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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 2 (1978), S. 826-828 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Regional left ventricular function ; Aortocoronary bypass surgery ; Regionale linksventrikuläre Funktion ; Aorto-koronarer Bypass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 20 konsekutiven Patienten (mittleres Alter 51,6 Jahre) mit der Diagnose einer stabilen, schweren Angina pectoris wurden aortocoronare Bypass-Operationen durchgeführt und insgesamt 60 Anastomosen gefertigt. First-pass Radionuclid Ventrikulogramme (18–24 mCi 99m Technetium Pertechnetat i.v.) erfolgten sowohl in Ruhe als auch nach maximaler Belastung im Durchschnitt 9,4±1,5 Monate postoperativ. Neben der globalen Ejektionsfraktion (GEF) wurde die regionale Ejektionsfraktion (REF) gemessen. Die REF wurde neu definiert und mit einer speziellen Technik erarbeitet: Jedes postoperative Radionuklid-Ventrikulogramm (RAO-Ansicht) wurde in drei Regionen unterteilt, entsprechend dem Versorgungsgebiet der drei Hauptkoronararterien und ihrer Äste. Die Größe und die Verzweigung der Koronararterien wurden auf dem präoperativen Kontrastmittel-Koronarangiogramm eingesehen. Die GEF verbesserte sich nach maximaler Belastung in 13 Fällen um 8,1%-Einheiten (von 50,5 auf 58,5%), blieb unverändert 3mal und verschlechterte sich 4mal um 7,1%-Einheiten (von 51,6 auf 44,5%; alle Änderungenp〈0,05). In komplett revaskularisierten Regionen (n=33) verbesserte sich die REF 24mal um 9,7%-Einheiten (von 51,1 auf 60,8%). Die Belastungs-REF änderte sich nicht wesentlich von der Ruhe-REF 6mal; in drei Fällen konnte eine Verschlechterung um 7,3%-Einheiten gemessen werden (von 48,6 auf 41,3%; alle Veränderungenp〈0,05). Komplett revaskularisierte Regionen reagierten auf Belastung wie normal perfundierte Gebiete (Anstieg um 7,8%-Einheiten; von 50,6 auf 58,4%n=7;p〈0.05). Die REF verschlechterte sich in inkomplett revaskularisierten Gebieten (n=9) 6mal um 12,8%-Einheiten (von 58,0 auf 45,2%), blieb unverändert 2mal und verbesserte sich 1mal um 4.5%-Einheiten. Die REF der Gesamtgruppe verschlechterte sich um 7,3%-Einheiten (von 56,8 auf 49,5%;p〈0,05). Die Belastungs-REF der inkomplett revaskularisierten Regionen war hoch signifikant schlechter als diejenigen der komplett revaskularisierten Regionen (49,5 gegenüber 58,4%;p〈0,01). Die GEF ist eine gewichtete Bilanz aller dreier Ejektionsfraktionen. Der wichtigste Parameter ist die REF des Ramus interventricularis anterior-Gebietes.
