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  • 1
    Electronic Resource
    Electronic Resource
    Sub-μm linewidth input coils for low Tc integrated thin-film dc superconducting quantum interference devices (1992)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 61 (1992), S. 336-338 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have, for the first time, demonstrated integrated dc superconducting quantum interference devices (SQUIDs) with input coils of linewidth down to 0.5 μm. The SQUID inductance L consists of a single octagonal washer or two or four such washers configured in parallel. The input coil of inductance Li, which couples to L with a mutual inductance of Mi, consists of fine-line octagonal spiral(s) fabricated in close proximity to the washer(s). For a two-washer SQUID with twin 80-turn, 0.5 μm spirals, Li=2.5 μH, Mi=12.7 nH, L=109 pH, and the coupling constant k2=0.85. This entire device occupies an area of less than 0.2 mm2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.107929
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  • 2
    Electronic Resource
    Electronic Resource
    Rates and pathways of vibrational self-relaxation of HF(v=2) between 300 and 700 K (1985)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 82 (1985), S. 780-788 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The temperature dependencies of the total self-relaxation rate constants for the vibrational deactivation of HF(v=2) and HF(v=1) and the state-to-state vibration-to-vibration (V–V) and vibration-to-translation-and-rotation (V-T,R) energy transfer components of the HF(v=2) self-relaxation process are measured using the overtone vibration excitation-laser double resonance technique. The total self-relaxation rate constants vary inversely with temperature. The much weaker temperature dependence of HF(v=2) self-relaxation compared to that of HF(v=1) arises from the significant role of the V–V energy transfer route. Competition between energetics and collision duration results in a weaker inverse variation with temperature for the slightly endothermic V–V route than for the exothermic V-T,R route for HF(v=2). The branching ratio for V–V energy transfer increases slightly with temperature and the data suggest that two quantum relaxation processes constitute no more than 10% of the total self-relaxation of HF(v=2). The available temperature dependence data on self-relaxation of HF(v=1–5) form a consistent picture in which the energetics of the V–V and V-T,R relaxation pathways control their relative contributions to the total energy transfer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.448503
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  • 3
    Electronic Resource
    Electronic Resource
    Selenium status in relation to reduced glutathione peroxidase activity in aspirin-sensitive asthma (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Selenium status and its relationship to lowered platelet glutathione peroxidase activity was investigated in 18 subjects with aspirin (ASA)-induced asthma and in asthmatic and non-asthmatic ASA-tolerant subjects. Mean serum selenium concentration in ASA-toleranl asthmatics (1.25 μm; 98.5 μg/1) was significantly higher than that in ASA-induced asthma subjects (1.14μm/l; 89.7μg/1) and than that in healthy controls (1.15 μm/1.91 μg/1). Although there was a correlation between serum selenium concentration and platelet glutathione peroxidase activity, enzyme activity was significantly lower in the ASA-induced asthma group compared to other groups even after correcting for selenium status. These results indicate that lowered platelet glutathione peroxidase activity in ASA-induced asthma is a product of both selenium availability and an unidentified syndrome-specific (possibly genetic) factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb00831.x
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  • 4
    Electronic Resource
    Electronic Resource
    Soluble and participate activators of complement and granulomatous pulmonary reactions (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to test the hypothesis that the histological changes of extrinsic allergic alveolitis result from non-specific activation of the complement cascade we studied pulmonary reactions to equivalent doses of soluble and particulate activators of complement in rats. A single intratracheal instillation of zymosan, a particulate activator of the complement system, produced a florid granulomatous pneumonitis which was maximal at 5 days. This granulomatous reaction did not appear to be associated with the development of hypersensitivity to zymosan. Complement depletion by cobra venom factor did not suppress the granulomatous reaction. Equivalent doses of soluble activators of complement failed to produce any inflammatory changes in the lung. Large doses of immune complex produced an acute, complement dependent, haemorrhagic alveolitis which was maximal at 8 hr and which resolved completely by 48 hr. We conclude that the late granulomatous pulmonary reaction to intra-tracheally administered zymosan is not due to an immune response, or a consequence of direct activation of the alternative pathway of complement, but is of ‘foreign body’ type. We urge caution in drawing conclusions regarding the pathogenesis of the allergic alveolitides on histological appearances alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1981.tb01574.x
