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  • 1
    Electronic Resource
    Electronic Resource
    Raised plasma kininogen levels in rheumatoid patients—Response to therapy with nonsteroidal anti-inflammatory drugs (1976)
    Springer
    Inflammation research 6 (1976), S. 449-450 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973257
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  • 2
    Electronic Resource
    Electronic Resource
    A novel relationship between plasma kininogen and rheumatoid disease (1976)
    Springer
    Inflammation research 6 (1976), S. 147-153 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma kininogen levels in the peripheral venous blood of untreated patients with active rheumatoid disease was found to be more than twice the levels measured in healthy normal individuals or in convalescing uncomplicated fracture patients. Treatment with oral indomethacin or aspirin lowered the kininogen levels nearly to normal. Sequential studies showed that the fall in kiniogen was very rapid, occurring within 1–2 hours of ingestion of drug, and was parallelled by reduction in the clinical indices of inflammation. Control studies showed that the kininogen changes were not due to changes in plasma volume or non-specific changes in plasma protein concentration. Indomethacin treatment had no effect on plasma kininogen levels in healthy volunteers. The significance of this finding will be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972199
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  • 3
    Electronic Resource
    Electronic Resource
    The disposition of biphenylacetic acid following topical application (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 639-642 
    Details
    ISSN: 1432-1041
    Keywords: biphenylacetic acid ; plasma and synovial fluid concentrations ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma and synovial fluid concentrations of biphenylacetic acid were determined following application of 3 g of 3% biphenylacetic acid gel to one knee of patients suffering from rheumatoid arthritis. The mean peak plasma concentration was 34 ng/ml. Synovial fluid concentrations tended to follow plasma concentrations but at a somewhat lower level, the mean peak synovial fluid concentration was 21 ng/ml. The average ratio of synovial fluid AUC (0–24 h) to plasma AUC (0–24 h) was 0.58, r=0.97. Where patients had bilateral effusions, the concentration in the ipsilateral knee at each time point examined was not significantly different to that in the contralateral knee, suggesting that absorption was initially into the plasma and subsequently into the synovium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542502
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 253-261 
    Details
    ISSN: 1432-1041
    Keywords: aspirin ; pharmacokinetics ; salicylate ; alcoholic liver disease ; young and elderly volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of the pharmacokinetic parameters derived from these profiles were not significantly different between young subjects, elderly subjects and subjects with alcoholic liver disease. Individual plasma albumin concentrations provided a better index of the unbound plasma salicylate clearances and salicylate plasma protein binding than the age of the subject or the presence of alcoholic liver disease. Highest unbound plasma salicylate concentrations were found in subjects with the lowest plasma albumin concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543800
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  • 5
    Electronic Resource
    Electronic Resource
    PHARMACOKINETICS OF AN OSMOTICALLY CONTROLLED DELIVERY INDOMETHACIN PREPARATION IN NORMAL VOLUNTEERS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 10 (1983), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Indomethacin is still used commonly for the treatment of rheumatic diseases but is associated with side effects, particularly headache, in a number of patients. A controlled or sustained release formulation of indomethacin might provide lower peak plasma levels and thus reduce side effects while still maintaining adequate plasma levels to control pain and inflammation.In this single dose crossover study, normal volunteers received the new formulation of indomethacin (Indocid GITS 6/85) fasting or with a standard meal, indomethacin 75 mg with a standard meal or indomethacin 25 mg three times daily with a standard meal.Plasma concentration data showed that peak plasma levels were reduced but the area under the plasma concentration curve was not significantly different between the four treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1983.tb00845.x
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  • 6
    Electronic Resource
    Electronic Resource
    THE ACTION OF ASPIRIN ON PLASMA KININOGEN AND OTHER PLASMA PROTEINS IN RHEUMATOID PATIENTS: RELATIONSHIP TO DISEASE ACTIVITY (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 7 (1980), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their mean plasma kininogen level, 9.2 ± 0.7 μg bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 ± 0.5 μg/ml).2. When the rheumatoid patients received aspirin therapy for 1 week, their mean plasma kininogen concentration fell by 31% to 6.3 ± 0.8 μg Bk eq/ml. This was accompanied by a 20.4% fall in mean plasma α2-globuKn level. Haematocrit and total plasma protein were not significantly altered (P 〉 0.05).3. The fall in kininogen was very rapid, the main reduction occurring within the first hour.4. Aspirin therapy greatly reduced the pain assessments but had no effect on plasma concentrations of IgG, IgA, IgM, complement component C3, nor on ESR, haemoglobin, leucocyte count, nor ring size. Left hand grip strength was increased while right hand grip strength was unchanged.5. The action of aspirin on plasma kininogen and α2-globulin was similar to that of indomethacin. Plasma kininogen has been considered to be an acute phase reactant. The possible diagnostic value of plasma kininogen estimation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1980.tb00082.x
