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  • 1
    Electronic Resource
    Electronic Resource
    Stewart-treves syndrome. A report of two cases with a review of Japanese literature (1987)
    Springer
    Surgery today 17 (1987), S. 407-412 
    Details
    ISSN: 1436-2813
    Keywords: Stewart-Treves syndrome ; postmastectomy lymphangiosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two cases of postmastectomy lymphangiosarcoma seen at our department are reported. One case, treated by amputation, died 1 year 4 months later and the other case, treated by local excision followed by amputation, died 7 months later. Twenty cases from the Japanese literature, including our 2 cases, are reviewed herein. The initial treatment for the other 18 cases was as follows: amputation in 8 cases, local excision in 2, radiotherapy in 4 and chemotherapy in 4. Fifteen of 16 cases eligible for follow up were dead within 20 months after treatment. Although the knowledge available as to the results of the treatment of postmastectomy lymphangiosarcoma is still insufficient to indicate the optimal therapeutic approach, early recognition of the lesion and prompt radical ablative surgery seem to offer the best chance for survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470642
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  • 2
    Electronic Resource
    Electronic Resource
    Extraskeletal myxoid chondrosarcoma with multiple skeletal metastases (2000)
    Springer
    Journal of orthopaedic science 5 (2000), S. 171-174 
    Details
    ISSN: 1436-2023
    Keywords: Key words: extraskeletal myxoid chondrosarcoma, multiple bone metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Pulmonary metastases are not unusual in extraskeletal myxoid chondrosarcoma; however, only two patients have been reported with multiple bony metastases. We report here one patient with extraskeletal myxoid chondrosarcoma associated with lung and multiple bony metastases. After chemotherapy, the primary lesion was resected, but lung and multiple bony metastases were found 20 months later. The bony metastases were in the right femur, right humerus, and at multiple vertebral levels. Because of a pathologic fracture of the right femur, the metastases in the right femur and right humerus were surgically stabilized. After chemotherapy, the lung metastases were resected, and those in the vertebral bodies were treated with radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007760050145
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  • 3
    Electronic Resource
    Electronic Resource
    Human tumor clonogenic assay in osteosarcoma for evaluation of clinical efficacy of anti-cancer drugs (1986)
    Springer
    Cancer chemotherapy and pharmacology 18 (1986), S. 133-136 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-three specimens (biopsied tissue, resected specimens, and resected pulmonary metastases were obtained during biopsy, radical surgery, or thoracotomy from patients with osteosarcoma. Using these specimens, human tumor clonogenic assay (standard HTCA) and cultivated HTCA (HTCA using single-cell suspensions obtained from short-term cultures) were carried out. The percentage of colony-forming ability, which was very small for standard HTCA, increased significantly when cultivated HTCA was performed. With cultivated HTCA, sensitivity tests were possible in 87% of the specimens in contrast to only 28.6% using standard HTCA. We retrospectively analyzed the relationship between the results of HTCA and the clinical efficacy of agents such as methotrexate, adriamycin, cis-platinum, and vincristine, which are frequently prescribed for the treatment of osteosarcoma. This analysis revealed that if drugs are show to be ineffective by this test, they can be regarded as clinically ineffective against that specific tumor target, i. e., the tumor cells are refractory to those drugs. Thus, clinical use of such drugs should be avoided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262282
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistological study on collagenous proteins of benign and malignant human cartilaginous tumours of bone (1990)
    Springer
    Virchows Archiv 417 (1990), S. 291-297 
    Details
    ISSN: 1432-2307
