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  • 1
    Electronic Resource
    Electronic Resource
    Plasma membrane-integrated estrogen receptors in breast tissue: Possible modulator molecules for intracellular hormone level (1981)
    Springer
    Journal of cancer research and clinical oncology 100 (1981), S. 135-148 
    Details
    ISSN: 1432-1335
    Keywords: Estrogen receptor ; Breast cancer tissue ; Plasma membrane ; fluorescence probe ; Antiestrogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma membrane fractions from tumor specimens of 14 peri-and postmenopausal primary breast cancer patients and from non-neoplastic tissues were prepared by sucrose density sedimentation The membranes were desintegrated by Triton X-100 and the 3H-estrogen binding capacity of membrane-derived proteins was determined. The receptor system found in the plasma membranes was mainly of low affinity and high capacity, working apparently in tandem with the high affinity and low capacity system described for the cytosol. Receptor concentrations in plasma membranes of non-neoplastic and neoplastic tissue were distributed over a wide range of values, but a significantly lowered receptor capacity was found in neoplastic tissue. An association constant, Ka=6.35·1010 M -1 was determined for neoplasma-derived membrane receptor proteins, whereas non-neoplastic tissue membrane proteins were not saturable, when incubated with up to 150 pmol 3H-estradiol. From a Scatchard plot analysis of some experiments a molar concentration of binding sites for membrane proteins, derived from breast cancer tissue, n(M)=1.7·10-12/mg protein was extrapolated. Furthermore, ample evidence was provided by an estrogen fluorescence probe that an estrogen binding system is located within the plasma membrane. It is suggested that the estrogen binding capacity of the epithelium cell membrane, due to the phospholipid moiety, can modulate the estrogen uptake and, thus, preventing hazardous high levels of estrogens within the cytoplasm. The presented experimental data throw a new light on the use of antiestrogens in the treatment of breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403363
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  • 2
    Electronic Resource
    Electronic Resource
    229. Neuer Fiberglasverband zur Ruhigstellung. Ergebnisse experimenteller und klinischer Erprobung von 595 Fiberglasverbänden (1973)
    Springer
    Langenbeck's archives of surgery 334 (1973), S. 987-987 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Material des Verbandes besteht aus Binden gängiger Breiten in Gitterform (5 x 5 mm), die mit Kunstharz und photosensiblem Härter imprägniert unter UV-Bestrahlung in 6 min polymerisieren. Die Anlage der Verbände erfolgt ähnlich der herkömmlichen Gipstechnik: Spalten, Fenstern und Keilen sind möglich. Die Röntgenaufnahmen in normaler Knochentechnik (geringe Strahlenbelastung) sind üblich beurteilbar. Die Hauptvorteile bestehen in einem 2/3 leichteren Gewicht, völliger Wasserunempfindlichkeit bei Luftdurchlässigkeit und sofortiger Belastbarkeit. Hierdurch ergibt sich eine leichtere Mobilisierung besonders älterer oder mehrfach verletzter Patienten, auch im Wasser, mit gleichzeitiger Möglichkeit der Körperpflege durch Duschen und Baden sowie Reinigung verschmutzter Verbände.
