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  • 1
    Electronic Resource
    Electronic Resource
    Palliative care dentistry (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Gerodontology 17 (2000), S. 0 
    Details
    ISSN: 1741-2358
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The importance of dental care is often overlooked due to the omission of the dentist as a member of the palliative care team. However, many terminal patients exhibit oral difficulties that affect their quality of life. Palliative care dentists must exhibit empathy and compassion, and must be excellent communicators Dentists can play an important role in alleviating both the physical and psychological pain of dying. This paper describes the role of dentistry in palliative care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1741-2358.2000.00049.x
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  • 2
    Electronic Resource
    Electronic Resource
    Optimizing a mine haul truck wheel motors' condition monitoring program Use of proportional hazards modeling (2001)
    Bingley : Emerald
    Journal of quality in maintenance engineering 7 (2001), S. 286-302 
    Details
    ISSN: 1355-2511
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Technology , Economics
    Notes: Discusses work completed at Cardinal River Coals in Canada to improve the existing oil analysis condition monitoring program being undertaken for wheel motors. Oil analysis results from a fleet of 55 haul truck wheel motors were analyzed along with their respective failures and repairs over a nine-year period. Detailed data cleaning procedures were applied to prepare data for modeling. In addition, definitions of failure and suspension were clarified depending on equipment condition at replacement. Using the proportional hazards model approach, the key condition variables relating to failures were found from among the 19 elements monitored, plus sediment and viscosity. Those key variables were then incorporated into a decision model that provided an unambiguous and optimal recommendation on whether to continue operating a wheel motor or to remove it for overhaul on the basis of data obtained from an oil sample. Wheel motor failure implied extensive planetary gear or sun gear damage necessitating the replacement of one or more major internal components in a general overhaul. The decision model, when triggered by incoming data, provided both a recommendation based on an optimal decision policy as well as an estimate of the unit's remaining useful life. By optimizing the times of repair as a function both of age and condition data a 20-30 percent potential savings in overhaul costs over existing practice was identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/EUM0000000006007
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Insulin sensitizing agents may be useful in treatment of non-alcoholic fatty liver disease.Aim : A pilot study to evaluate the efficacy and safety of metformin in non-alcoholic fatty liver disease.Methods : In an open labelled study, patients with histologically confirmed non-alcoholic fatty liver disease were given metformin (20 mg/kg) for 1 year. Insulin resistance (by log homeostasis assessment model analysis for insulin resistance and Quantitative Insulin Sensitivity Check Index) and post-treatment hepatic histology were compared with pre-treatment histology.Results : Fifteen patients completed 1 year of treatment. During the initial 3 months, there was improvement in alanine aminotransferase and aspartate aminotransferase (P-value 0.01 and 0.02, respectively) along with improvement in insulin sensitivity. However, after 3 months, there was no further improvement in insulin sensitivity and there was gradual rise in aspartate aminotransferase and alanine aminotransferase back to pre-treatment levels. Among the 10 patients with post-treatment biopsy, three (33%), showed improvement in steatosis, two (20%) showed improvement in inflammation score and one (10%) showed improvement in fibrosis.Conclusion : Metformin treatment was associated with only a transient improvement in liver chemistries. A progressive, sustainable reduction in insulin sensitivity was not noted during treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02025.x
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  • 4
    Electronic Resource
    Electronic Resource
    Investment and employment in manufacturing in U.S. metropolitan areas 1960-1976
    Amsterdam : Elsevier
    Regional Science and Urban Economics 11 (1981), S. 431-469 
    Details
    ISSN: 0166-0462
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Architecture, Civil Engineering, Surveying , Geography , Sociology , Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0166-0462(81)90032-6
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  • 5
    Electronic Resource
    Electronic Resource
    Alterations in Functional Neuroanatomical Connectivity in Alzheimer's Disease (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Conscious recall of past events which have specific temporal and spatial contexts, termed episodic memory, is mediated by a system of interrelated brain regions. In Alzheimer's disease (AD) this system breaks down, resulting in an inability to recall events from the immediate past. Studies of normal human auditory-verbal short-term memory suggest that the brain system underlying these processes has distinct components, and the present study utilized the methods of functional brain mapping to determine the nature and extent of the breakdown that occurs in AD. Using subtraction techniques of PET-acquired images of regional cerebral blood flow we demonstrate that AD patients show a compensatory hyperactivation of various regions of cerebral cortex normally involved in these tasks, as well as activation of cortical areas not activated by normal elderly subjects. These results provide clear evidence of functional plasticity in the AD patient's brain even if those changes do not result in normal memory function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34425.x
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  • 6
    Electronic Resource
    Electronic Resource
    Our daily bread... (1988)
    [s.l.] : Nature Publishing Group
