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  • 1
    ISSN: 1432-0509
    Keywords: Angiography ; Endoscopy ; Gastrointestinal hemorrhage ; Telangiectasis ; Turner's syndrome ; Vermiform phlebectasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of congenital vascular bowel lesions in Turner's syndrome resulting in severe gastrointestinal bleeding is presented. The vascular malformations were verified by angiography. Pathogenesis, diagnosis, and treatment are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei insgesamt 120 Patienten wurden im Rahmen routinemäßiger gastroduodenoskopischer Untersuchungen Schleimhautbiopsien zur Kultivierung vonCampylobacter pyloridis entnommen. Bei sechs von sieben Patienten mit Ulcus ventriculi, 14 von 15 mit Ulcus duodeni, 15 von 20 mit Erosionen der Magenschleimhaut, 31 von 61 mit Gastritis und fünf von fünf mit Duodenitis konnteC. pyloridis isoliert werden. Hingegen war der Keimnachweis bei allen 12 Patienten mit histologisch unauffälliger Mukosa nicht möglich. Bei chronisch aktiver Gastritis ließ sichC. pyloridis signifikant häufiger als bei chronisch inaktiver Gastritis nachweisen (100 bzw. 50%). Diese Ergebnisse stützen die Hypothese vonMarshall undWarren, die besagt, daßC. pyloridis möglicherweise eine wichtige Rolle in der Entstehung von Gastritis und Ulcus pepticum zukommt.
    Notes: Summary During routine gastroduodenoscopic examination of 120 patients, biopsies of gastric mucosa were taken for the isolation ofCampylobacter pyloridis. The organism was isolated from six of seven patients with ulcus ventriculi, 14 of 15 with ulcus duodeni, 15 of 20 with erosions of the gastric mucosa, 31 of 61 with gastritis and five of five with duodenitis. In contrast, the cultures were negative in all of the 12 patients with histologically normal mucosa.C. pyloridis was isolated significantly more frequently from patients with active chronic gastritis than from those with inactive chronic gastritis (100% vs. 50%). These results support the suggestion ofMarshall andWarren that this bacterium may play an important role in the development of gastritis and peptic ulcer.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2568
    Keywords: Crohn's disease ; interferon-α ; interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several case reports suggested good effects of interferon-α in patients with Crohn's disease. In addition, a decreased production of interferon-α in Crohn's disease has been shownin vitro. Treatment with interferon-α may activate intestinal natural killer cells and down-regulate the overproduction of inflammatory cytokines like interleukin-6 in Crohn's disease. To evaluate the clinical efficacy of interferon-α, we treated 12 patients with a chronic active course of Crohn's disease with recombinant human interferon-α prospectively for 24 weeks. Prednisolone was continuously tapered and discontinued at week 12. The end point of the study was the prevention of worsening of clinical symptoms defined with the Crohn's disease activity index and was monitored by acute-phase proteins, interleukin-6 serum concentrations, and endoscopy. The biochemical activity of interferon-α was measured by 2′,5′-oligo adenylate serum levels. The end point of the study was reached in four patients (33%). In these patients the final Crohn's disease activity index was above 150, which means that they did not achieve clinical remission. All other patients (66%) did not respond to interferon-α and had to be withdrawn prematurely. Interferon-α did not show any beneficial effect on interleukin-6 or acute-phase protein concentrations and on endoscopic activity. The 2′,5′-oligo adenylate levels continuously increased during interferon therapy. Considerable side effects were noted. These results fail to demonstrate a therapeutic role of interferon-α in chronic active Crohn's disease.
    Type of Medium: Electronic Resource
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