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  • 1
    Electronic Resource
    Electronic Resource
    Contribution to scientific research in paediatrics in The Netherlands: evaluation according to subspeciality over a 10-year period (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 870-872 
    Details
    ISSN: 1432-1076
    Keywords: Scientific research ; Paediatrics ; The Netherlands ; Quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The board of the Dutch Paediatric Association requested a survey of the scientific research performed in all academic and non-academic paediatric hospitals, authorized to train medical doctors in paediatrics in the Netherlands. Contributions to the international and the Dutch scientific literature, in the form of regular publications, chapters in books, contributions to proceedings and Ph.D. theses were counted over two 5-year periods, i.e. 1981–1985 and 1986–1990. The quality of publications in the international journals was assessed using the average impact factor of the journals over the 10-year period. The number of publications in the international literature doubled during the observation period 1986–1990 compared to the period 1981–1985. Nevertheless, the quality of the publications remained the same. Metabolism, oncology/ haematology, immunology/infectious diseases and cardiology are the subspecialisations in which scientific research takes place in four or more academic paediatric hospitals. In total, 84 Ph.D. theses were produced in which a paediatrician was either the project leader (mostly a professor in paediatrics) or the investigator-in-charge. Insight into structure and major research efforts of paediatric hospitals in other countries of Europe may lead to exchange of views and, maybe, profitable co-operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957518
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  • 2
    Electronic Resource
    Electronic Resource
    Intensification of GVHD prophylaxis interferes with the effects of pretransplant herpes virus serology on the occurrence of grades II–IV acute graft-versus-host disease (1992)
    Springer
    Annals of hematology 64 (1992), S. A137 
    Details
    ISSN: 1432-0584
    Keywords: Bone marrow transplantation ; Graft-versus-host-disease ; Herpes viruses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of pretransplant herpes virus serology on the occurrence of grades II–IV acute graft-versus-host disease (GVHD) were studied in 262 recipients and their HLA-identical family donors. In 131 recipients on standard GVHD prophylaxis (either methotrexate or cyclosporin A) significant effects were observed for donor HSV serology (seropositivity associated with increased risk for GVHD) and donor EBV serology (seronegativity associated with increased risk). However, these effects were nonsignificant in the other 131 recipients on intensified GVHD prophylaxis (i.e., methotrexate combined with cyclosporin A, in vivo anti-T-cell monoclonal antibodies, or various procedures to reduce the T-cell numbers in the transplants).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715367
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  • 3
    Electronic Resource
    Electronic Resource
    Epstein-Barr virus infection in allogeneic marrow grafting: lessons for transplant physicians and virologists (1992)
    Springer
    Annals of hematology 64 (1992), S. A162 
    Details
    ISSN: 1432-0584
    Keywords: Bone marrow transplantation ; Epstein ; Barr virus ; Infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between Epstein-Barr virus (EBV) and the host is profoundly disturbed by allogeneic bone marrow transplantation (BMT) because EBV resides in the recipient's hematopoietic system, which has to be destroyed in the majority of cases, and in the donor's hematopoietic system, i.e., the marrow graft. We have shown that EBV may be eradicated from some BMT recipients and that the virus may be transferred with the marrow graft. During the immediate post-transplant period oropharyngeal EBV excretion may occur which, by infecting passing B lymphocytes, may act as co-factor for acute graft-versus-host disease and help the virus to survive, despite the temporary depletion of its reservoir. The coexistence of totally different EBV strains in BMT recipients but not in healthy, untransfused controls, suggests that superinfection may by possible in case of immunodeficiency; alternatively, transfer of the virus by the reservoir itself (the B lymphocytes) might be the only effective route for superinfection. The generation of ‘variant’ strains during viral replication may form the basis of the vast polymorphism between wild-type EBV isolates in the population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715373
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  • 4
    Electronic Resource
    Electronic Resource
    Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene (2000)
    Springer
    Immunogenetics 51 (2000), S. 42-49 
    Details
    ISSN: 1432-1211
    Keywords: Key words Bare lymphocyte syndrome ; MHC class II deficiency ; MHC class II transactivator (CIITA) ; Immunodeficiency ; Gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  MHC class II deficiency patients are mutated for transcription factors that regulate the expression of major histocompatibility complex (MHC) class II genes. Four complementation groups (A–D) are defined and the gene defective in group A has been shown to encode the MHC class II transactivator (CIITA). Here, we report the molecular characterization of a new MHC class II deficiency patient, ATU. Cell fusion experiments indicated that ATU belongs to complementation group A. Subsequent mutation analysis revealed that the CIITA mRNA lacked 84 nucleotides. This deletion was the result of the absence of a splice donor site in the CIITA gene of ATU. As a result of this novel homozygous genomic deletion, ATU CIITA failed to transactivate MHC class II genes. Furthermore, this truncated CIITA of ATU did not display a dominant negative effect on CIITA-mediated transactivation of various isotypic MHC class II promoters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050007
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  • 5
    Electronic Resource
    Electronic Resource
    Prevalence of penicillin-resistant viridans streptococci in healthy children and in patients with malignant haematological disorders (1994)
    Springer
    European journal of clinical microbiology & infectious diseases 13 (1994), S. 645-650 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prevalence of penicillin-resistant viridans streptococci was studied in healthy children and in paediatric and adult patients with leukaemia to determine whether the frequent presence of penicillin-resistant streptococci in the oral cavity of children with leukaemia is the result of antibiotic therapy. Twenty of the oral swabs from 50 healthy children who had not received antibiotics in the three months prior to sampling yielded viridans streptococci that could be cultured on blood agar containing 2 µg/ml benzylpenicillin. In 11 of the 20 cases the streptococci were resistant to penicillin (MIC≥4µg/ml). This prevalence is significantly higher than that found in adult leukaemia patients (40 % vs. ≤5 %) but is about the same as that found in paediatric patients with leukaemia. The high prevalence of penicillin-resistant streptococci in the paediatric age group should be considered when selecting therapy and prophylaxis, especially when the risk of infection with one of these cocci is enhanced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973990
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    Paper (German National Licenses)
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