ISSN:
1432-2307
Keywords:
Key words Hodgkin’s disease
;
Central nervous system
;
Proliferation
;
Apoptosis
;
bcl-2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 62-year-old woman presented with loss of memory and a mild hemiparesis. Neuroradiology demonstrated a left frontoparietal tumour. Biopsy specimens of this lesion revealed intracerebral Hodgkin’s lymphoma, a diagnosis supported by immunohistochemical reactions of the tumour cells for the CD30 antigen. Additional cell cycle studies revealed a high proliferative activity of the tumour cells in association with absence of apoptosis. There was no evidence that overexpression of bcl-2 or Epstein-Barr virus infection was involved in the pathogenesis of this neoplasm. Lymphomas in the lung were detected 3 months later. Following neurosurgical excision, radiotherapy, and chemotherapy, the patient had no evidence of Hodgkin’s disease after 13 months of follow-up.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004280050195
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