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  • 1
    Electronic Resource
    Electronic Resource
    Bestimmung des Labeling-Index von HNO-Tumoren mit einem Antinukleosid-Antikörper (1981)
    Springer
    European archives of oto-rhino-laryngology and head & neck 231 (1981), S. 751-754 
    Details
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The proliferation rate of tumor cells is analysed by the proportion of cells in the S-phase of the cell cycle expressed as the labeling index. During DNA synthesis, regions of single-stranded DNA are exposed. As antinucleosid antibodies react specifically with single-stranded or denatured DNA, only the nuclei of cells in S-phase are immunreactive. Pretreatment with RNase avoids interference of unspecific RNA immunreactivity. The labeling index was determined in different head and neck cancer specimen by a bridge technique for antinucleosid antibody immunperoxidase or with a direct immunfluorescent staining. The rapid assessment of this immuno-chemical method in comparison to the conventional autoradiography seems to open a future application for determining the labeling index in the routine diagnosis in correlation to morphological structures of solid tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501730
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  • 2
    Electronic Resource
    Electronic Resource
    erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 150-153 
    Details
    ISSN: 1434-4726
    Keywords: Proto-oncogenes ; Gene amplification ; Overexpression ; Parotid gland tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proto-oncogenes represent a family of normal cellular genes that were identified on the basis of their similarity to genetic sequences with known tumorigenic + or transforming potential. Accumulating evidence links alterations in either the structure, copy number, or expression of one or another of these genes to neoplasia. One such gene, called erbB-2/Her-2 was found amplified in an adenocarcinoma of the human salivary gland and has also been found associated with primary human breast cancer. Patients with multiple copies of the gene have had a shorter overall survival. In the present study, 21 tumors of the parotid gland were examined by Southern and Northern blot hybridization for amplification and possible overexpression of the erbB-2/Her-2 oncogene. Normal parotid gland tissue was used as negative control. The parotid gland lesions comprised 7 pleomorphic adenomas, 5 squamous cell carcinomas, 4 cases of chronic fibrotic sialadenosis, 3 mucoepidermoid carcinomas as well as 1 lymphoma and 1 cystadenolymphoma. Gene amplification was found in 1 of the pleomorphic adenomas, with 2 tumors showing a significant overexpression of the erbB-2/Her-2 oncogene. Because 3–5% of all pleomorphic adenomas undergo malignant transformation, close follow-up of patients is currently underway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171701
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 277-280 
    Details
    ISSN: 1434-4726
    Keywords: Retinoblastoma ; Osteosarcoma ; Irradiation ; Anti-oncogenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB 1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed to disclose any structural aberration of the RBl gene. A somatic mutation (deletion) affecting the other allele was found in the osteosarcoma cells. Management of tumor by external radiotherapy in early age is questioned because the effect of irradiation is to significantly increase the total incidence of second tumors above the already high incidence in non-irradiated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186225
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  • 4
    Electronic Resource
    Electronic Resource
    Adenoma of the middle ear mucosa (1996)
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 65-68 
    Details
    ISSN: 1434-4726
    Keywords: Mucosal tumors ; Middle ear adenoma Histopathology ; Clinical features
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Benign adenomas of the middle ear are rare tumors. To date, approximately 100 cases of adenomatous neoplasms of the middle ear space have been collected in the United States Armed Forces Institute of Pathology, Washington D.C. This report describes two cases of primary adenomatous neoplasms confined to the middle ear cleft seen at the Department of Otorhinolaryngology at Ludwig Maximilians University Hospital, Munich. Although tumors are derived from lining epithelium of the middle ear mucosa, the unique feature of our first case was based on its origin in the epitympanic part of the tympanic membrane. Histopathology was characterized by an adenomatous morphology without atypia or mitoses, proving its benign behavior. No evidence was found for invasion of adjacent tissue. Simple surgical removal afforded excellent prognosis. Clinical behavior, histological appearance, origin of tumors and differential diagnosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176707
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    Paper (German National Licenses)
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