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  • 1
    Electronic Resource
    Electronic Resource
    Kinetics of brain glutamate decarboxylase. Dead-end and product inhibition studies (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10509.x
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  • 2
    Electronic Resource
    Electronic Resource
    043.08
PRISM ADAPTATION IN NORMALS: A POSSIBLE SIMULATION OF UNILATERAL-NEGLECT? (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00278-5.x
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  • 3
    Electronic Resource
    Electronic Resource
    Beziehungen zwischen zellständigen Lipiden und Dinatrium cromoglicicum (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 817-818 
    Details
    ISSN: 1432-1440
    Keywords: Disodium cromoglycate ; Cellular lipids ; Fluorescence microscopy ; Dinatrium cromoglicicum ; Zellständige Fluoreszenzmikroskopie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Dinatrium cromoglicicum (DNCG) geht Verbindungen mit zellständigen Lipiden ein. Nach Fixierung von Blut-Lymphozytenkultur-und Knochenmarkausstrichen mit DNCG und nachfolgender Färbung mit Pseudoisocyanin kommt es zur Grünfluoreszenz von Lipiden, die nach Methanol-Fixierung naturgemäß ausbleibt. Es wird diskutiert, daß der Angriffspunkt des Asthmaprophylaktikums DNCG Zellmembranlipide sind. DNCG-Lipidverbindungen könnten letzlich die IgE vermittelnden Reaktionen, die zur Degranulierung von Mastzellen führen, verhindern. Mastzellen, die einer Antigen-Antikörperreaktion ausgesetzt sind, sollen bei Einwirkung von Dinatrium cromoglicum (DNCG) nicht degranulieren. Dadurch wird die Freisetzung von Substanzen, die den Asthmaanfall auslösen, verhindert [5]. Über die Ursache dieser Degranulierungshemmung ist noch wenig bekannt. Im folgenden wird gezeigt, daß enge Beziehungen zwischen zellständigen Lipiden und DNCG bestehen.
    Notes: Summary Disodium cromoglycate binds in vitro and in vivo to lipids in white cells. Smears of cells from lymphocyte cultures and from bone marrow aspirates treated with DNCG and subsequently stained with pseudoisocyanine show a characteristic green fluorescence (515 nm) of membrane- and intracellular-lipids. It is suggested that the mode of action of DNCG in the prophylaxis of bronchial asthma could be the binding of DNCG to membrane lipids. This binding might block the IgE-mediated reaction on the surface of mast cells which otherwise would lead to degranulation and release of vasoactive substances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01651271
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  • 4
    Electronic Resource
    Electronic Resource
    Fluoreszenzmikroskopischer Nachweis saurer Mucopolysaccharide in menschlichen Blut- und Knochenmarkzellen (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 289-290 
    Details
    ISSN: 1432-1440
    Keywords: Fluorescence microscopy ; 9-Aminoacridin-hydrochloride ; Pseudoisocyanine ; Acid mucopolysaccharides ; Proerythroblast ; Fluoreszenzmikroskopie ; 9-Aminoacridin-hydrochlorid ; Pseudoisocyanin saure Mucopolysaccharide ; Proerythrocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Lymphocyten und Monocyten von Patienten mit Mucopolysaccharidosen sowie in basophilen Granulocyten kommt es zu einer spezifischen Fluoreszenz saurer Mucopolysaccharide nach Fixieren der Blutausstriche mit 9-Amoniacridinhydrochlorid und nachfolgender Färbung mit auf pH 4,2 gepufferten Pseudoisocyanin. Insgesamt wurden 11 Kinder mit verschiedenen Mucopolysaccharidose-Typen untersucht, wobei sich in 5 bis 49% aller rundkernigen Blutzellen spezifische Granula nachweisen ließen. Erstmals wurde auch der Nachweis von sauren Mucopolysacchariden in Erythrocyten-Vorstufen im Knochenmark von an Mucopolysaccharidose erkrankten Kindern erbracht.
