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  • 1
    Electronic Resource
    Electronic Resource
    Importance of Magnetic Resonance Imaging in the Conservative Management of Posterior Fossa Epidural Haematomas: Case Illustration (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 717-718 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010070120
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  • 2
    Electronic Resource
    Electronic Resource
    Neurogenic hypernatraemia (1979)
    Springer
    Acta neurochirurgica 46 (1979), S. 151-157 
    Details
    ISSN: 0942-0940
    Keywords: Neurogenic hypernatraemia ; craniopharyngioma ; ADH ; hypothalamic receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 49-year-old man was submitted to neurosurgery for a cranio-pharyngioma. The lesion, which appeared to involve the antero-inferior wall of the third ventricle, caused lack of appropriate antidiuretic hormone (ADH) release in response to hypernatraemia and plasma hyperosmolality. The probable mechanism of this hypothalamic syndrome is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407688
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  • 3
    Electronic Resource
    Electronic Resource
    Brain energy metabolism in the acute stage of experimental subarachnoid haemorrhage: Local changes in cerebral glucose utilization (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 737-744 
    Details
    ISSN: 0942-0940
    Keywords: Autoradiography ; cerebral metabolism ; rat ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An experimental model was used to investigate acute alterations of cerebral metabolic activity in rats subjected to subarachnoid haemorrhage (SAH). Haemorrhages were produced in anaesthetized animals by injecting 0.3 ml of autologous, arterial nonheparinized blood into the cisterna magna. Control rats received subarachnoid injections of mock-cerebrospinal fluid to study the effect of sudden raised intracranial pressure, or underwent sham operation. Three hours after SAH rats were given an intravenous injection of [14C]-2-deoxyglucose. Experiments were terminated by decapitation, and the brains were removed and frozen. Regional brain metabolic activity was studied by quantitative autoradiography. In comparison with sham-operated controls, cerebral metabolic activity was diffusely decreased after SAH. Statistically significant decreases in metabolic rate were observed in 23 of 27 brain regions studied. Subarachnoid injections of mock-cerebrospinal fluid also produced depression of cerebral metabolic activity, but quantitatively these changes were not as pronounced and diffuse as in SAH rats. The present study shows that a widespread depression of brain metabolism occurs in the acute stage after experimental SAH and is probably secondary to the Subarachnoid presence of blood itself and/or blood products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411481
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Time-Course of Blood-Brain Barrier Permeability Changes After Experimental Subarachnoid Haemorrhage (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 575-581 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Blood-brain barrier; evans blue; rat; subarachnoid haemorrhage.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ An increase in blood-brain barrier (BBB) permeability after subarachnoid haemorrhage (SAH) has been described in humans and has been correlated with delayed cerebral ischemia and poor clinical outcome. Few studies examined in the laboratory the relationship between SAH and BBB, with contrasting results due to limitations in experimental probes adopted and in timing of observation. The aim of this study was to quantify the time-course of BBB changes after experimental SAH. Groups of eight rats received injections of 400 μl of autologous arterial blood into the cisterna magna. BBB was assessed 6, 12, 24, 36, 48, 60, and 72 hours after SAH and in sham-operated animals separately for cerebral cortex, i.e. frontal, temporal, parietal, occipital, subcortical gray matter (Caudate-Putamen-Thalamus), cerebellar cortex and nuclei, and brain stem by a spectrophotofluorimetric evaluation of Evans Blue dye extravasation. As compared to sham-operated controls, SAH determined a significant BBB permeability change beginning 36 hours after SAH, peaking at 48 hours, and normalizing on day 3. This study provides a quantitative description of the temporal progression and recovery of BBB dysfunction after SAH. These results have implications for the management of aneurysm patients and for assessing the rationale and the therapeutic window of new pharmacological approaches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050472
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  • 5
    Electronic Resource
    Electronic Resource
    Treatment of benign intracranial hypertension (1980)
    Springer
    Acta neurochirurgica 51 (1980), S. 187-193 
    Details
    ISSN: 0942-0940
    Keywords: Benign intracranial hypertension ; ICP recording ; cerebral oedema ; arachnoid villi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study is based on 11 cases with pseudotumour cerebri. In each case a high dose of Escin was administered intravenously, and the drug effect during ICP recording was observed. In seven cases the drug manifested a significant hypotensive effect. In these cases the treatment with Escin (20 mg every 8 hours) was continued for 3 days; the control if ICP after this period showed a normal pressure in all cases. Oral treatment was continued at the same dosage for 20–30 days and the patient was then discharged. All patients presented complete remission of the clinical syndrome and fundus normalization. Follow-up after a year showed no recurrence. In three cases the treatment with Escin was unsuccessful; these patients were given dexamethasone, with normalization of the syndrome. Another case that presented with a severe picture of intracranial hypertension and visual impairment was treated with Escin and dexamethasone without positive result. The patient improved with external CSF drainage, and was treated by a shunt procedure that induced remission of the syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406744
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  • 6
    Electronic Resource
    Electronic Resource
    Autoradiographic assessment of pineal gland glucose utilization and capillary permeability in the unanesthetized rat (1990)
    Springer
    Child's nervous system 6 (1990), S. 222-224 
    Details
    ISSN: 1433-0350
    Keywords: Pineal gland ; Glucose metabolism ; Capillary permeability ; Quantitative autoradiography ; Positron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pineal gland glucose utilization (GU) and capillary permeability (CP) were measured in unanesthetized rats, using complementary quantitative autoradiographic techniques. GU values within the pineal tissue were homogeneously distributed around 70 μmol of glucose/100 g each min, i.e., they were approximately 30% lower than in the cortical gray structures. The blood-to-brain transfer constant of [14C]-α-aminoisobutyric acid, as an index of CP, was up to ten orders of magnitude higher than that for the rest of the brain. These measurements were carried out at that point in the circadian rhythm that corresponds to the minimum level of neurosecretory activity of the pineal gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01850978
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