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  • 1
    Electronic Resource
    Electronic Resource
    Relative Importance of Somatodendritic and Terminal Dopaminergic Autoreceptors for the Effects Produced by Systemic (–)3-PPP Administration on Rat Locomotor Activity (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 604 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb32030.x
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  • 2
    Electronic Resource
    Electronic Resource
    Specific Involvement of Central 5-HT1A Receptors in the Mediation of Male Rat Ejaculatory Behavior (1997)
    Springer
    Neurochemical research 22 (1997), S. 1065-1070 
    Details
    ISSN: 1573-6903
    Keywords: Serotonin receptors ; sexual behavior ; ejaculation ; male rat ; review
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aminotetralin 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), pharmacologically characterized as a 5-HT1A receptor agonist, produces a pronounced decrease in ejaculation latency in the male rat. Stimulation of 5-HT receptors by a pharmacologically induced increase in the synaptic availability of 5-HT has been shown to produce the opposite effect. The 8-OH-DPAT-induced decrease in ejaculation latency is specific for this compound, and some chemically related ergot derivatives. In this paper we review the evidence in support for stimulation of serotonergic auto-receptors of the 5-HT1A receptor subtype as a mechanism of action for effects by 8-OH-DPAT on male rat ejaculatory behavior. We also present the questions posed by the fact that quinpirole and lisuride both produce 8-OH-DPAT-like effects on male rat ejaculatory behavior. The effects by quinpirole, lisuride or 8-OH-DPAT are not sensitive to pretreatment with the DA D2/3 receptor antagonist raclopride. Continued studies will show whether the effects of quinpirole and lisuride can be related to stimulation of 5-HT1A receptors, or if all these compounds have as yet undefined common properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022443413745
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence for the involvement of central 5-HT1A receptors in the mediation of lordosis behavior in the female rat (1989)
    Springer
    Psychopharmacology 98 (1989), S. 440-444 
    Details
    ISSN: 1432-2072
    Keywords: 5-HT receptors ; 5-HTP ; 8-OH-DPAT ; Lordosis ; Female rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 5-Hydroxy-L-tryptophan (5-HTP), 25 mg kg-1 IP, in combination with the peripheral 5-HTP decarboxylase inhibitor benserazide, 25 mg kg-1 IP, and the selective inhibitor of neuronal 5-hydroxytryptamine (5-HT) re-uptake, zimeldine, 10 mg kg-1 IP, suppressed lordosis in ovariectomized female rats, treated with estradiol benzoate (EB) or with EB plus progesterone (P). The suppression of lordosis produced by 5-HTP was antagonized by the β-receptor blocker (-)pindolol, which also is a selective 5-HT1 receptor antagonist, but not by the 5-HT2 receptor antagonists metitepine or pirenperone, nor by the β-receptor blocker betaxolol. The EB-or EB plus P-activated lordosis was also suppressed by administration of the selective 5-HT1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Together, these observations indicate an important role of central 5-HT1a receptors in the mediation of lordosis behavior in the female rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441938
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat (1989)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 339 (1989), S. 551-556 
    Details
    ISSN: 1432-1912
    Keywords: Dopamine ; 5-HT synthesis ; Brain ; 8-OHDPAT ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Regional dopamine synthesis in the rat striatum was estimated by measuring DOPA accumulation following inhibition of cerebral aromatic l-amino acid decarboxylase by means of NSD-1015, 100 mg kg−1 intraperitoneally. In animals treated with reserpine, 5 mg kg−1 subcutaneously −18 h, there was a statistically significant increase in DOPA accumulation in the nucleus accumbens, the ventro-medial neostriatum, the dorso-lateral neostriatum and in the posterior limb of the neostriatum. This increase in DOPA accumulation was antagonized dose-dependently in the nucleus accumbens and ventro-medial neostriatum, but not in the other two regions, by treatment with the 5-HT1A receptor agonist 8-OH-DPAT, 0.15–2.4 μmol kg−1, whereas the partial dopamine D2 receptor agonist (−)3-PPP, 2.5–10.0 μmol kg−1, or the