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  • 1
    Electronic Resource
    Electronic Resource
    Growth of Streptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits rapamycin production (2000)
    Springer
    Applied microbiology and biotechnology 54 (2000), S. 33-36 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Growth of Streptomyces hygroscopicus under conditions of simulated microgravity in a rotating-wall bioreactor resulted in a pellet form of growth, lowered dry cell weight, and inhibition of rapamycin production. With the addition of Teflon beads to the bioreactor, growth became much less pelleted, dry cell weight increased but rapamycin production was still markedly inhibited. Growth under simulated microgravity favored extracellular production of rapamycin, in contrast to a greater percentage of cell-bound rapamycin observed under normal gravity conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002539900303
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fungal colonization of fiberglass insulation in the air distribution system of a multi-story office building: VOC production and possible relationship to a sick building syndrome (1996)
    Springer
    Journal of industrial microbiology and biotechnology 16 (1996), S. 280-285 
    Details
    ISSN: 1476-5535
    Keywords: fungal colonization ; fiberglass insulation ; Penicillium spp ; Cladosporium spp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Complaints characteristic of those for sick building syndrome prompted mycological investigations of a modern multi-story office building on the Gulf coast in the Southeastern United States (Houston-Galveston area). The air handling units and fiberglass duct liner of the heating, ventilating and air conditioning system of the building, without a history of catastrophic or chronic water damage, demonstrated extensive colonization withPenicillium spp andCladosporium herbarum. Although dense fungal growth was observed on surfaces within the heating-cooling system, most air samples yielded fewer than 200 CFU m−3. Several volatile compounds found in the building air were released also from colonized fiberglass. Removal of colonized insulation from the floor receiving the majority of complaints of mouldy air and continuous operation of the units supplying this floor resulted in a reduction in the number of complaints.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570035
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Secondary metabolism in simulated microgravity: β-lactam production by Streptomyces clavuligerus (1997)
    Springer
    Journal of industrial microbiology and biotechnology 18 (1997), S. 22-25 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: simulated microgravity; gravity; β-lactam antibiotics; Streptomyces clavuligerus; space microbiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Rotating bioreactors designed at NASA’s Johnson Space Center were used to simulate a microgravity environment in which to study secondary metabolism. The system examined was β-lactam antibiotic production by Streptomyces clavuligerus. Both growth and β-lactam production occurred in simulated microgravity. Stimulatory effects of phosphate and L-lysine, previously detected in normal gravity, also occurred in simulated microgravity. The degree of β-lactam antibiotic production was markedly inhibited by simulated microgravity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900345
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Fungal colonization of synthetic substrates for use in space craft (1995)
    Springer
    Journal of industrial microbiology and biotechnology 14 (1995), S. 26-30 
    Details
    ISSN: 1476-5535
    Keywords: Fungal colonization ; Space craft materials ; Acremonium obclavatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Materials being used or considered for use in space flight were examined for their susceptibility to fungal colonization. The materials included soft goods (clothing) and insulation and fabrication products such as Velcro® attachments and elastic cord binders. Materials were exposed for at least 28 days in a highhumidity chamber colonized with over 50 species of fungi, including those species recommended for determining recalcitrance of materials to fungal biodegradation. At least nine of 25 products demonstrated extensive microscopic colonization by fungi, mostly byAcremonium obclavatum. Challenge procedures that rely on observations with the unaided eye, or 40×magnification of growth by a restricted number of fungal species with a cellulosic substrate as a positive control, are insufficient for determining the resistance of synthetic substrates to fungal colonization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570062
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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