    Notes: Summary The materials used for the cast are open-weave fibre glass tapes in conventional sizes, impregnated with a photosensitive resin which becomes rigid after a six-minute exposure to ultraviolet light. The method for application of the fibre glass tape is similar to that used with plaster; windowing and wedging of the cast is possible. The main advantages are the weight, which is about two thirds the weight of plaster, the impermeability to water although air can pass through the east, and immediate weight bearing. This means easier mobilization, especially for elderly persons and patients with polytraumas, and at the same time, the possibility of maintaining personal hygiene by bathing and showering and cleaning of dirty bandages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01286762
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  • 3
    Electronic Resource
    Electronic Resource
    264. Beeinflussung der Knochenheilung durch Fibrin —Experimentelle Untersuchungen und klinische Perspektiven (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 628-628 
    Details
    ISSN: 1435-2451
    Keywords: Fibrin adhesion ; Fixation of corticocancellous bone fragments ; Cancellous-bone-fibrin plug ; Bone healing ; Fibrinklebersystem ; Fixierung corticospongiöser Fragmente ; Spongiosa-FibrinkleberPlombe ; Knochenheilung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Fixierung kleiner corticospongiöser Fragmente am Os ilium von Kaninchen mit dem Fibrinklebersystem (FKS) hatte eine gute intra- (100 p/cm2) und postoperative (8. d: 1300 p/cm2) Haftung und einen beschleunigten Einbau zur Folge. Bei Auffüllung ausgedehnter Knochendefekte (1 cm Segmentdefekt an der Tibia von Hunden) mit der Spongiosa-Fibrinkleber-Plombe (SFP, 3:1) konnte mikroangiographisch, scintigraphisch und mit intravitaler polychromer Fluorescenzmarkierung eine Beschleunigung von Revascularisation und Knochenstoffwechsel nachgewiesen werden. Klinisch hat sich das FKS zur hämostyptischen Tamponade von Spongiosaentnahmestellen (25), zur Fixierung abgesprengter Knochenfragmente und als SFP bei ausgedehnten Knochendefekten (41) bewährt.
    Notes: Summary Fixation of small corticocancellous bone fragments of rabbit ilium using fibrin glue revealed excellent adhesive power during the operation (100p/cm2) and post-operatively (day 8: 1,300p/cm2) and accelerated fracture healing. In order to improve repair of extensive bone defects, segmental tibia defects in dogs (extension 1 cm) were replaced using cancellous-bone-fibrin plugs (CBFP, 3:1). Microangiographical studies, uptake of99m'Tc-MDP and polychrome sequential labelling of new bone formation indicated acceleration of vascular sprouting and rapid osseous bridging. Our clinical experience comprises the application of fibrin adhesion for haemostatic tamponade of bone cavities (25), for fixation of bone fragments, and for refilling skeletal defects, used as CBFP (41).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287097
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  • 4
    Electronic Resource
    Electronic Resource
    170. Klinische Erfahrungen mit Fibrinkleber in der Unfallchirurgie (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 530-530 
    Details
    ISSN: 1435-2451
    Keywords: Fibrin-adhesive ; Collagen sponge ; Bone-fragments ; Cancellous bone graft ; Fibrinklebung ; Kollagenvlies ; Knochenfragmente ; Spongiosaplastik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach umfangreichen tierexperimentellen Studien, die eine günstige Beeinflussung der Knochenheilung durch hochkonzentriertes Fibrin zeigten, wurden Fibrinklebungen bei ausgewählten Fällen in der Knochenchirurgie durchgeführt. - Das Klebeverfahren kam zunächst in Verbindung mit Kollagenvlies zur Anwendung, um Spongiosaentnahmestellen wieder aufzufüllen. Später wurden mit einem Fibrinkleber-Spongiosa-Gemisch auch frische oder ältere Defektbereiche überbrückt und kleinere knöcherne oder osteocartilaginäre Fragmente fixiert. Zusammenfassend gesehen zeigte die Fibrinklebung bei Spongiosaplastiken und bei der Fixierung kleiner Fragmente einen positiven Effekt und ist daher zur weiteren Anwendung in der Unfallchirurgie geeignet.
    Notes: Summary Application of the fibrin-adhesive technique in traumatology was studied in animals. According to the excellent results, this technique was used in some selected cases in man. Bleeding cancellous bone defects were treated with fibrin-adhesive in combination with resorbable collagen sponges. Treatment of fresh or old bone defects was performed by cancellous bonefibrin adhesive mixtures. This method was even useful in fixation of small bone as well as cartilage fragments. Follow-up studies revealed that fibrin promotes bone healing and remodeling, which indicates the potential use of the fibrin adhesive technique in traumatology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292133
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