ISSN:
1432-1440
Schlagwort(e):
Parathyroid hormone
;
Vitamin D
;
25-hydroxyvitamin D
;
1,25-Dihydroxyvitamin D
;
Geriatric patients
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary In 50 patients of a geriatric hospital (33 women, aged 65–96 years, mean age 80 years, and 17 men, aged 68–91, mean age 78.3 years) calcium, albumin, phosphate, urea, creatinine, parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D were determined. Forty patients with serum creatinine levels up to 1.4 mg/dl (124 Μmol/l) and 10 patients with creatinine concentrations ≥1.5 mg/dl (132Μmol/l) were evaluated. In patients with normal creatinine, a positive correlation was found between parathyroid hormone and age (r=0.41;P〈0.01). In patients with elevated creatinine, negative correlations were found in 1,25-dihydroxyvitamin D and calcium (r=−0.724;P〈0.05), 1,25dihydroxyvitamin D and creatinine (r=−0.79;P〈0.01) and 1,25-dihydroxyvitamin D and phosphate (r=−0.87;P〈 0.002). The best correlation was observed in patients with elevated serum creatinine for 1,25-dihydroxyvitamin D and phosphate (r=−0.91;P〈 0.001). The results suggest that low levels of calcium and phosphate stimulate the 1-hydroxylation of 25-hydroxyvitamin D even in advanced age and that the calcium metabolism of these patients is frequently disturbed. Nineteen patients had low levels of 25-hydroxyvitamin D, indicating an insufficient supply of vitamin D or rare exposure to sunlight. In 49 of 50 patients, one ore more of the parameters of calcium metabolism were outside the normal range.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01648584
Permalink