    Nature 331 (1988), S. 108-108 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] sir—The Committee on Medical Aspects of Food Policy of the Department of Health and Social Security has set up a panel to review the "recommended daily amounts" of food energy and nutrients for groups of people in the United Kingdom. The panel is concerned that its deliberations should ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/331108b0
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  • 7
    Electronic Resource
    Electronic Resource
    Kidney size and glomerular filtration rate in type 1 (insulin-dependent) diabetes mellitus revisited (1983)
    Springer
    Diabetologia 25 (1983), S. 530-530 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284465
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  • 8
    Electronic Resource
    Electronic Resource
    Glycaemia, arterial pressure and micro-albuminuria in Type 1 (insulin-dependent) diabetes mellitus (1984)
    Springer
    Diabetologia 26 (1984), S. 401-405 
    Details
    ISSN: 1432-0428
    Keywords: Plasma glucose ; urinary albumin excretion ; glycosylated haemoglobin ; blood pressure ; hypertension ; Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma glucose control and arterial pressure were assessed in 28 Type 1 (insulin-dependent) diabetic patients with different degrees of micro-albuminuria. They were divided into two groups according to their urinary albumin excretion rate: a low micro-albuminuria group (n= 16) with albumin excretion ranging between 12.1 and 28.9 μg/min and a high micro-albuminuria group (n= 12) with albumin excretion between 32.4 and 91.3 μg/min. The groups were matched for age, sex and duration of diabetes with the same number of normo-albuminuric (2.0–10.4 μg/min) diabetic control subjects. Both the low and high micro-albuminuria groups had significantly higher glycosylated haemoglobin levels and mean plasma glucose concentrations during a 24-h profile than their respective normo-albuminuric control subjects. A correlation between glycosylated haemoglobin level and urinary albumin excretion rate was found in the whole study group (r= 0.48; p〈 0.001). Arterial pressure (both systolic and diastolic) was significantly higher in the high micro-albuminuria group than in either the control group or the low microalbuminuria group. A significant correlation was found between arterial pressure and albumin excretion rate in the whole study population (r= 0.49; p〈 0.001) as well as in the pooled micro-albuminuria groups (r= 0.43; p〈 0.05). Multiple regression analysis showed that glycosylated haemoglobin and arterial pressure levels were independently correlated with albumin excretion rates. Diabetic patients with micro-albuminuria of any degree have worse glycaemic control than normo-albuminuric patients. Higher levels of arterial pressure, though often sub-hypertensive, are associated with levels of micro-albuminuria predictive of later development of clinical proteinuria. Thus high plasma glucose and high arterial pressure, or both, characterise those diabetic patients at increased risk of nephropathy. These indices of risk are potentially reversible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262209
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  • 9
    Electronic Resource
    Electronic Resource
    Changes in renal function in response to protein restricted diet in Type 1 (insulin-dependent) diabetic patients (1987)
    Springer
    Diabetologia 30 (1987), S. 154-159 
    Details
    ISSN: 1432-0428
    Keywords: Glomerular filtration rate ; albumin clearance ; dietary protein ; Type 1 (insulin-dependent) diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glomerular filtration rate, renal plasma flow and urinary albumin excretion rate were measured during insulin-induced euglycaemia in 12 male Type 1 (insulin-dependent) diabetic patients after a 3-week period of low protein diet (45 g/day) or a similar period on unchanged conventional diet (103 g/day). No changes in glycaemic control, indicated by home blood glucose profiles and serum fractosamine concentration, or in arterial pressure, were noted on either diet. On low protein diet, glomerular filtration rate was lower (p〈0.001) in all patients, but there was no difference in renal plasma flow between low protein diet and normal protein diet; filtration fraction fell significantly on low protein diet (p〈0.001). Fractional clearance of albumin was also lower (p〈0.05) on low protein diet. This study suggests that reduction of dietary protein induces, independently of changes in plasma glucose and arterial pressure, modifications in glomeralar filtration rate, filtration fraction and fractional clearance of albumin, which may be associated with a beneficial effect on the evolution of diabetic renal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274220
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  • 10
    Electronic Resource
    Electronic Resource
    The glomerular hyperfiltration of diabetes is not associated with elevated plasma levels of glucagon and growth hormone (1985)
    Springer
    Diabetologia 28 (1985), S. 718-721 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes ; glomerular filtration rate ; glucagon ; growth hormone ; plasma glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma concentrations of glucagon, growth hormone and glucose were measured hourly during an ordinary treatment day in 11 Type 1 (insulin-dependent) diabetic patients with high glomerular filtration rate, 11 Type 1 diabetic patients with normal glomerular filtration rate matched for age, diabetes duration and sex, and five healthy control subjects, simultaneously with the measurement of the glomerular filtration rate using 51Cr EDTA clearance. Plasma glucagon profiles were not statistically distinguishable (p = 0.49) from control values in either group, although they were somewhat lower in the hyperfiltering group. Plasma growth hormone values were higher than control (p=0.07) in both diabetic groups, but were not different between these two groups (p = 0.94). All indices of glycaemic control (glycosylated haemoglobin, urinary glucose excretion, and plasma glucose concentration) were higher in the hyperfiltering group, although no single index reached statistical significance. No correlations between concentrations of these substances and glomerular filtration rate were found. Elevated plasma concentrations of glucagon and growth hormone do not characterise those diabetic patients with high glomerular filtration rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265017
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