    Keywords: Chondrosarcoma ; Chondroma ; Collagen ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunohistological distribution of collagen types I, II, III, V and VI in human benign and malignant cartilaginous tumours of bone was examined with regard to their aggressiveness. The matrix of enchondromas consisted of type II collagen distributed diffusely, and type VI predominantly localized in the immediate surroundings of the cells. Types I, III and V collagen were not found. These findings were similar to the distribution of collagenous proteins in normal hyaline cartilage where each lobule was consistently rimmed by types I and V collagen. In grade 1 chondrosarcomas, the main collagenous components of matrix were also types II and VI collagen. Type II was sometimes found in the cytoplasm of tumour cells and type VI tended to lose territorial localization. In addition, type I collagen was demonstrated consistently and type V in some cases. In grade 2 chondrosarcomas, type II collagen was demonstrated not only in the matrix but occasionally in the cytoplasm of tumour cells. Type VI was dispersed in the intercellular areas. The other collagenous proteins such as types I, III and V were also present in the matrix. In grade 3 chondrosarcomas, type II collagen was localized predominantly in the cytoplasm of tumour cells and in the adjacent matrix. Type VI was markedly decreased with complete loss of pericellular distribution, whereas types I, III and V were constantly present in the matrix. Those alterations in the distribution of collagen types correlated well with the aggressive behaviour of the tumours. The findings suggest that distribution of different collagen types in cartilaginous tumours reflects the immaturity of the tumour cells and is a useful indicator of their aggressiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605779
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  • 5
    Electronic Resource
    Electronic Resource
    Microfilamentous type VI collagen in the hyalinized stroma of the hypertrophied ligamentum flavum (1991)
    Springer
    Virchows Archiv 419 (1991), S. 373-380 
    Details
    ISSN: 1432-2307
    Keywords: Ligamentum flavum ; Type VI collagen ; Hyalinization ; Spinal canal stenosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thickened ligamenta flava obtained from 14 patients with spinal canal stenosis were examined with special reference to type VI collagen. The characteristic histological finding in the thickened area was rupture of normal elastic fibre meshwork with resultant fibrosis which usually appeared hyaline. Using an immunohistological method, collagen types VI, I and III were found to be present in the hyaline matrix. Ultrastructural study revealed many microfilamentous structures of type VI collagen admixed in loosely packed, banded collagen fibres. With differential salt precipitation of pepsin-extracted collagen the existence of type VI collagen was confirmed by SDS-polyacrylamide gel electrophoresis analysis and Western blotting analysis using anti-type VI collagen antibody. Quantification of type VI collagen in pepsin-extracted crude collagen samples by an inhibition enzyme-linked immunosorbent assay showed an increasing amount of type VI collagen in the thickened ligamenta flava compared to the normal ligaments. Thus, increase of type VI collagen is the main contribution to the thickening of the ligamentum flavum. This may represent an adaptational and reparative process associated with disruption of elastic fibres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605070
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  • 6
    Electronic Resource
    Electronic Resource
    Snapping of the proximal interphalangeal joint due to the lateral band (2000)
    Springer
    Archives of orthopaedic and trauma surgery 120 (2000), S. 531-532 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unusual case is reported of snapping of the proximal interphalangeal joint (PIPJ) of the right little finger in a 14-year-old girl. The lateral band of the radial side slipped over the peak of the condyle of the proximal phalanx at 40 deg of flexion. The lateral band was cut and sutured to the central slip. At follow-up examination 4 months later, there had been no recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004029900101
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  • 7
    Electronic Resource
    Electronic Resource
    Three-dimensional topographic analysis of spinal accessory motoneurons under chronic mechanical compression: an experimental study in the mouse (1997)
    Springer
    Journal of neurology 244 (1997), S. 222-229 
    Details
    ISSN: 1432-1459