full dopamine D2 receptor agonist quinpirole, 0.05–0.8 μmol kg−, antagonized the reserpine-induced increase in DOPA accumulation uniformly in all four regions of the striatum. The suppression of DOPA accumulation by 8-OH-DPAT in reserpine-treated animals, was completely antagonized by raclopride, 1 μmol kg−1, but not by (−)pindolol, 8 μmol kg−1. The accumulation of 5-HTP in all regions of the striatum as well as in the neocortex following decarboxylase inhibition and reserpine pretreatment, was also inhibited by 8-OH-DPAT, and this inhibition was unaffected by treatment with raclopride or (−)pindolol. It is concluded that 8-OH-DPAT, in addition to general effects on forebrain 5-hydroxytryptamine synthesis, selectively affects limbic forebrain dopamine synthesis. This latter effect is probably due to direct stimulation of dopamine autoreceptors, since it was obtained in reserpine-treated rats, and was completely antagonized by raclopride, but not (−)pindolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167260
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  • 5
    Electronic Resource
    Electronic Resource
    Stimulation of forward locomotion by SCH-23390 and raclopride in d-amphetamine-treated rats (1998)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 357 (1998), S. 593-599 
    Details
    ISSN: 1432-1912
    Keywords: Key words d-amphetamine ; Dopamine receptors ; Locomotor activity ; Raclopride ; SCH-23390 ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In d-amphetamine-treated (4.0 mg kg–1 s.c.) rats the selective dopamine D1 and D2/3 receptor antagonists SCH-23390 (2.5–20.0 µg kg–1 s.c.) and raclopride (12.5–100.0 µg kg–1 s.c.), respectively, produced a biphasic pattern of effects on forward locomotion, as observed in an open-field arena (≈0.5 m2). Thus, at the low doses of SCH-23390 (2.5–10.0 µg kg–1) or raclopride (12.5–50.0 µg kg–1), there was a statistically significant increase in forward locomotion, followed by suppression of the behavior at the higher doses. The SCH-23390-induced (5.0 µg kg–1) stimulation of forward locomotion was partially antagonized by concomitant raclopride treatment (12.5–25.0 µg kg–1) and the corresponding raclopride-induced (12.5 µg kg–1) stimulation was fully antagonized by treatment with SCH-23390 (2.5–5.0 µg kg–1). Furthermore, the SCH-23390- or raclopride-induced stimulation of forward locomotion was also antagonized by treatment with the α1-adrenoceptor antagonist prazosin (1.0 mg kg–1 s.c.). These observations suggest that under conditions of an increased general tone at brain dopamine receptors, there is a mutual inhibitory synergy between dopamine D1 and D2/3 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005213
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  • 6
    Electronic Resource
    Electronic Resource
    Behavioural and biochemical effects of L-DOPA after inhibition of dopamine-Β-hydroxylase in reserpine pretreated rats (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 270 (1971), S. 349-360 
    Details
    ISSN: 1432-1912
    Keywords: L-DOPA ; Dopamine-Β-Hydroxylase Inhibition ; Reserpine ; Conditioned Avoidance Response ; Monoamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A single dose of L-3,4-dihydroxyphenylalanine (l-DOPA, 100 mg/kg i.p.), after peripheral DOPA-decarboxylase inhibition by means of N1-(DL-seryl)-N2-(2,3,4-trihydroxybenzyl) hydrazine (Ro 4-4602, 50 mg/kg i.p.) given to reserpinepretreated (5 mg/kg i.p.) male rats, was found to reverse the reserpine-induced suppression of a conditioned avoidance response (CAR). This reversal followed the same time course as the increase in central dopamine (DA) levels, whereas the small but significant increase in central noradrenaline (NA) levels had a longer duration than the CAR reversal. When L-DOPA was given to rats pretreated with reserpine and bis-(4-metliyl-l-homopiperazinylthiocarbonyl)disulfide (FLA-63, 10 mg/kg i.p.), a DA-Β-hydroxylase inhibitor, the accumulation of NA was inhibited and the CAR reversal was markedly reduced. Animals treated with FLA-63 in addition to reserpine displayed a more stereotyped behaviour after L-DOPA than those not treated with FLA-63 and it is suggested that NA has a moderating influence on sterotyped behaviour. The results obtained in the current investigation provide further support for the view that the loss of CA, especially, DA, is of importance for the gross behavioural syndrome observed after reserpine. It is suggested that DA is important for elementary motor functions (e.g. locomotor activity) whilst additional NA receptor stimulation is essential for more complex and integrated behaviour (e.g. a conditioned avoidance response).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002347
