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  • 1
    Electronic Resource
    Electronic Resource
    Intestinale neuronale Dysplasie des Erwachsenen als Ursache der chronischen Obstipation Morphometrische Charakterisierung der Coloninnervation (1999)
    Springer
    Der Chirurg 70 (1999), S. 771-776 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Intestinal neuronal dysplasia ; Chronic constipation ; Morphometry ; Submucous plexus. ; Schlüsselwörter: Intestinale neuronale Dysplasie ; chronische Obstipation ; Morphometrie ; Plexus submucosus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Die intestinale neuronale Dysplasie (IND) ist eine ursprünglich bei Kindern beschriebene Entwicklungsstörung des Plexus submucosus. In den letzten Jahren ließ sich diese Anomalie auch beim Erwachsenen mit chronischer Obstipation beobachten. Das Ziel der vorliegenden Arbeit bestand in einer morphometrischen Objektivierung dieses Krankheitsbildes. Die Untersuchung wurde vergleichend an Biopsien von 10 Erwachsenen mit IND und 10 Kontrollprobanden durchgeführt. Als bester diagnostischer Indikator einer IND erwies sich der Nachweis von 6–10 Riesenganglien mit mehr als 7 Nervenzellen in 15 Biopsieschnitten. Die IND stellt eine interessante histologisch verifizierbare Ursache einer chronischen Obstipation des Erwachsenen dar.
    Notes: Summary. Intestinal neuronal dysplasia (IND) was initially described as a developmental abnormality of the submucous plexus in children. In recent years this abnormality has also been observed in adults with chronic constipation. The aim of this study was a morphometric characterization of this disease. The investigation was performed with 10 adults with IND, compared with 10 healthy control probands. The best diagnostic indicator of IND proved to be the detection of 6–10 giant ganglia with more than 7 nerve cells in 15 biopsy sections. IND is an interesting cause of chronic constipation which can be histologically verified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050720
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  • 2
    Electronic Resource
    Electronic Resource
    Histopathological criteria for intestinal neuronal dysplasia of the submucosal plexus (type B) (1995)
    Springer
    Virchows Archiv 426 (1995), S. 549-556 
    Details
    ISSN: 1432-2307
    Keywords: Intestinal neuronal dysplasia (type B) ; Submucosal plexus ; Colorectal innervation defects ; Hypoganglionosis ; Myenteric plexus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to review critically the diagnostic features of intestinal neuronal dysplasia type B (IND B). Over a period of 5 years colonic mucosal biopsies of 773 children with symptoms of chronic constipation were examined. Four biopsies taken 2–10 cm above the pectinate line were cut in serial sections and histochemical lactate dehydrogenase, succinate dehydrogenase, (SDH) and acetylcholinesterase (AChE) reactions performed. Presence of giant ganglia of the submucosal plexus, being characterized by more than seven nerve cells, established the diagnosis of IND B. Giant ganglia were found to be age-independent changes, while hyperplasia of the submucosal plexus, increase of AChE activity in nerve fibres of the lamina propria and low SDH activity in nerve cells proved to be age-dependent findings which disappear during the maturation of the enteric nervous system. Using these criteria IND B was diagnosed in 209 children. In 64 of these patients a combination of IND B and aganglionosis (Hirschsprung's disease) was found. IND B seems to be related to premature expression of laminin A during embryogenesis, resulting in premature nerve cell differentiation in the myenteric and submucosal plexus, which in turn blocks neuroblast colonization of the rectum. IND B, hypoganglionosis and aganglionosis, which are often combined, may therefore be considered to be different manifestations of the same developmental abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192108
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  • 3
    Electronic Resource
    Electronic Resource
    Neuronal dysplasia (1990)
    Springer
    International journal of colorectal disease 5 (1990), S. 106-112 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intestinal muscle and the autonomic nervous system constitute a neuromuscular unit. A clinical study was undertaken to seek neurogenic causes of impaired motility affecting the rectosigmoid junction and rectum. Patients with primary chronic constipation were shown by enzyme-histochemical examination of biopsies to have neuronal colonic dysplasia of the rectosigmoid, whereas the latter was normally innervated in healthy controls. The present investigations provide a fresh insight, underpinned by histological findings, into the aetiology of chronic constipation and make a contribution to its operative treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298481
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  • 4
    Electronic Resource
    Electronic Resource
    The cholecystogastric fistula (1991)
    Springer
    Surgical endoscopy and other interventional techniques 5 (1991), S. 46-47 
    Details
    ISSN: 1432-2218
    Keywords: Cholecystogastric fistula ; Gallbladder perforation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Internal gall bladder fistulas with a hollow viscus following dislocation of a gallstone into the intestine represent one of the late sequelae of cholelithiasis. We report the case of a 78-year-old patient, who suffered from a cholecystogastric fistula with consecutive stone transmigration into the stomach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591387
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  • 5
    Electronic Resource
    Electronic Resource
    128. Synchrones Auftreten von Hyperthyreose und Schilddrüsencarcinom im Struma-Endemiegebiet (1985)
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 594-594 
    Details
    ISSN: 1435-2451
    Keywords: Thyroid carcinoma ; Hyperthyroidism ; Simultaneous occurrence ; Cytodiagnosis ; Schilddrüsencarcinom ; Hyperthyreose ; Synchrones Auftreten ; Cytodiagnostik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter 122 Patienten mit Schilddrüsencarcinom fanden sich 19 Fälle (15%), die in Kombination mit dem Carcinom eine Hyperthyreose aufwiesen (3 Männer, 16 Frauen. Alter 32–72 Jahre). Der Krebs war bei 16 Patienten in einem autonomen Adenom und bei 3 in einem inaktiven Knoten nachzuweisen. 10mal lag ein papilläres, 9mal ein folliculäres Carcinom vor. Die präoperative Feinnadelpunktion ergab bei 8 Kranken Pap III und bei 2 Pap IV. Es empfiehlt sich die konsequente präoperative Cytodiagnostik aller, auch heißer Strumaknoten.
    Notes: Summary Of 122 patients with thyroid carcinoma, 19 (15%) also suffered from hyperthyroidism (3 men, 16 women, aged 32–72 years). Sixteen patients had a malignant autonomous adenoma and 3 had a malignant inactive nodule. A papillary carcinoma was observed ten times and a follicular carcinoma nine times. Preoperative fine-needle puncture showed Pap III in 8 patients and Pap IV in 2. Consistent preoperative cytodiagnosis of all struma nodules, including hot nodules, is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836727
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    Paper (German National Licenses)
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