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  • 1
    Electronic Resource
    Electronic Resource
    Metabolism of carnosine and homocarnosine in subcellular fractions and neuronal and glial cell-enriched fractions of rabbit brain (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb07770.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    THE CEREBELLAR GLOMERULUS: ISOLATION AND METABOLIC PROPERTIES OF A PURIFIED FRACTION (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— A method is described for large scale isolation of glomerular complexes from rabbit cerebellum. The purity of the fraction is 90–95%, measured by quantitative electron microscopy. In addition biochemical markers indicate a high degree of particle integrity. The glomeruli occur as mechanically separable units at 20–40 days of animal age and the amount of protein per particle is 15–20 × 10−11 g. The glomeruli accumulate [3H]GABA, and exhibit both high (Km 15μM) and low (Km 0.5 mM) affinity uptake properties. Glomeruli oxidize α-glycerophosphate and succinate particularly well, while glutamate, pyruvate and α-ketoglutarate are less effective as respiratory substrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb01574.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    NEURONAL AND GLIAL SYSTEMS FOR γ-AMINOBUTYRIC ACID METABOLISM (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 25 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Bulk prepared neuronal perikarya, nerve endings and glial cells have been used to study amino acid concentrations and GABA metabolism in vitro. All amino acids were more concentrated in synaptosomes and glial cells than in neuronal perikarya. Cell specificity was found with respect to the relative distribution of some amino acids. Glutamate decarboxylase activity was considerably higher in synaptosomes than in glial cells. The inhibitory effect of amino-oxyacetic acid on glutamate decarboxylase activity differed between synaptosomes and glial cells. γ-Aminobutyric acid-α-ketoglutarate transaminase had the highest activity in the glial cell fraction; the inhibition of amino-oxyacetic acid differed between glial and neuronal material. The metabolism of exogenous GABA just accumulated by a cell showed similar time characteristics in neuronal and glial material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb04335.x
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  • 4
    Electronic Resource
    Electronic Resource
    CALCIUM FLUXES IN CULTURED AND BULK ISOLATED NEURONAL AND GLIAL CELLS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 29 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The influx and efflux of 45Ca has been studied in cultured human glioma and mouse neuroblastoma cells and in isolated fractions enriched in synaptosomes, neuronal and astrocytic perikarya from rabbit brain.The uptake of 45Ca was somewhat more efficient in glioma compared to neuroblastoma cells, whereas there was little difference in the rate of 45Ca uptake by isolated glial cells and neuronal perikarya. Isolated synaptosomes showed the highest rate of 45Ca accumulation. An increase of K concentration to 50 mm in the medium, with a corresponding lowering of Na, stimulated both glioma and glial as well as synaptosomal 45Ca uptake more markedly than the uptake by neuroblastoma cells and neuronal perikarya. Lowering the Na concentration and replacing it by choline had no effect on the cultured cells and astrocytes. Na-free media caused massive stimulation of 45Ca influx in all fractions and cells tested.The efflux of 45Ca was studied after preloading of cells. Three phases could be resolved from the desaturation curves. All cells had nearly similar half-lives for 45Ca efflux under standard conditions. Pulses of media containing 50 mm-K stimulated 45Ca efflux from glioma cells and astrocytes more efficiently than from neuroblastoma cells, neuronal perikarya and synaptosomes. The stimulated release was exclusively seen in Ca-containing media in experiments with the cultured cells and in Ca-free media in experiments with cell perikarya. The effect of transmitter pulses on the release of 45Ca was examined in a limited series. Acetylcholine and isoproterenol were found to stimulate 45Ca release more actively from glia than from neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb10698.x
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  • 5
    Electronic Resource
    Electronic Resource
    Isolation of highly purified glomerular complexes from rabbit cerebellum (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 221-223 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es wird eine neue Methode zur Präparation der sogenannten «glomerulären Komplexe» aus Kaninchen-Kleinhirn beschrieben, deren komplexe innere Struktur weitgehend intakt bleibt. Mit Hilfe der quantitativen elektronenmikroskopischen Methode wurden über 90% intakter Glomeruli errechnet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990716
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  • 6
    Electronic Resource
    Electronic Resource
    Sound-stimulated14C-glutamate release from the nucleus cochlearis (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 576-577 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The exogenous release of glutamate has been successfully studied in the cochlear nucleus of guinea-pigs after physiological sound stimulation of the ear (frequency 2000–20,000 Hz at 100 dBA).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965810
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    Paper (German National Licenses)
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