and the beat frequency of a mixer output play the important roles. The reliability of density profile measurement is investigated for various sweep times and local path lengths. It is demonstrated that the reconstructed density profiles seem to be improved when the sweep time is faster than 100 μs and the local path length is shorter than 1 m. The numerical simulations are compared with the experimental results obtained from a broadband FM reflectometer applied to the GAMMA 10 tandem mirror. © 1999 American Institute of Physics.

Notes: A millimeter-wave two-dimensional imaging array has been developed for diagnostics of magnetically confined plasmas. It is applied to the plug cell of the GAMMA 10 tandem mirror, and measures time evolution of radial and axial line-density and electron cyclotron emission (ECE) profiles in one plasma shot. The monolithic-type GaAs Schottky diode detector having an antenna and built-in amplifier on a GaAs substrate is newly fabricated using monolithic microwave integrated circuit (MMIC) technology. This novel detector is developed to attain high frequency response up to submillimeter-wave region and wideband heterodyne characteristics, and is expected to be applied to ECE imaging in a large helical device. The response of the detector is compared with that of the hybrid-type detector using beam-lead Schottky barrier diodes. The first experimental result of the ECE measurement is reported using a heterodyne radiometer with the MMIC detector. © 1999 American Institute of Physics.

Notes: The use of ultrashort pulses (full width at half-maximum=1–100 ps) as a source of broadband, time-resolved radiation has high potential for application in microwave diagnostics for fusion plasmas. Here we report on the ultrashort-pulse reflectometry system developed for electron density profile and fluctuation measurements on the GAMMA 10 tandem mirror. The four-channel system (selectable frequencies of 8–17 GHz at 1 GHz intervals) measures the double-pass time-of-flight from the vacuum window to the cutoff layer. The hardware has an uncertainty of ±40 ps and can be operated at a repetition rate of 400 kHz. The system is operational, however, data from plasma experiments is unavailable at the moment. Results from a single-channel O-mode system show time-of-flight measurements consistent with values calculated from profiles obtained by a scannable single-channel interferometer. Fluctuation measurements are also consistent with results from a Fraunhofer diffraction diagnostic. These results suggest that with further refinements, ultrashort- pulse reflectometry will yield a simple yet reliable diagnostic for fusion devices. © 1999 American Institute of Physics.

Notes: A time–frequency analysis of plasma turbulence is performed for the GAMMA10 tandem mirror plasma. The method is based on the decomposition of the reflectometer signal into a set of wavelets. Excellent resolution in the time–frequency domain, inherent to wavelet analysis, allowed us to observe fast changes in the instantaneous spectra of fluctuations, which would be averaged out if treated using conventional Fourier analysis. In order to estimate the propagation velocity of turbulent fluctuations, a wavelet cross-correlation function was calculated. Comparison of wavelet spectra, corresponding to different reflectometer channels, demonstrates the existence of short-time flashes of fluctuation intensity, as well as elongation of low-frequency disturbances along the magnetic field lines and their rotation in the E×B direction. Plasma fluctuations in the Alfvén range of frequencies sometimes propagate from the center towards the magnetic plugs with velocities close to 1000 km/s. In general, the wavelet spectra of plasma turbulence in the Alfvén range of frequencies, viewed by means of the microwave reflectometer, appear to be much more irregular than the corresponding spectra of magnetic field fluctuations obtained using magnetic probes. © 1999 American Institute of Physics.

Notes: A new method of plasma density profile reconstruction in microwave reflectometry is proposed and implemented on an X-mode broadband reflectometer of the GAMMA 10 mirror device with an ultrafast sweep rate of 10–20 μs. The proposed method makes use of the wavelet transform of the detected signal. Excellent resolution in the time-frequency domain, inherent to wavelet analysis, allows one to obtain a radial electron density profile for every frequency sweep. The electron density reconstruction algorithm, besides the wavelet transform of the reflectometer signal, also includes the calibration, profile initialization, and the solution of an integral equation, ultimately yielding the local values of the electron density. Calibration of the measured signal phase and profile initialization is performed using the independent results of microwave interferometry. Inversion of the integral equation is implemented utilizing the gradient method, numerically stable even for plasma regions with steep density gradients and density profile plateaus. A wavelet-based profile reconstruction algorithm is especially advantageous for monitoring transient plasma phenomena and fast processes, such as in pellet injection, ultrafast swept reflectometry, and short pulsed reflectometry. © 1998 American Institute of Physics.

Notes: A broadband microwave reflectometer was applied to the GAMMA 10 tandem mirror using a fast-sweep hyperabrupt varactor-tuned oscillator (HTO) that can be swept over the full band (12–18 GHz) in less than 5 μs. Clear fringes are observed during a plasma shot when the resultant frequencies from the reflectometer output are much larger than the ion cyclotron range of frequency (3–10 MHz). The density profile measurement is performed for various sweep times of HTO from 1 ms to 5 μs in which two reconstruction methods are utilized, zero-cross counting of the fringes and frequency analysis using the maximum entropy method. The reliability of the profile measurement seems to be improved when the sweep time is faster than 10–30 μs. The integrated value of many reconstructed density profiles agrees well with the profile obtained from a scanning interferometer. The fast-sweep reflectometer is also applied to the measurement of density fluctuations such as plasma movement as well as density profiles. © 1997 American Institute of Physics.

Notes: The cross-polarization scattering (CPS) technique was applied to the GAMMA 10 tandem mirror for measurements of internal magnetic fluctuations associated with waves in the ion cyclotron range of frequency. The CPS is related to the mode-conversion effect consisting of a polarization difference of a scattered wave with regard to an incident wave. In GAMMA 10, the incident ordinary (extraordinary) wave is transferred to the extraordinary (ordinary) wave by magnetic field fluctuations near the cutoff layer of a plasma. The transferred wave penetrates through the cutoff layer and is detected. The frequency spectra and density and magnetic field fluctuations of the waves are evaluated from the CPS diagnostic and reflectometry. The ratio of the magnetic field to density fluctuation level depends on the phase velocity of the slow Alfvén wave. The CPS data are also compared with those obtained from magnetic probes. © 1997 American Institute of Physics.

Notes: A three-channel heterodyne O-mode reflectometer system has been developed for density fluctuation measurements on the JT-60U tokamak. The system consists of one fixed channel with a frequency of 34 GHz and two selectable frequency channels with frequencies in the range of 34–40 and 48–50 GHz in order to measure the change of fluctuation amplitude, fluctuation coherence, and movement of the cutoff layer during the discharge. The reflectometer system has now become a standard diagnostic for density fluctuation measurements on JT-60U covering both core and edge plasma regions. The capabilities of the system are illustrated for three experimental cases: edge transport barriers in H-mode plasmas, internal transport barriers in reversed shear plasmas, and fast turbulence burst at the onset of multifaceted asymmetric radiation from the edge. © 2002 American Institute of Physics.

Notes: A cross-polarization scattering (CPS) diagnostic method was applied to the GAMMA10 tandem mirror in order to study electromagnetic plasma waves with frequency less than 10 MHz. In the CPS process, an incident ordinary (extraordinary) wave is converted to an extraordinary (ordinary) wave by magnetic fluctuations in a plasma. The frequency spectra, and the density and magnetic fluctuations of the waves can be evaluated from both the CPS and reflectometry. The converted wave propagates through the cutoff layer and reaches a different diagnostic port with a receiver horn. The observed waves are identified as the electromagnetic drift wave assuming the wave number matching condition. The low frequency waves nonlinearly coupled with the Alfven ion cyclotron waves are also observed with increase in the plasma pressure. © 1999 American Institute of Physics.