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  • 5
    Electronic Resource
    Electronic Resource
    Activation of the alternative pathway of complement by grain (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 8 (1978), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ground whole rye and airborne rye dust of comparable size distribution were tested for their ability to activate the complement cascade via the alternative pathway. Precipitin-negative pooled normal human serum was incubated with increasing amounts of the two rye dusts. Electrophoresis of the resultant supernatant fluids demonstrated the conversion of the proactivator of the third component of complement to the gamma-migrating activator of the third component. This activation was completely prevented by pre-treating the serum with the chelator EDTA, while pre-treatment with EGTA allowed suboptimal arc conversion, strongly implying that complement was activated via the alternative pathway. Quantification of the supernatant fluids showed dose-dependent complement consumption as defined by both CH100 immunoditfusion and CH50 tube haemolytic techniques.Airborne rye dust showed a greater quantitative potential than ground whole rye for activating the alternative pathway. These results indicate the possibility of the direct action of airborne organic dusts on the induction of inflammatory sequelae in the lungs of both sensitized and unsensitized individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1978.tb00457.x
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  • 6
    Electronic Resource
    Electronic Resource
    Respiratory allergy and month of birth (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 7 (1977), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A total of 476 patients with respiratory allergy were interviewed to establish whether the season of birth influenced the type of allergy experienced. Patients with perennial symptoms did not differ from the general population of the U.K. in the distribution of their months of birth. Patients with summer seasonal symptoms attributable to grass pollen sensitivity were more likely to have been born in December to February than in August to November. This trend was most significant in female patients who did not have associated perennial symptoms and who developed symptoms early in life. Other significant differences were also noted between groups of patients complaining of the same symptoms. More males than females had summer seasonal symptoms whereas more females than males had perennial symptoms. Patients who had both perennial symptoms and summer seasonal exacerbations had a higher incidence of a positive family history of atopy and developed symptoms earlier in life than those patients who had summer seasonal or perennial symptoms only.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1977.tb01421.x
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  • 7
    Electronic Resource
    Electronic Resource
    Abnormal platelet hydrogen peroxide metabolism in aspirin hypersensitivity (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The generation and degradation of hydrogen peroxide (H2O2) by platelets was investigated in aspirin hypersensitive and tolerant allergic subjects, and compared to that in general medical patients and healthy controls. H2O2 generation following triggering with anti-IgE. specific allergen, and with aspirin (ASA) and indomethacin was examined using a chemiluminescence assay. Platelet levels of the main intracellular enzyme responsible for H2O2 metabolism–glutathione peroxidase–were measured by a quantitative functional assay. H2O2 secretion could be triggered by anti-IgE in platelets from 15/29 ASA-tolerant atopies, and by relevant allergen in platelets passively sensitized with allergen-specific IgE. A similar response was observed following triggering with ASA, and with indomethacin, in platelets from 8/25 ASA-sensitive subjects. Mean platelet glutathione peroxidase activity was significantly lower in subjects with ASA-induced asthma, but not in subjects with non-asthmatic reactions to ASA, compared to all other groups. Within the ASA-sensitive group there was no correlation between low peroxidase activity and ASA-triggered chemiluminescence. Our findings emphasize the heterogeneity of ASA-intolerance syndromes and point to abnormal oxygen/peroxide metabolism as a common pathway underlying ASA-induced asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02661.x
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical diagnosis in food allergy (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 19 (1989), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1989.tb02350.x
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  • 9
    Electronic Resource
    Electronic Resource
    Acetyl-carnitine in Heart and Liver (1964)
    [s.l.] : Nature Publishing Group
    Nature 202 (1964), S. 91-91 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Acetyl-carnitine has been assayed by combining reaction (1), catalysed by carnitine acetyl transferase, with an assay for acetyl-coenzyme A (reaction (2)). acetyl-carnitine + Co^4.-〉 acetyl-Co^4. + carnitine (1) acetyl-CoJ. + L-malate+NAD-〉 citrate + NAD.H2 + Co^4 (2) Reaction (2) is catalysed ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/202091a0
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