Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
41 (1995), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The expression of lymphokine genes during infection of virulent (Tulahuén) or mild (CA-I) strains of T. cruzi was studied in mice lacking CD4 and/or CD8 molecules. The increased susceptibility of CD4− and CD4−CD8− mice to infection with CA-I or Tuiahuen was parallelled by diminished IFN-γmRNA levels. Nitric oxide release and inducible nitric oxide synthase mRNA accumulation by cells from Tulahuen infected CD4− mice was also diminished. CD8− (but not CD4−CD8− mice) showed an increased IL-4 and IL-10mRNA accumulation upon infection with both strains of T. cruzi. A Th2-like’ response (higher IL-4 and IL-10mRNA to IFN-γmRNA ratio), was also observed when cells from non-infected CD8- mice were stimulated with T cell mitogens.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1995.tb03549.x
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