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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Eukaryotic initiation factor 2B, or guanine nucleotide-exchange factor, has been purified for the first time from the brain by a novel procedure that allows the purification of initiation factor 2 as well and uses a salt wash postmicrosomal supernatant as starting material. The procedure includes a three-part chromatographic step in heparin-Sepharose and in SP-5PW and diethylaminoethyl-5PW ion-exchange high-performance chromatographies. The purification of the factors was followed by measuring activity in the guanine nucleotide-exchange assay and the capacity of initiation factor 2 to form a ternary complex with the initiation form of methionyl-tRNA and GTP. The method yields guanine nucleotide-exchange factor (75%) and highly purified initiation factor 2 (〉95%), which are separated in the last step. The exchange factor from the brain is a multimeric protein with five subunits of molecular masses of 82, 65, 52, 42, and 30 kDa; it stimulates ternary complex formation in the presence of GDP, and this activity is inhibited by N-ethylmaleimide. A 37-kDa protein that copurifies with initiation factors is characterized in this study as a new calmodulin-binding protein (p37); it is highly phosphorylated by casein kinase activities and can comigrate with the α subunit of initiation factor 2 under standard sodium dodecyl sulfate electrophoresis conditions.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 6269-6275 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Inversion-layer mobility has been investigated in extremely thin silicon-on-insulator metal–oxide–semiconductor field-effect transistors with a silicon film thickness as low as 5 nm. The Poisson and Schrœdinger equations have been self-consistently solved to take into account inversion layer quantization. To evaluate the electron mobility, the Boltzmann transport equation has been solved by the Monte Carlo method, simultaneously taking into account phonon, surface-roughness, and Coulomb scattering. We show that the reduction of the silicon layer has several effects on the electron mobility: (i) a greater confinement of the electrons in the thin silicon film, which implies an increase in the phonon-scattering rate and therefore a mobility decrease; (ii) a reduction in the conduction effective mass and the intervalley-scattering rate due to the redistribution of carriers in the two subband ladders as a consequence of size quantization resulting in a mobility increase; and (iii) an increase in Coulomb scattering because of a greater number of interface traps in the buried Si–SiO2 and to a closer approach of these charged centers to the mobile carriers. The dependence of these effects on the silicon-layer thickness and on the inversion-charge concentration causes the mobility to be a nontrivial function of these variables. A detailed explanation of the mobility behavior is provided. Mobility for samples with silicon thickness below 10 nm is shown to increase in an electric field range that depends on the charged center concentration, while for silicon layers over 10 nm mobility always decreases as the silicon-layer thickness is reduced. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 4221-4232 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this paper we study the low-lying energy levels of Co2+ and Fe2+ in diluted magnetic semiconductors, such as Cd1−xCoxTe and Cd1−xCoxSe, and their iron-based counterparts. In the first of these compounds, the magnetic ion sits on a site of symmetry Td, while in the second the symmetry is trigonal (C3v). We develop a formulation that permits a continuous variation from Td to C3v symmetry. Comparison with experimental data in Cd1−xCoxSe shows that the C3v distortion amounts to about 10% of the crystal potential at the Co2+ site. Our study of the energy spectra of Fe2+ in Td and C3v crystal potentials reveals that, even in the cubic field, the levels exhibit an anisotropy which manifests itself in an anisotropy of the magnetization M in the regime in which M is not a linear function of the magnetic field B. The study includes all the levels in the lowest terms of the (3d)7 and (3d)6 configurations of Co2+ and Fe2+, thus considerably extending work by previous authors. The calculations are carried out to second order in the spin-orbit interaction and in B for the lowest orbital states, and to first order in B for the excited states. The g factors of all the levels are obtained including their anisotropy for the Co2+ Γ8 states.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 447-449 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present an analysis of the long-wavelength spin-wave excitations in superlattices of diluted magnetic semiconductors. The different magnetic modes are classified as "pure-bulk,'' "pure-interface,'' and "bulk-interface'' depending on whether they propagate along the axis of the superlattice in the two components of the structure, they decay in both regions, or they propagate in one and decay in the other. Numerical applications are considered related to inelastic light scattering from superlattices of Cd1−xMnxTe.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 3592-3594 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This letter describes the monolithic integration of rubber-stamped thin-film organic transistors with polymer-dispersed liquid crystals (PDLCs) to create a multipixel, flexible display with plastic substrates. We report the electro-optic switching behavior of the PDLCs as driven by the organic transistors, and we show that our displays operate robustly under flexing and have a contrast comparable to that of newsprint. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study examined the dose–response effects of the new proton-pump inhibitor rabeprazole on oesophageal and gastric pH in patients with gastro-oesophageal reflux disease.〈section xml:id="abs1-2"〉〈title type="main"〉MethodsThis study had a single-centre, double-blind, randomized, two-way crossover design. Twenty patients were treated for two 7-day periods separated by a 7–10-day washout period. Patients were randomly assigned to receive either 20 mg of rabeprazole once daily during the first treatment period and 40 mg once daily during the second treatment period, or 40 mg during the first treatment period and 20 mg during the second treatment period. The primary efficacy variable was oesophageal acid exposure determined by 24-hour ambulatory pH monitoring. Acid-reflux time was defined as the percentage of time over 24 h that oesophageal pH was 〈4. A dosage was considered effective if reflux time was reduced to 〈6%, a number which has been our internal laboratory reference.〈section xml:id="abs1-3"〉〈title type="main"〉ResultsBoth rabeprazole 20 mg and 40 mg, given once daily, normalized reflux time, with decreases of 79% and 92% in acid exposure by day 7. Both dosages also decreased the mean total number of reflux episodes and the number of episodes lasting〉 5 min, with no significant differences between dosages for any reflux parameter. Mean gastric pH increased with 20 mg from 1.86 at baseline to 3.71 on day 1 and 4.17 on day 7. Rabeprazole 40 mg once daily increased gastric pH from 2.01 to 4.37 on day 1, and to 4.65 on day 7. Safety analyses revealed no significant acute side-effects for either dosage.〈section xml:id="abs1-4"〉〈title type="main"〉ConclusionsPathological oesophageal acid exposure was normalized with both 20 mg and 40 mg dosages of rabeprazole, and the effects of these two doses did not differ. Rabeprazole was well-tolerated in this short-term study.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 68 (2003), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Biogenic amines and polyamines were measured in unripened cheese and 4 types of ripened cheese. The study included cheeses produced from both pasteurized and raw milks. All amines were lower in unripened than in ripened cheeses. The amine contents varied among different types of ripened cheese, within the same type of cheese, and also within the parts of cheeses. The main amines in ripened cheeses were tyramine, cadaverine, and putrescine. The highest concentration of tyramine was found in hard-ripened raw-milk cheeses, while blue cheese had the highest level of cadaverine. Unripened cheeses could be considered as well-tolerated products for histamine- and tyramine-sensitive individuals, whereas the wide variability in biogenic amines makes it difficult to generalize this consideration for all ripened cheeses.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 7201-7207 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0304-4017
    Keywords: Dof ; Immune response-Protozoa ; Leishmania sp.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0304-4017
    Keywords: Cattle-Arthropoda ; Diagnosis-Arthropoda ; Hypoderma lineatum
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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