    Notes: Summary In lymphocytes, monocytes and basophil granulocytes of patients with mucopolysaccharidosis specific fluorescence of acid mucopolysaccharides exists after fixation of blood smears with 9-aminoacridin-hydrochloride and subsequent staining with pseudoisocyanine at pH 4.2. A total of eleven children with various types of mucopolysaccharidosis were investigated. Specificaly stained granula were demonstrated in 5 to 49 percent of all lymphocytes and monocytes. Acid mucopolysaccharides were for the first time also shown in red-cell precursors of the bone marrow of children with mucopolysaccharidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468926
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  • 5
    Electronic Resource
    Electronic Resource
    Veränderungen des Endometriums postmenopausaler Patientinnen unter Tamoxifen (1993)
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 1215-1219 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Anhand von Verlaufsbeobachtungen über z.T. mehrere Jahre wird die Wirkung des Antiöstrogens Tamoxifen auf die Sonomorphologie und Sonobiometrie des Endometriums analysiert. Durch das erhöhte Risiko für Tamoxifen-Patientinnen, ein Endometriumkarzinom zu entwickeln, ergibt sich die klinische Relevanz dieser Untersuchungen. Medianwertverläufe und Vertrauensbereiche zeigen die sich bereits in den ersten 3 – 6 Monaten der Therapie ergebenden, z.T. erheblichen Veränderungen am Endometrium. Fallbeispiele erläutern darüberhinaus das praktische Procedere in den sich ergebenden Problemsituationen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02266371
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  • 6
    Electronic Resource
    Electronic Resource
    O6-methylguanine repair in liver cells in vivo: Comparison between G1- and S-phase of the cell cycle (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 36-45 
    Details
    ISSN: 1432-1335
    Keywords: Liver cells ; Cell cycle ; DNA alkylation ; O6-Methylguanine repair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To compare the formation and persistance of alkylated DNA bases in the G1- and S-phase compartments in liver in vivo, regnerating rat liver was exposed to [14C]dimethylnitrosamine (0.57 mg/kg, IP injection) or N-[methyl 14C]-N-nitrosourea (3.3 mg/kg, intraportal injection) during the G1 phase of the cell cyle (12 h after partial hepatectomy), or at 24 h after partial hepatectomy with 30% hepatocytes in DNA synthesis, or at 43 h after partial hepatectomy, 4 h after an hydroxyurea block from 14 to 39 h after operation with 80% hepatocytes in DNA synthesis. At 120 min after dimethylnitrosamine and 90 s, 5, 10, or 60 min after the intraportal pulse of N-methyl-N-nitrosourea the molar fractions of 7-methylguanine (7megua), O6-methylguanine (O6megua), and 3-methyladenine (3mead) and of metabolically labeled guanine were determined from DNA hydrolysates by Sephadex-G10 radiochromatography. After dimethylnitrosamine only minor differences were observed for 7megua formation in the three groups; the 3mead/7megua ratio remained constant irrespective of the number of cells in S phase. In contrast, the O6megua/7megua ratio revealed a loss of O6megua, the extent of which appeared proportional to the fraction of DNA-synthesizing cells in the liver. The rapid loss of O6megua in S-phase cells was confirmed after intraportal administration of N-methyl-N-nitrosourea. During the first 10 min after the methylnitrosourea pulse the O6megua/7megua ratio was constant in G1 cells and dropped from 90 s to 10 min by about 15% in liver containing 30% S-phase cells and by about 40% with 80% cells in DNA synthesis. DNA-synthesizing hepatocytes are apparently endowed with a higher O6megua DNA transferase activity than nonproliferating liver cells. The rapid, though exhaustible elimination of O6megua during S-phase might result in partial protection of DNA-synthesizing cells from base-mispairing and/or from hypomethylation at G-C sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390971
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  • 7
    Electronic Resource
    Electronic Resource
    O6-Methylguanine repair of methylated DNA in vitro: Cell cycle-dependence of rat liver methyltransferase activity (1985)
    Springer
    Journal of cancer research and clinical oncology 110 (1985), S. 98-102 
    Details
    ISSN: 1432-1335
    Keywords: Regenerating liver ; Cell cycle ; O6-Methylguanine DNA transferase ; DNA alkylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary O6-Methylguanine DNA transferase activity was investigated in liver proteins obtained at various intervals after partial hepatectomy and/or after hydroxyurea-induced synchronization of the liver cell cycle. Liver proteins were incubated with 3H-methylated calf thymus DNA as previously described by Pegg et al. (1981). The loss of O6-methylguanine was measured by radiochromatography of DNA hydrolysates. The extent of O6-methylguanine repair differed during the cell cycle: the activity increased in late G1, reached a maximum in early S phase and declined in late S phase and G2M. These results indicate that hepatocytes are endowed with an increased DNA repair capacity for this promutagenic lesion during the period of highest transformation sensitivity in the cell cycle. Though increased, however, this repair potential does not, because of its exhaustibility, appear to be sufficient to prevent initiation of transformation after high doses of alkylating carcinogens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402719
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  • 8
    Electronic Resource
    Electronic Resource
    Intramolecular interaction in aryldihydrothiophene 1,1-dioxides (1977)
    Springer
    Chemistry of heterocyclic compounds 13 (1977), S. 848-851 
    Details
    ISSN: 1573-8353
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The peculiarities of the intramolecular interaction in unsaturated five-membered cyclic sulfones as a function of their structures were studied on the basis of an analysis of the electronic absorption spectra of single crystals of isomeric β-aryldihydrothiophene 1,1-dioxides at 4.2°K, the IR spectra of the molecules at 298°K, and the results of x-ray diffraction analysis of 3-phenyl-4,5-dihydrothiophene 1,1-dioxide. In addition to the inductive effect, conjugation of the SO2 group with the π-electron system of 3-phenyl-4,5-dihydrothiophene 1,1-dioxide, which is manifested most appreciably in the excited electronic state, was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00488906
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  • 9
    Electronic Resource
    Electronic Resource
    Crystal and molecular structure of 1,1-bis(trimethylstannyl)cyclopentadiene (1975)
    Springer
    Journal of structural chemistry 16 (1975), S. 227-230 
    Details
    ISSN: 1573-8779
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00747137
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  • 10
    Electronic Resource
    Electronic Resource
    Crystal and molecular structure of 3-phenyl-3-thiolene-1,1-dioxide (1985)
    Springer
    Journal of structural chemistry 25 (1985), S. 663-664 
    Details
    ISSN: 1573-8779
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00747264
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