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  • 1
    Electronic Resource
    Electronic Resource
    Murder involving discovery and first application of fluorescence of tyre prints (1974)
    [s.l.] : Nature Publishing Group
    Nature 250 (1974), S. 762-764 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] PART of the evidence for the prosecution in a recent case of murder arose from the discovery by the investigating police officers of a set of fluorescent tyre prints. In our view the discovery will initiate developments of widespread significance to forensic science. We wish to describe, therefore, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/250762a0
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  • 2
    Electronic Resource
    Electronic Resource
    The disposition of biphenylacetic acid following topical application (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 639-642 
    Details
    ISSN: 1432-1041
    Keywords: biphenylacetic acid ; plasma and synovial fluid concentrations ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma and synovial fluid concentrations of biphenylacetic acid were determined following application of 3 g of 3% biphenylacetic acid gel to one knee of patients suffering from rheumatoid arthritis. The mean peak plasma concentration was 34 ng/ml. Synovial fluid concentrations tended to follow plasma concentrations but at a somewhat lower level, the mean peak synovial fluid concentration was 21 ng/ml. The average ratio of synovial fluid AUC (0–24 h) to plasma AUC (0–24 h) was 0.58, r=0.97. Where patients had bilateral effusions, the concentration in the ipsilateral knee at each time point examined was not significantly different to that in the contralateral knee, suggesting that absorption was initially into the plasma and subsequently into the synovium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542502
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  • 3
    Electronic Resource
    Electronic Resource
    Preliminary observations on the biliary elimination of mebendazole and its metabolites in patients with echinococcosis (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 81-84 
    Details
    ISSN: 1432-1041
    Keywords: mebendazole ; echinococcosis ; metabolism ; biliary excretion ; hepatic damage ; hepatic clearance ; conjugate formation ; plasma level
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The biliary excretion of mebendazole has been investigated in two patients to whom it was given for the treatment of echinococcosis, although it was found to be only partly effective. Oral mebendazole was extensively metabolized and the conjugated parent substance and its metabolites were excreted in the bile. One patient without cholestasis and with normal liver function had an apparent total biliary clearance (776 ml/min) which approached the hepatic plasma flow. The other patient with cholestasis and impairment of the hepatic drug metabolizing capacity showed a drastically reduced apparent total biliary clearance of 3.8 ml/min. The average plasma level of mebendazole was significantly lower in the former and higher in the latter patient (0.06 and 0.91 nmol/ml, respectively). The data suggest that impaired metabolism and/or biliary elimination can account for the higher plasma mebendazole level in patients with liver damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544020
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 161-169 
    Details
    ISSN: 1432-1041
    Keywords: mebendazole ; hydatid disease ; Echinococcus granulosus ; hepatic disease ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentrations of mebendazole and its metabolites have been monitored in twelve patients after receiving a 10 mg/kg dose for cystic hydatid disease. The mebendazole plasma concentration-time profiles differed considerably between patients; elimination half-lives ranged from 2.8–9.0 h, time to peak plasma concentration after dosing ranged from 1.5–7.25 h and peak plasma concentrations ranged from 17.5 to 500 ng/ml. The mean peak plasma concentration of mebendazole after an initial dose (69.5 ng/ml) was lower than found in patients during chronic therapy (137.4 ng/ml). The plasma AUCTs for the major metabolites of mebendazole (methyl 5-(α-hydroxybenzyl)-2-benzimidazole carbamate and 2-amino-5 benzoylbenzimidazole) were about five times the plasma AUCT found for mebendazole in patients on chronic therapy. It is suggested that the slower clearance of these polar metabolites relative to mebendazole results from enterohepatic recycling. Since mebendazole is also highly plasma protein bound, caution should be observed in administering mebendazole to patients with liver disease. Concentrations of mebendazole found in the tissue and cyst material collected from two patients during surgery ranged from 59.5 to 206.6 ng/g wet weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542462
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  • 5
    Electronic Resource
    Electronic Resource
    Cardenolide connection between overwintering monarch butterflies from Mexico and their larval food plant,Asclepias syriaca (1986)
    Springer
    Journal of chemical ecology 12 (1986), S. 1157-1170 
    Details
    ISSN: 1573-1561
    Keywords: Danaus plexippus ; monarch butterflies ; Lepidoptera ; Danaidae ; Asclepiadaceae ; milkweeds ; Asclepias syriaca ; Asclepias speciosa ; ecological chemistry ; chemical defense ; cardenolides ; aspecioside ; desglucosyrioside ; syriobioside ; overwintering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The majority (85%) of 394 monarch butterflies sampled from overwintering sites in Mexico contain the same epoxy cardenolide glycosides, including most conspicuously a novel polar glycoside with a single genin-sugar bridge (aspecioside), as occur in the milkweedsAsclepias speciosa andA. syriaca. This cardenolide commonality was established by isolating aspecioside and syriobioside from the wings of overwintering monarchs and the two plant species, and comparing Chromatographie and NMR spectrometric characteristics of the isolates. When combined with the migratory pattern of monarchs and the distribution of these two milkweed species, this chemical evidence lends strong support to the hypothesis thatA. syriaca is the major late summer food plant of monarchs in eastern North America. This finding may be of ecological importance, forA. syriaca contributes less cardenolide and cardenolides of lower emetic potency to monarchs than most milkweeds studied to date.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01639002
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  • 6
    Electronic Resource
    Electronic Resource
    Quantification of leukotriene B4 in synovial fluid by gas chromatography/tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 17 (1988), S. 205-211 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A procedure for the quantification of leukotriene B4 (LTB4) in synovial fluid has been developed using gas chromatography/tandem mass spectrometry based on selected reaction monitoring of the elimination of t-butyldimethylsilanol from the ions of m/z 431 and 438 in the negative ion chemical ionization mass spectra of the di-t-butyldimethylsilyl/pentafluorobenzyl derivatives of derivatives of leukotriene B4 and the internal standard (2H8)leukotriene B4. The detection limit (∼10 pg ml-1) is sufficiently low to permit determination of LTB4 concentration in the synovial fluid of patients with various arthropathies. Single-stage mass spectrometry was found not to be selective enough to permit quantification of LTB4 in synovial fluid.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200170309
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  • 7
    Electronic Resource
    Electronic Resource
    The mass spectra of hydroxyquinolizidines (1970)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 4 (1970), S. 109-119 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of 1-, 2- and 3-hydroxyquinolizidine have been determined. In all cases the elimination of an hydroxyl radical is a more favoured process than the elimination of water. This has been substantiated by specific deuterium labelling. The fragmentation patterns of the three isomers allow for each compound to be identified specifically.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210040112
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