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  • 7
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    Unknown
    Earlier Greek (1926)
    St. Louis : Periodicals Archive Online (PAO)
    The Classical Bulletin. 3 (1926:Oct.-1927:Aug.) 20 
    Details
    ISSN: 0009-8337
    Topics: Classical Studies
    Notes: Communications
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3079-1926-003-00-000028
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  • 8
    Electronic Resource
    Electronic Resource
    d-Penicillamine metabolism in anin-vivo model of inflamed synovium (1988)
    Springer
    Inflammation research 25 (1988), S. 336-343 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Oxidation to disulphides is the chief metabolic transformation ofd-penicillamine (d-pen) in patients with rheumatoid arthritis. Oxidation also occurs in many biological fluidsin-vitro. Reduction of oxygen species may accompany the oxidation ofd-pen under appropriate conditions and may mediate the anti-rheumatic action ofd-pen. The transformation ofd-pen therefore was examined in anin-vivo model of inflamed synovium. Subcutaneous air-pouches of groups of rats were treated with saline, 10% serum or 10% zymosan activated serum (ZAS). The transformation ofd-pen to low molecular weight (LMW) metabolites and protein conjugates within the pouch was then assessed. The concentrations of total protein were significantly higher in the serum and ZAS-treated groups than in the saline-treated group and the inflammatory cell counts were significantly higher in the ZAS-treated group than in either of the other groups, as expected.d-pen oxidised rapidly to LMW metabolites and smaller amounts ofd-pen-protein conjugate (d-pen-protein) in the air pouches of all animals. The rates of oxidation to LMW metabolites were greater in the ZAS-treated animals than the saline-treated group (p〈0.005). The concentrations ofd-pen-protein conjugate were also greater for the serum-treated and ZAS-treated animals than for the saline controls (p〈0.005 in each case) at all times. Oxidation ofd-pen therefore occurs at this site of inflammation and is influenced by local conditions. This may be important to understanding the forms in whichd-pen exists in inflamed synovial joints and the way it may exert its antirheumatic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965040
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  • 9
    Electronic Resource
    Electronic Resource
    Biodistribution of64Cu in inflamed rats following administration of two anti-inflammatory copper complexes (1985)
    Springer
    Inflammation research 17 (1985), S. 104-111 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 64Cu was administered in two anti-inflammatory formulations to normal rats and to rats with 2 forms of local inflammation, namely (a) an acute paw oedema (elicited with carrageenan) or (b) a chronic granulomatous response to an implanted irritant (Mycobacterium tuberculosis in a polyurethane sponge). The copper formulations used were (i) a slow release one consisting of Cu(II) salicylate applied dermally with ethanol/DMSO and (ii) short acting hydrophilic complex (Cu(I)Cu(II)-penicillamine)5− given subcutaneously. Three types of changes in copper biodistribution with these forms of inflammation were discerned based on determination of64Cu and copper content in the following organs: inflammatory locus (foot or sponge implant), kidney, liver, spleen, adrenals, brain, blood, thymus, heart, and skin (site of application). The most evident changes were in the kidneys, liver, spleen, adrenals, thymus and serum from animals with chronic granulomatous inflammation. In contrast, a short term acute inflammatory stress (carrageenan paw oedema) had little effect. While copperd-penicillamine (applied subcutaneously) appeared to move as a bolus through the animals, the results with the percutaneous copper salicylate formulation are consistent with it providing a slow release source of copper(II). Exogenous64Cu from both formulations was sequestered at inflammatory sites (relative to serum). This may partly explain how applied copper complexes can be anti-inflammatory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966692
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  • 10
    Electronic Resource
    Electronic Resource
    Clinical pharmacology of GP53,633—a new non-steroidal anti-inflammatory drug — in patients with rheumatoid arthritis (1984)
    Springer
    Inflammation research 15 (1984), S. 424-427 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it to be rapidly absorbed with a short half life (approximately 2 hours). No change in pharmacokinetics is seen over a two week treatment period. Clinical parameters of inflammation were reduced and no adverse reactions were seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972382
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