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  • 1
    Electronic Resource
    Electronic Resource
    The glomerular hyperfiltration of diabetes is not associated with elevated plasma levels of glucagon and growth hormone (1985)
    Springer
    Diabetologia 28 (1985), S. 718-721 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes ; glomerular filtration rate ; glucagon ; growth hormone ; plasma glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma concentrations of glucagon, growth hormone and glucose were measured hourly during an ordinary treatment day in 11 Type 1 (insulin-dependent) diabetic patients with high glomerular filtration rate, 11 Type 1 diabetic patients with normal glomerular filtration rate matched for age, diabetes duration and sex, and five healthy control subjects, simultaneously with the measurement of the glomerular filtration rate using 51Cr EDTA clearance. Plasma glucagon profiles were not statistically distinguishable (p = 0.49) from control values in either group, although they were somewhat lower in the hyperfiltering group. Plasma growth hormone values were higher than control (p=0.07) in both diabetic groups, but were not different between these two groups (p = 0.94). All indices of glycaemic control (glycosylated haemoglobin, urinary glucose excretion, and plasma glucose concentration) were higher in the hyperfiltering group, although no single index reached statistical significance. No correlations between concentrations of these substances and glomerular filtration rate were found. Elevated plasma concentrations of glucagon and growth hormone do not characterise those diabetic patients with high glomerular filtration rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265017
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  • 2
    Electronic Resource
    Electronic Resource
    Continuous subcutaneous insulin infusion does not induce a significant acute phase response of serum amyloid A protein (1985)
    Springer
    Diabetologia 28 (1985), S. 113-115 
    Details
    ISSN: 1432-0428
    Keywords: Continuous subcutaneous insulin infusion ; amyloidosis ; C-reactive protein ; acute phase response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a study of 23 matched pairs of Type 1 (insulin-dependent) diabetic patients receiving continuous subcutaneous insulin infusion or conventional insulin injection therapy respectively, there were no significant differences in serum levels of the acute phase proteins, serum amyloid A and C-reactive protein. These results do not support the suggestion that continuous subcutaneous insulin infusion stimulates serum amyloid A production or that it carries a risk of inducing reactive systemic amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279927
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Intralipid triglyceride and oral glucose tolerance (1974)
    Springer
    Diabetologia 10 (1974), S. 97-100 
    Details
    ISSN: 1432-0428
    Keywords: Triglycerides ; fat tolerance test ; oral glucose tolerance ; plasma insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inter-relation between hypertriglyceridaemia and glucose intolerance has been studied experimentally in fifteen male subjects by measuring the effect of acute elevation of plasma triglyceride (injection of Intralipid intravenously) upon oral glucose tolerance. The induced hypertriglyceridaemia did not alter the mean blood glucose or plasma insulin response to oral glucose. The associations between plasma triglyceride levels and glucose tolerance observed both in general population studies and in “patient” populations are probably due to a mutual link with a further factor or factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219663
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Increased glomerular permeability to albumin induced by exercise in diabetic subjects (1978)
    Springer
    Diabetologia 14 (1978), S. 293-300 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic nephropathy ; albumin ; β 2-microglobulin ; exercise ; hyperglycaemia ; microangiopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The urinary excretion of albumin was measured in insulin-dependent diabetics under ordinary conditions of life and in response to exercise. Possible mechanisms of exercise induced albuminuria in diabetics were also investigated. Under ordinary conditions of life the insulin-treated diabetics, as a group, had a higher mean urinary albumin excretion than normal controls; however, half of the diabetics had albumin excretion rates within the control range. A given exercise load (600 kpm/min for 20 min) produced an exaggerated albumin excretion in diabetics, particularly evident in the post-exercise period. The elevated urinary albumin excretion was due to an increased transglomerular passage of albumin, not to reduced tubular reabsorption. The increase was not associated with differences in blood pressure or urine flow between controls and diabetics. This exercise test has proved to be a suitable provocation test to unmask abnormalities in the glomerular handling of albumin that might not be recognisable at rest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01223019