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  • 7
    Electronic Resource
    Electronic Resource
    Learning deficits in 4 weeks old offspring of the nursing mothers treated with the neuroleptic drug penfluridol (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 31-37 
    Details
    ISSN: 1432-1912
    Keywords: Conditioned Avoidance Response ; Learning ; Development ; Penfluridol ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The acquisition of a conditioned avoidance response (CAR) was investigated in rats of nursing mothers given penfluridol 1.0 mg/kg on days 1, 3 and 5 after delivery. The male litter-mates were tested for CAR acquisition 4 weeks after birth. The animals whose mothers had received penfluridol were markedly inferior in the CAR acquisition than rats of mothers given glucose. Furthermore, rats of penfluridol-treated mothers were found to be heavier than those of glucose-treated mothers when weighed at 8 weeks of age. However, there was no difference between the groups at 4 weeks of age. The possibility that penfluridol interacts with the development of catecholamine mechanisms in the brain at a sensitive developmental period, and thereby influences later performance, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502065
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  • 8
    Electronic Resource
    Electronic Resource
    The effect of chronic ethanol treatment on behaviour and central monoamines in the rat (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 300 (1977), S. 205-216 
    Details
    ISSN: 1432-1912
    Keywords: Chronic ethanol treatment ; Rat ; Behaviour ; Central monoamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats weaned at 16 days of age were treated with various ethanol concentrations (8–24% w/v) for 270 days. The effect of the chronic ethanol treatment on the growth rate, the diurnal pattern of drinking, the open field activity, and the conditioned avoidance acquisition and retention of the rats were studied. Termination of the chronic ethanol administration caused two types of withdrawal syndromes. The first, an acute withdrawal syndrome was observed within 12 h after the discontinuation of the ethanol treatment and was characterized by extreme hyperexcitability. The second, a delayed withdrawal syndrome was characterized by a more coordinated behavioural stimulation and developed first after about 3 days after the discontinuation of the ethanol treatment. Biochemically, the latter withdrawal syndrome was accompanied by an increased rate of tyrosine hydroxylation (measured as the accumulation of dopa after inhibition of aromatic amino acid decarboxylase) in the striatum and dopamine-rich limbic structures. No differences in the accumulation of 5-hydroxytryptophan were observed. Furthermore, there was an increased level of dopamine concomitant with a decreased level of noradrenaline in the limbic areas during ongoing ethanol treatment. On the 4th day after withdrawal of ethanol the endogenous levels of dopamine and noradrenaline were statistically significantly reduced in the limbic structures. The data of the present study indicate that chronic ethanol administration induces various kinds of behavioural changes and that these changes at least partially are mediated via central catecholamine mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500962
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of the local application of 3-PPP and sulpiride enantiomers into the nucleus accumbens or into the ventral tegmental area on rat locomotor activity: evidence for the functional importance of somatodendritic autoreceptors (1992)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 345 (1992), S. 516-522 
    Details
    ISSN: 1432-1912
