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  • 1
    Electronic Resource
    Electronic Resource
    Differential Effect of the Activation of Protein Kinase A on the Protein Synthesis and Secretion in the T-Helper 2 Cell Line D10.G4.1 (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 44 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The authors analysed the effect of protein kinase A (PKA) activation on the protein synthesis and secretion in the T-helper 2 cell line D10.G4.1 (D10) using an assay that allows the detection of almost all secreted proteins of a cell. IL-4 and IL-10 were quantified. Three groups of secretory products could be defined. The T-cell receptor (TCR)-induced production of the first group (A) of proteins including IL-4 was enhanced by low concentrations of PKA activators. At higher concentrations the enhancement was less marked. The synthesis and secretion of a second group (B) of proteins including IL-10 remained unaffected. The production of a third group (C) of proteins was inhibited in a concentration-dependent manner. Biochemical analysis revealed a block of phospholipase C γ (PLCγ) activity by PKA activators. When D10 cells were stimulated by a phorbol ester plus calcium ionophore the production of group A proteins was enhanced almost fourfold, whereas production of group B proteins was unaffected by PKA activation. This effect was observed at all concentrations of various PKA activators tested. The secretion of group C proteins was no longer inhibited. The same results were obtained when analysing IL-4 and IL-10 m-RNA by Northern blotting. The data demonstrate a lymphokine specific mode of action on a single cell basis. Furthermore, it suggests that the inhibitory action of PKA in D10 cells is due partly to blocking of PLCγ activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-295.x
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  • 2
    Electronic Resource
    Electronic Resource
    Primary non-Hodgkin's lymphoma of the vagina case report and review of the literature (1995)
    Springer
    Annals of hematology 70 (1995), S. 273-276 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin's lymphoma ; Reproductive organs ; Vaginal lymphoma ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784047
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Primary non-Hodgkin's lymphoma of the vagina Case report and review of the literature (1995)
    Springer
    Annals of hematology 70 (1995), S. 273-276 
    Details
    ISSN: 1432-0584
    Keywords: Key words Non-Hodgkin's lymphoma ; Reproductive organs ; Vaginal lymphoma ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784047
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    c-kit mutation and osteopetrosis-like osteopathy in a patient with systemic mast cell disease (1998)
    Springer
    Annals of hematology 77 (1998), S. 131-134 
    Details
    ISSN: 1432-0584
    Keywords: Key words Mastocytosis ; Mast cell disease ; c-kit ; Osteopetrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We describe the case of a 69-year-old man with systemic mastocytosis and severe osteopetrosis who carries a somatic activating mutation in the c-kit proto-oncogene. The patient initially presented with urticaria pigmentosa, progressing to systemic mast cell disease with severe anemia due to bone marrow involvement, chronic diarrhea, and hepatosplenomegaly. Direct sequencing using amplimers from reverse transcriptase-polymerase chain reactions (RT-PCR) from skin mast cell-derived RNA revealed a point mutation in the c-kit proto-oncogene at position 2468, introducing a new recognition site for the restriction endonuclease HinfI. Treatment with interferon-alpha 2a, prednisone, and erythropoietin was initiated. Subsequently, clinical sysmptoms improved significantly and hemoglobin levels are now stable at 13 g/dl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050428
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    Paper (German National Licenses)
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