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Continuous subcutaneous insulin Infusion: Good blood glucose control for up to 4 days (1979)
    Springer
    Diabetologia 16 (1979), S. 385-389 
    Details
    ISSN: 1432-0428
    Keywords: Subcutaneous insulin infusion ; near-normoglycaemia ; diabetic control ; open-loop device
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six insulin-dependent diabetics were studied on their conventional insulin treatment and during continuous, dual-rate, subcutaneous insulin infusion for periods of up to 4 days. Diabetic control, as assessed by mean plasma glucose, range of plasma glucose values, M-value or range of M-values was improved significantly in 5 patients (mean ± SD plasma glucose concentration on final infusion day 6.9±1.3 mmol/l, versus 11.3±3.2 mmol/l on conventional treatment). Once a suitable insulin dose was established blood glucose control could be maintained by continuous subcutaneous insulin infusion using the same daily infusion rate without frequent adjustment. In some cases this was less than the daily dose on the conventional treatment. However, glycaemic control in one “brittle” diabetic, with unpredictable swings in blood glucose on her normal regimen, was not improved by continuous subcutaneous insulin infusion. During the period tested there was no sepsis at the cannula implantation site and patients did not find the system uncomfortable or unduly inconvenient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01223159
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  • 6
    Electronic Resource
    Electronic Resource
    Worsening to diabetes in men with impaired glucose tolerance (“borderline diabetes”) (1979)
    Springer
    Diabetologia 16 (1979), S. 25-30 
    Details
    ISSN: 1432-0428
    Keywords: diabetes mellitus ; impaired glucose tolerance ; borderline diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two hundred and four men with impaired glucose tolerance (borderline diabetes) discovered in a screening examination have been observed for five years and repeated tests of glucose tolerance performed. By pre-determined criteria 27 men ‘worsened to diabetes’ and this metabolic deterioration was not significantly influenced by treatment with carbohydrate restriction with or without a daily dose of 50 mg phenformin. Of the baseline variables measured prior to treatment allocation only the blood glucose values were significantly predictive of ultimate worsening to diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00423146
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Kelly McGuffin West 1925–1980 (1980)
    Springer
    Diabetologia 19 (1980), S. 482-483 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00281830
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Continuous subcutaneous insulin infusion: A developing tool in diabetes research (1980)
    Springer
    Diabetologia 18 (1980), S. 1-4 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01228294
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  • 9
    Electronic Resource
    Electronic Resource
    The Bedford Survey: Ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics (1982)
    Springer
    Diabetologia 22 (1982), S. 79-84 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; impaired glucose tolerance ; coronary heart disease ; blood pressure ; cigarette smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mortality rates from coronary heart disease and from all causes have been ascertained over ten years in three groups of people participating in the Bedford Survey — newly-diagnosed diabetics, borderline diabetics and control subjects with normal glucose tolerance. Age corrected mortality rates, from all causes and coronary heart disease, were highest in the diabetics and intermediate in the borderline diabetics and in both groups were similar in men and women. When statistical allowance was made for baseline differences in age, blood pressure and obesity, female borderline diabetics still had a significantly increased risk over their controls of death from ‘all causes’. Much of the difference appeared to be due to a relative excess of deaths due to coronary heart disease. It is concluded that borderline diabetes (or impaired glucose tolerance) is associated with a relatively greater increase in mortality risk in women than men. During the 10-year follow-up of the Bedford borderline diabetics, coronary heart disease morbidity and mortality rates were similar in men and women. Age at entry to the study was the major independent and significant predictor of mortality from all causes. The level of systolic blood pressure and current cigarette smoking at baseline were statistically significant predictors only of mortality due to coronary heart disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254833
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  • 10
    Electronic Resource
    Electronic Resource
    Second Annual Meeting of the European Association for the Study of Diabetes abstracts (1966)
    Springer
    Diabetologia 2 (1966), S. 202-228 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01222072
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    Paper (German National Licenses)
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