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  • 1
    Electronic Resource
    Electronic Resource
    Sequence of the penicillin-binding protein 2-encoding gene (penA) of Neisseria perflava/sicca
    Amsterdam : Elsevier
    Gene 146 (1994), S. 91-93 
    Details
    ISSN: 0378-1119
    Keywords: Commensal Neisseria ; antibiotic resistance ; homology ; membrane protein
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(94)90839-7
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Infratentorial ependymomas of childhood (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 208-216 
    Details
    ISSN: 1432-0533
    Keywords: Infratentorial ependymomas ; Childhood ; Immunohistochemistry ; AgNORs ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have examined pathological criteria in 16 cases of infratentorial ependymomas of childhood using a conventional histological approach, with immunohistochemistry and silver nucleolar organizer region staining (AgNORs). We have found that some of these criteria are of prognostic value. The following histological features were evaluated in each case: cellular density, cellular or nuclear pleiomorphism, mitosis, focal necrosis, endothelial proliferation and complete loss of differentiation. The expression of the following antigens was also studied: epithelial membrane antigen (EMA), human natural killer (HNK1), glial fibrillary acidic protein (GFAP) and vimentin. Only three histological criteria have been retained as indicative of bad prognosis, i.e., high mitotic index, a large amount of necrosis and complete loss of differentiation. These criteria distinguish ependymomas from anaplastic ependymomas. GFAP was expressed in all tumors while other antigens were more variable. In addition tumors expressing large amounts of GFAP were statistically associated with a better prognosis. Increased vimentin expression associated with a decrease of GFAP immunoreactivity correlated with anaplasia and short survival. EMA was not directly correlated with postoperative survival but may be considered as a further prognostic factor. Finally AgNORs values were not statistically correlated with postoperative survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294447
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence of glucagon biosynthesis involving protein intermediates in rat salivary glands (1984)
    Springer
    Diabetologia 27 (1984), S. 472-477 
    Details
    ISSN: 1432-0428
    Keywords: Glucagon biosynthesis ; protein intermediates ; rat submaxillary glands
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to determine the ability of rat submaxillary glands to synthesise glucagon via protein intermediates, isolated cells from these glands were incubated in vitro with 3H-L-tryptophan and the acid-ethanol extracts of the cells were purified on Bio-Gel P-30 columns. Aliquots of the eluates were incubated with a C-terminal glucagon antiserum (30K) and the radioactivity bound to the glucagon antibody appeared to be distributed among proteins of Molecular weight 〉40.14 and 3.5 Kdaltons. A similar elution pattern was obtained in the presence of urea (7 mol/l) and guanidine hydrochloride (6 mol/l). To determine the molecular weight of the immunoreactive material eluting before the 3.5 Kdalton polypeptide, aliquots of the cell extracts were immunoprecipitated and analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis. Polypeptides of 125.8, 63.1, 42.6 and 14.4 Kdaltons were obtained. These polypeptides incorporate more radioactive tryptophan with increase in the time of incubation. Pulse-chase experiments with unlabelled tryptophan, cycloheximide-treatment of isolated cells and limited tryptic digestion of the larger glucagon immunoreactive component, transform it into a 3.5 Kdalton polypeptide with immunological characteristics indistinguishable from pancreatic glucagon. These results suggest that the larger molecule contains glucagon and thus may serve as a precursor or an intermediate of extrapancreatic glucagon biosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273914
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    An r(22)(p11→q13) in a moderately mentally retarded girl (1979)
    Springer
    Human genetics 〈Berlin〉 51 (1979), S. 157-162 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An r(22) was detected in a 6-year-old female patient with growth retardation, IQ of 45, and a lower quotient for verbal performance. She presents some other minor anomalies. The break and fusion points probably were at p11 and q13.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00287170
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  • 5
    Electronic Resource
    Electronic Resource
    Infertility associated with two accessory bisatellited chromosomes (1986)
    Springer
    Human genetics 〈Berlin〉 73 (1986), S. 133-136 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two extra bisatellited chromosome identified as inv dup (15) (pter→q11.2::q11.2→pter) were found in an oligoasthenospermic male. Analysis of Ag-staining in the proband and in one fertile brother with a normal karyotype revealed that nucleolar organizer region (NOR) activity was significantly increased in the patient. The frequency of satellite associations was also significantly higher in the index case, but no correlation was found between NOR activity and acrocentric associations. These results suggest that extra NOR activity and the elevated frequency of satellite associations could predispose to gametogenic impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291603
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Trisomy 10p due to a de novo t(10p;13p) (1979)
    Springer
    Human genetics 〈Berlin〉 46 (1979), S. 129-134 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new case of trisomy 10p has been identified by means of the GTG-banding technique. The patient is a female child carrying a sporadic translocation, t(10;13)(p11;p11), and affected by microsomatia and microcephaly with facial dysmorphia, retarded growth, weight gain, and psychomotor development, and bilateral talipes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291912
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    New insights into the effects of extra nucleolus organizer regions (1986)
    Springer
    Human genetics 〈Berlin〉 72 (1986), S. 80-82 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chromosome studies were carried out in four members of a sibship with a 15p+chromosome. Two carriers had normal offspring, one was unmarried, and the index case had three abortions and no live children. By means of different banding techniques, up to four satellites and four stalks could be observed on the abnormal chromosome. The Ag-I method showed from zero to four silver precipitates on the 15p+marker. Mean Ag-staining for 15p+and the ten acrocentric chromosomes were obtained in the carriers. Statistically significant differences between sibs were found. These results suggest the existence of: (a) An interindividual and intercellular variation of nucleolus organizer region (NOR) activity in man. (b) An optimal threshold of NOR activity, so that disturbances at the meiotic level could occur when it is exceeded. Our conclusions lead us to advise analysis of NOR activity in individuals with extra nucleolus organizer regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278823
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