    Notes: Summary Twenty consecutive patients (mean age 51.6 years) with persistent severe angina pectoris underwent aorto-coronary bypass surgery receiving an overall of 60 anastomosis. On an average, 9.4±1.5 months p.o. first pass radionuclide ventriculograms (18 to 24 mCi 99 m Technetium-Pertechnetate i.v.) were performed at rest and after excerise. Besides measurement of global ejection fraction (GEF), regional ejection fraction (REF) was assessed employing for the first time a new technique: each RAO-view of p.o. radionuclide left ventriculogram was subdivided into three regions according to supply of the three main coronary arteries and their branches as visualized on pre-operative coronary angiogram. GEF improved after maximum exercise in 13 cases by 8.1% points (from 50.4 to 58.5%), remained unchanged three times and decreased four times by 7.1 points (from 51.6 to 44.5%; all changesp〈0.05). In completely revascularized regions (n=35) REF improved 24 times by 9.7 points (from 51.1 to 60.8%), did not differ from rest REF six times and decreased in three case by 7.3 points (from 48.6 to 41.3%; all changesp〈0.05). Completely revascularized regions responded to exercise like normally perfused areas (increase 7.8 points (from 50.6 to 58.4%;n=7;p〈0.05). REF deteriorated in incompletely revascularized regions (n=9) six times by 12.8 points (from 58.0 to 45.2%), remained unchanged twice and improved once by 4.5 points. Total group's REF decreased by 7.3 points (from 56.8 to 49.5%;p〈0.05). Exercise REF of incompletely revascularized regions was highly significant inferior to that of completely revascularized regions (49.5 to 58.4%;p〈0.01). GEF is a weighted balance of the three regional ejection fractions. The most important parameter is REF of LAD territory.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-0743
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-0743
    Keywords: coronary artery disease ; first pass radionuclide angiography ; isonitriles ; single photon emission computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 99mTc-labeled methoxy-isobutyl-isonitrile (MIBI) allows a simultaneous radionuclide assessment of regional heart function and perfusion. In this study the effectiveness of functional and perfusional images obtained with99mTc-MIBI in the detection of coronary stenoses was compared with that of their combination. We studied 197 patients who underwent coronary angiography and a single-day radionuclide protocol including first pass angiography (multicrystal gamma camera) and single photon emission computed tomography, by means of 2 injections of99mTc-MIBI at rest and at peak exercise. Fifteen patients had 〈 50% stenoses, 50 had 1-vessel, 69 2-vessel and 63 3-vessel disease, for a total of 377 pathological major coronary vessels; 129 patients had previous myocardial infarction. Functional images, perfusional tomograms and their combination showed the same sensitivity (98%) and specificity (80%) in detecting coronary patients. Regional sensitivity and specificity of the combined analysis achieved 87% and 82%, respectively, vs. 94% (p 〈0.005) and 60% (p 〈0.001) of functional images, and 88% (p=N.S.) and 74% (p 〈0.05) of perfusional tomograms. Thus, the combined analysis of regional functional and perfusional abnormalities increased significantly the specificity in the detection of coronary stenoses, in comparison with the separate evaluation of function and perfusion, achieving also a slightly higher diagnostic accuracy (85%, vs. 81% and 83%, respectively). The results confirm that a single-day protocol simultaneously assessing regional myocardial function and perfusion with99mTc-MIBI represents a rapid and effective diagnostic method, that allows the physician to assess the presence and functional importance of coronary stenoses in less than 4 hours.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1619-7089
    Keywords: IPPA ; Fatty acid metabolism ; Coronary artery disease ; Cardiomyopathy ; Hypertensive disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 50 patients, 1 mCi123I phenylpentadecanoic acid (IPPA) was injected at peak ergometric stress and 1500 frames were acquired (1 frame/s) with a high count rate gamma camera. Parametric images of rates of decrease and increase for different time intervals after stress were compared with coronary angiography and LV ventriculography, separately evaluating the 3 main coronary territories: 18/150 territories supplied by normal coronaries presented rather homogeneous regional clearing rates, whereas a gradual decrease in clearing rates towards the end of the territory (frequently with peripheral defects) was seen in all 87/150 territories with significant coronary narrowing. In local correspondence to clearing defects, initial IPPA accumulations could be observed with later onset of clearing between 10 and 25 min. 44/150 territories presented abnormal clearing rates, mostly with a patchy pattern, with normal coronary anatomy, but all except one had LV dysfunction and a clinical diagnosis of Cadomyopathy, diabetes mellitus or hypertensive disease. Twenty four of the 41 patients with CAD had, in correspondence to a prior myocardial infarction, minimum or missing metabolic activity frequently in circumscribed zones, partly separated by bridges of still viable tissue with preserved but reduced clearing rates.