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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 51 (1929), S. 462-471 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 6 (1976), S. 147-153 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma kininogen levels in the peripheral venous blood of untreated patients with active rheumatoid disease was found to be more than twice the levels measured in healthy normal individuals or in convalescing uncomplicated fracture patients. Treatment with oral indomethacin or aspirin lowered the kininogen levels nearly to normal. Sequential studies showed that the fall in kiniogen was very rapid, occurring within 1–2 hours of ingestion of drug, and was parallelled by reduction in the clinical indices of inflammation. Control studies showed that the kininogen changes were not due to changes in plasma volume or non-specific changes in plasma protein concentration. Indomethacin treatment had no effect on plasma kininogen levels in healthy volunteers. The significance of this finding will be discussed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 7 (1980), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their mean plasma kininogen level, 9.2 ± 0.7 μg bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 ± 0.5 μg/ml).2. When the rheumatoid patients received aspirin therapy for 1 week, their mean plasma kininogen concentration fell by 31% to 6.3 ± 0.8 μg Bk eq/ml. This was accompanied by a 20.4% fall in mean plasma α2-globuKn level. Haematocrit and total plasma protein were not significantly altered (P 〉 0.05).3. The fall in kininogen was very rapid, the main reduction occurring within the first hour.4. Aspirin therapy greatly reduced the pain assessments but had no effect on plasma concentrations of IgG, IgA, IgM, complement component C3, nor on ESR, haemoglobin, leucocyte count, nor ring size. Left hand grip strength was increased while right hand grip strength was unchanged.5. The action of aspirin on plasma kininogen and α2-globulin was similar to that of indomethacin. Plasma kininogen has been considered to be an acute phase reactant. The possible diagnostic value of plasma kininogen estimation is discussed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 14 (1984), S. 200-205 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 44 (1984), S. 269-302 
    ISSN: 1573-2878
    Keywords: Ocean test structures ; offshore structures ; wave kinematics ; identification problems ; parameter identification problems ; wave parameter identification problems ; numerical methods ; computing methods ; mathematical programming ; minimization of functions ; quadratic functions ; linear equations ; least-square problems ; global or strong accuracy ; local or weak accuracy ; integral accuracy ; condition number
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper deals with the solution of the wave parameter identification problem for ocean test structure data. A continuous formulation is assumed. An ocean test structure is considered, and wave elevation and velocities are assumed to be measured with a number of sensors. Within the frame of linear wave theory, a Fourier series model is chosen for the wave elevation and velocities. Then, the following problem is posed: Find the amplitudes of the various wave components of specified frequency and direction, so that the assumed model of wave elevation and velocities provides the best fit to the measured data. Here, the term best fit is employed in the least-square sense over a given time interval. At each time instant, the wave representation involves three indexes (frequency, direction, instrument); hence, three-dimensional arrays are required. This formal difficulty can be avoided by switching to an alternative representation involving only two indexes (frequency-direction, instrument); hence, standard vector-matrix notation can be used. Within this frame, optimality conditions are derived for the amplitudes of the assumed wave model. Numerical results are presented. The effect of various system parameters (number of frequencies, number of directions, sampling time, number of sensors, and location of sensors) is investigated in connection with global or strong accuracy, local or weak accuracy, integral accuracy, and condition number of the system matrix. From the numerical experiments, it appears that the identification problem has a unique solution if the number of directions is smaller than or equal to the number of sensors; it has an infinite number of solutions otherwise. In the case where a unique solution exists, the condition number of the system matrix increases as the size of the system increases, and this has a detrimental effect on the accuracy. However, the accuracy can be improved by proper selection of the sampling time and by proper choice of the number and location of the sensors.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 44 (1984), S. 453-484 
    ISSN: 1573-2878
    Keywords: Ocean test structures ; offshore structures ; wave kinematics ; identification problems ; parameter identification problems ; wave parameter identification problems ; numerical methods ; computing methods ; mathematical programming ; minimization of functions ; quadratic functions ; linear equations ; least-square problems ; Householder transformation ; global or strong accuracy ; local or weak accuracy ; integral accuracy ; condition number
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper deals with the solution of the wave parameter identification problem for ocean test structure data. A discrete formulation is assumed. An ocean test structure is considered, and wave elevation and velocities are assumed to be measured with a number of sensors. Within the frame of linear wave theory, a Fourier series model is chosen for the wave elevation and velocities. Then, the following problem is posed: Find the amplitudes of the various wave components of specified frequency and direction, so that the assumed model of wave elevation and velocities provides the best fit to the measured data. Here, the term best fit is employed in the least-square sense over a given time interval. At each time instant, the wave representation involves four indexes (frequency, direction, instrument, time); hence, four-dimensional arrays are required. This formal difficulty can be avoided by switching to an alternative representation involving only two indexes (frequency-direction, instrument-time); hence, standard vector-matrix notation can be used. Within this frame, optimality conditions are derived for the amplitudes of the assumed wave model. A characteristic of the wave parameter identification problem is that the condition number of the system matrix can be large. Therefore, the numerical solution is not an easy task and special procedures must be employed. Specifically, Gaussian elimination is avoided and advantageous use is made of the Householder transformation, in the light of the least-square nature of the problem and the discretized approach to the problem. Numerical results are presented. The effect of various system parameters (number of frequencies, number of directions, sampling time, number of sensors, and location of sensors) is investigated in connection with global or strong accuracy, local or weak accuracy, integral accuracy, and condition number of the system matrix. From the numerical experiments, it appears that the wave parameter identification problem has a unique solution if the number of directions is smaller than or equal to the number of sensors; it has an infinite number of solutions otherwise. In the case where a unique solution exists, the condition number of the system matrix increases as the size of the system increases, and this has a detrimental effect on the accuracy. However, the accuracy can be improved by proper selection of the sampling time and by proper choice of the number and location of the sensors. Generally speaking, the computations done for the discrete case exhibit better accuracy than the computations done for the continuous case (Ref. 5). This improved accuracy is a direct consequence of having used advantageously the Householder transformation and is obtained at the expense of increased memory requirements and increased CPU time.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 214 (1966), S. 223-233 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The dissolution of UO2 in carbonate-bicarbonate solutions containing sodium hypochlorite as an oxidant has been investigated. The effect of temperature, sodium hypochlorite concentration and stirring speed was examined. In the temperature range of 303 to 318 K, the leaching reaction displayed linear kinetics. Apparent activation energy obtained from the differential approach was found to be 57 kJ mol−1. This relatively high activation energy value indicates a chemically controlled behavior of UO2 dissolution. The order of reaction with respect to sodium hypochlorite concentration was found to be unity.
    Type of Medium: Electronic Resource
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