    Keywords: Key words Spinal accessory nerve ; Motoneuron ; Three-dimensional topography ; Wheat germ agglutinin-horseradish peroxidase ; Tiptoe-walking Yoshimura (twy) mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effect of chronic mechanical compression of the cervical spinal cord on the number of spinal accessory motoneurons in 25 tiptoe-walking Yoshimura mice. The animals had calcified deposits in the atlantoaxial membrane at the C1–C2 vertebral level, compressing the spinal cord posterolaterally. Motoneurons of the spinal accessory nerve between C1 and C5 segments were labelled using wheat germ agglutinin-horseradish peroxidase (WGA-HRP) injected into the sternocleidomastoid muscles. The counted cells were processed into a three-dimensional computer display to analyse the cytoarchitectonic changes caused by external cord compression. The number of WGA-HRP-labelled spinal accessory motoneurons was significantly reduced on the affected side. The number of motoneurons in compromised C2 and C3 cord segments correlated linearly with the extent of mechanical compression, but no such relationship was present on the contralateral side. There was an increase in the number of WGA-HRP-labelled spinal accessory motoneurons in the medial cell pools of the anterior grey horn at a level most rostral to the compression, and in the ventrolateral cell pools at levels immediately rostral to the compression. Our findings suggest that the spinal accessory motoneurons translocate rostral to the area of external compression in order to avoid mechanical injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050076
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  • 8
    Electronic Resource
    Electronic Resource
    Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse (1996)
    Springer
    Journal of neurology 243 (1996), S. 109-116 
    Details
    ISSN: 1432-1459
    Keywords: Spinal cord compression ; Motoneuron ; Topography ; Nissl stain ; Tiptoe-walking Yoshimura (twy) mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated quantitative changes in spinal cord motoneurons following chronic compression using a mouse model of cervical cord compression. Twenty-five tiptoe-walking Yoshimura (twy) mice with calcified mass lesions compressing the spinal cord posterolaterally at the C1–C2 vertebral levels were compared with five Institute of Cancer Research (ICR) mice that served as controls. Spinal cord motoneurons in the anterior grey horn between the C1 and C3 spinal cord segments were Nissl-stained and counted topographically and then analysed in relation to the extent of spinal cord compression. The number of motoneurons in C1–C3 spinal cord segments decreased significantly with a linear correlation with the transverse area of the spinal cord when the cord was compressed to 50–70% of control values. A significant reduction in the number of motoneurons occurred at the C2–C3 spinal cord segment compressed at the C1–C2 vertebral level. In contrast, at the level rostral to the C1 vertebra, the number of motoneurons increased significantly in proportion to the magnitude of compression. The current study demonstrates that a number of neurons, morphologically consistent with anterior horn cells, were observed at a rostral site absolutely free of external compression where no such cells normally exist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443999
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  • 9
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of collagenous proteins in cartilaginous tumors: characteristic distribution of type IX collagen (1993)
    Springer
    Journal of cancer research and clinical oncology 120 (1993), S. 35-40 
    Details
    ISSN: 1432-1335
    Keywords: Chondrosarcoma ; Enchondroma ; Collagen IX ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distinctive tissue localization of collagen types, particularly of type IX collagen in human cartilaginous tumors (10 cases of enchondroma and 15 cases of chondrosarcoma including 3 cases of secondary chondrosarcoma) was examined immunohistochemically using affinitypurified antibodies against types I, II, III, V, VI, and IX collagen, in comparison with that in human fetal cartilage. In fetal cartilage matrix, types II and IX collagen were diffusely distributed, while types I, III, and V collagens were not present. In the matrices of enchondromas and primary chondrosarcomas, types II and IX collagens were also diffusely distributed, but with some areas of irregular type IX collagen deposits. The secondary chondrosarcoma simulated normal fetal cartilage in the distribution pattern of types II and IX collagen, unlike the pattern in primary chondrosarcoma, where types II and IX collagen were decreased and poorly immunostained, whereas non-cartilaginous interstitial collagens (I, III, and V) appeared diffusely in the matrix, increasing with the grade of malignancy. These findings suggest that neoplastic cartilage is characterized initially by an uneven distribution of type IX collagen, prior to any alteration of other types of collagen; the diverse expressions of intercellular components in cartilaginous tumors may be one indicator for malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200722
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  • 10
    Electronic Resource
    Electronic Resource
    Case report 741 (1992)
    Springer
    Skeletal radiology 21 (1992), S. 339-342 
    Details
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00241778
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