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 8 (1983), S. 431-435 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The use of the short-lived (30 s) isotope 195mAu in brain perfusion studies has been tested on 40 patients and 8 volunteers. The activity of the eluate from the 195mHg/195Au generator was high enough to give good image statistics of brain perfusion after a single bolus injection. The examinations can be repeated after 3 min giving the same quality and without significant background. The use of a low-energy photon peak at 68 keV (Au−Kα) allows the imaging of brain perfusion in both lateral views with almost no look-through effect. With a modified height-over-area formula for the calculation of regional cerebral blood flow parametric images were obtained of high diagnostic value. The sensitivity and reproducibility, of the method has been demonstrated by mental stimulation tests on eight volunteers: after optical stimulation a clear increase of blood flow could be shown in the visual cortex.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 5 (1980), S. 229-235 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A general method for computation of regional blood flow from time-activity curves obtained after intravenous injection of 99m-Tc-pertechnetate is presented. The method is based on the well-known principle of Meier and Zierler, but, it also considers the dispersion of an intravenously injected activitybolus as well as the recirculation of the nondiffusible tracer. The problems arising from the use of a nondiffusible indicator concerning the partition coefficient lambda are discussed. This method of blood flow determination is adopted for measurements of cerebral blood flow and some first results are discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 471-472 
    ISSN: 1435-2451
    Keywords: Aortocoronary bypass ; Impaired left ventricular function ; Diffuse vessel disease ; Aortocoronarer Bypass ; Schlechte Ventrikelfunktion ; Diffuse Coronarsklerose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Patienten mit einer prdoperativen Ejektionsfraktion (EF) unter 40% weisen eine erhöhte Frühletalität auf (7,3% gegenüber 1,7%); die 5-Jahres-überlebenschance (Actuarial-Methode) bei präop. EF unter 30% betrugt 55% - bei präop. EF zwischen 31 % und 40% betragt sie 85%. Die komplette Revascularisation ist bei Patienten mit diffuser Coronarsklerose am wichtigsten. Unsere 19 mit der Herzbinnenraumszintigraphie nachuntersuchten Patienten erhielten im Schnitt 5,3 Anastomosen, wichtigstes Revascularisationsgebiet ist die RIVA-Region.
    Notes: Summary Patients with preoperative ejection fractions (EF) below 40% show increased early mortality (7.3% versus 1.7%). Whenever the preoperative EF was below 30%, the 5-year survival rate (actuarial method) measured 55%; in patients with a preoperative EF between 31% and 40%, the survival rate was 85%. For patients with diffuse coronary artery disease complete revascularization is most important. Of the 19 patients we reexamined, using a radionuclide technique, there was a mean 5.3 anastomosis; complete revascularization of the LAD region is the most important.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-2451
    Keywords: Coronary artery bypass grafting ; Regional ejection fraction ; First pass radionuclide angiography ; Aortocoronare Bypass-Operation ; Regionale Myokardfunktion ; First-Pass-Radionuklidangiographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 50 operierte und 50 durch Matching zugeordnete nichtoperierte Patienten mit einer coronaren MehrgefäBerkrankung wurden nach einem Beobachtungszeitraum von vier Jahren mit der First Pass-Radionuklidangiographie nachuntersucht. Nach Revascularisation fanden sich signifikant höhere Werte für die regionale Ejektionsfraktion unter Belastung und in stenosierten Territorien mit bereits abgelaufenem Infarkt. Die Ergebnisse unterstreichen die hämodynamischen Verbesserungen durch die aortocoronare Bypass-Operation, wobei Regionen mit schlechter Ruhefunktion besonders von der Revascularisation profitierten.
    Notes: Summary 50 patients after coronary artery bypass grafting were matched with 50 not-operated patients. After a follow-up period of four years they were investigated by first pass radionuclide angiography. Revascularized myocardial areas showed significantly higher regional ejection fraction during exercise and in territories with prior myocardial infarction. The results proved the hemodynamic benefits of coronary artery bypass grafting even in territories with poor myocardial function.
    Type of Medium: Electronic Resource
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