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  • 1
    Electronic Resource
    Electronic Resource
    Efficacy and Safety of a Low-Molecular-Weight Heparin and Standard Unfractionated Heparin for Prophylaxis of Postoperative Venous Thromboembolism: European Multicenter Trial (1997)
    Springer
    World journal of surgery 21 (1997), S. 2-9 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A randomized, double-blind multicenter trial was performed to compare the safety and efficacy of a new low-molecular-weight heparin (LMWH) (LU 47311, Clivarine) and standard unfractionated heparin for the prophylaxis of postoperative venous thromboembolism. Altogether 1351 patients scheduled to undergo abdominal surgery were included. Main outcome measures included the incidence of thromboembolic events (deep vein thrombosis, pulmonary embolism, or both) and bleeding complications, including wound hematoma. A total of 655 patients received 1750 anti-Xa IU of LMWH plus a placebo injection daily; 677 patients received 5000 IU of unfractionated heparin (UFH) twice a day. Both drugs were found to be equally effective, as 4.7% of patients in the LMWH group and 4.3% in the UFH group developed postoperative thromboembolic complications. However, the incidence of bleeding complications was significantly reduced in the LMWH group: 55 (8.3%) patients in the LMWH group and 80 (11.8%) in the UFH group developed bleeding complications, a relative risk (RR) of 0.70 (95% CI 0.51–0.97; p = 0.03); wound hematoma occurred in 29 (4.4%) of the LMWH group compared with 55 (7.7%) in those in the UFH group for an RR of 0.57 (95% CI 0.37–0.88; p = 0.01). This study confirmed that a very low dose of 1750 anti-Xa IU daily of this new LMWH is as effective as 10,000 IU of UFH for preventing postoperative deep vein thrombosis. At this dose its administration is associated with a significant reduction in the risk of bleeding including wound hematoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900185
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of Micrometastasis in Bone Marrow of Pancreatic Cancer Patients (1999)
    Springer
    Annals of oncology 10 (1999), S. 111-113 
    Details
    ISSN: 1569-8041
    Keywords: cytokeratins ; immunocytochemistry ; micrometastasis ; monoclonal antibodies ; pancreatic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Design: Here we applied an immunocytochemical cytokeratin assay that allows the identification of individual pancreatic carcinoma cells disseminated to bone marrow. Patients and methods: Prior to therapy, bone marrow was aspirated from the upper iliac crest of 48 patients with ductal adenocarcinoma of the pancreas at various disease stages as well as an age-matched control group of 33 non-carcinoma patients. Tumor cells in cytologic bone marrow preparations were detected with monoclonal antibodies (mAbs) CK2, KL1 and A45-B/B3 to epithelial cytokeratins (CK), using the alkaline phosphatase anti-alkaline phosphatase method. Results: CK+ cells were found in 25 (52.1%) of 48 cancer patients. The overall frequency of these cells was 1 to 85 per 5x 106 mononuclear cells. 4 (8.3%) cancer patients had specimens that stained with the mAb CK2, compared with 16 (33.3%) patients who displayed KL1+ cells and 9 (18.6%) patients who showed A45-B/B3+ cells. After a median follow up of 22.8 (range 3-48) months, the occurrence of tumor relapse was significantly associated with the outcome of the immunocytochemical screening before the time of primary surgery. 6 (40.0%) out of 15 patients who underwent complete surgical resection but had tumor cells in bone marrow presented with distant metastasis and 7 (46.7%) with local relapse as compared to none of 12 corresponding patients without such cells (p〈 0.02). Univariate survival analysis revealed that the presence of CK+ cells in bone marrow was predictive of reduced overall survival (p〈0.03). Conclusions: Anti-CK mAbs are reliable probes for the immunocytochemical detection of single pancreatic cancer cells disseminated to bone marrow. Thus the described technique may help to identify patients with pancreatic cancer and potential high risk of early metastic relapse. The results promise to be of important assistance in determining prognosis and consequences in therapy of early stage pancreatic cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008365525740
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  • 3
    Electronic Resource
    Electronic Resource
    Chirurgisches Vorgehen beim Ulcus ventriculi und Ulcus duodeni (1998)
    Springer
    Der Chirurg 69 (1998), S. 588-596 
    Details
    ISSN: 1433-0385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050461
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of loss of heterozygosity and microsatellite instability in adenocarcinomas of the distal esophagus and proximal stomach (2000)
    Springer
    Virchows Archiv 437 (2000), S. 605-610 
    Details
    ISSN: 1432-2307
    Keywords: Adenocarcinoma Gastroesophageal junction Loss of heterozygosity Microsatellite instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Adenocarcinoma of the gastroesophageal junction is rapidly rising in incidence. It has been proposed that these tumors be classified as three different types: distal esophageal (AEG I), cardia (AEG II), and subcardia (AEG III). Using comparative genomic hybridization (CGH) analysis, one recent study reported that the 14q chromosomal arm showed a significantly higher rate of deletion in esophageal than in cardia adenocarcinoma. Using a microsatellite analysis technique, we analyzed this area and regions in the vicinity of the APC, DCC, and p53 genes. Tumor and normal tissues were microdissected from 54 cases (27 AEG I and 27 AEG III). DNA was extracted and then amplified using seven fluorescent-labeled microsatellite markers, one pair each on 5q, 18q, and 17p and four on 14q. The results were analyzed for loss of heterozygosity (LOH) and microsatellite instability (MSI). LOH varied from 20% to 30% at each locus except for the 17p locus, where it was slightly above 50% in both groups. No significant differences in LOH or MSI were found between the esophageal and gastric tumors, including the 14q chromosomal arm. These results fail to confirm the finding that abnormalities on the 14q chromosomal arm distinguish between distal esophageal and proximal gastric tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000322
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  • 5
    Electronic Resource
    Electronic Resource
    Das Magenkarzinom (2000)
    Springer
    Der Internist 41 (2000), S. 817-830 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Magenkarzinom ; Staging ; Chirurgische Strategie ; Multimodale Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Die Zeiten, in denen die Diagnose “Magenkarzinom” gleichbedeutend mit einer Operation waren, sind vorbei. Heutzutage ermöglicht die moderne Diagnostik eine sehr genaue Erfassung der individuellen Tumorsituation jedes Patienten. Dies ermöglicht in den meisten Fällen eine maßgeschneiderte, individuelle Therapie, die in diesem Beitrag beschrieben wird. Die Ergebnisse der minimal-invasiven und chirurgischen Therapie werden ebenso wie die der adjuvanten und neoadjuvanten Chemotherapie diskutiert. Ein Ausblick gibt Hinweise darauf, wie es in Zukunft möglich sein kann, die Prognose für die einzelne Subgruppen noch weiter zu verbessern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050634
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