    Keywords: 3-PPP ; Sulpiride ; Enantiomers ; Dopamine ; Autoreceptors ; Localization ; Locomotor activity ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present series of experiments was performed in order to determine the relative role of presynaptic and somato-dendritic autoreceptors for the sedative effects produced by systemically administered dopaminergic agonists. Thus, the effects of intracerebral administration of 3-(3-hydroxyphenyl)-N-n-propylpip-eridine (3-PPP), or sulpiride, enantiomers on spontaneous locomotor activity was investigated in rats. It was found that the local application of (−)3-PPP, but not (+)3-PPP, into the nucleus accumbens (1.25–80.0 μg, bilaterally) produced a suppression of the locomotor activity, whereas the local application of the two enantiomers into the ventral tegmental area resulted in a suppression of the locomotor activity in the same dose range. Thus, the full dopamine D2 agonist (+)3-PPP produced suppression of locomotor activity only after local application into the somato-dendritic region, suggesting that in terminal areas postsynaptic receptor stimulation effectively counterbalanced the functional consequences of presynaptic receptor stimulation. The sulpiride enantiomers both produced a suppression of locomotor activity after local application into the accumbens (0.2-5.0 μg, bilaterally). In the ventral tegmental area, however, (−)sulpiride administration (0.25.0 μg, bilaterally) resulted in an increased locomotion, whereas the (+)enantiomer produced no effect or, at the highest dose (5.0 μg), a suppression of the locomotor activity. These observations indicate that for a dopamine D2 antagonist, the postsynaptic receptor blockade in the terminal region, resulting in behavioral suppression, not only counteract compensatory effects produced via the presynaptic receptor in this region, but also to a great extent overshadow the functional consequences of somatodendritic autoreceptor blockade. The results also demonstrate that the dopamine receptor agonist [(+)3PPP], a partial agonist [(−)3-PPP] and an antagonist [(−)sulpiride], each produce distinct functional effects when considering their effects at postsynaptic dopamine receptors in projection areas of the ventral striatum together with their effects at dopamine autoreceptors in the cell body region of the ventral tegmental area. It is concluded that autoreceptor-mediated sedative effects of dopamine receptor agonists, as observed upon systemic administration in the normal animal, primarily are mediated via dopamine autoreceptors in the cell body region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168942
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  • 10
    Electronic Resource
    Electronic Resource
    Potency mismatch for behavioral and biochemical effects by dopamine receptor antagonists: implications for the mechanism of action of clozapine (1993)
    Springer
    Psychopharmacology 110 (1993), S. 273-279 
    Details
    ISSN: 1432-2072
    Keywords: Monoamines ; Behavior ; Clozapine ; Raclopride ; SCH-23390 ; Conditioned avoidance response ; Dopamine synthesis ; Dopamine receptor subtypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clozapine (3.8–60.0 µmol kg−1) did not produce any alterations in DOPA accumulation (following inhibition of cerebral aromaticl-amino acid decarboxylase) in the prefrontal cortex or in three regions of the neostriatum, i.e. the ventral, the dorso-lateral and the posterior regions, in the rat. In contrast, clozapine produced a reduction in the 5-HTP accumulation in all these brain areas, except for the prefrontal cortex. Raclopride (0.08–20.0 µmol kg−1) produced a marked increase in DOPA accumulation in all four brain regions and an increase in 5-HTP accumulation in the dorso-lateral neostriatum (2.5–20.0 µmol kg−1), but not in the other forebrain regions. Treatment with SCH-23390 (0.4–1.6 µmol kg−1) resulted in increased DOPA accumulation in the ventral and posterior parts of the neostriatum. No other changes in the DOPA or 5-HTP accumulation were seen with SCH-23390. Considering the doses of these three compounds needed for suppression of conditioned avoidance behavior and for the induction of cataleptic rigidity, it is concluded that raclopride produces an increased DA synthesis at much lower doses than those needed for behavioral effects. In contrast, the behavioral effects of SCH-23390 or clozapine precedes effects on brain DA synthesis on the dose-effect curve. In fact, the only biochemical effect of clozapine, which was observed in low, yet behaviorally active doses, was a decrease in forebrain 5-HTP accumulation. In conclusion, the present results demonstrate a mismatch, in different directions for raclopride and SCH-23390, as regards the doses needed to produce effects on brain dopamine synthesis and on behavior. Thus, the biochemical effects are seen with lower doses than the behavioral effects for the DA D2 receptor blocking agent, whereas the opposite relationship is the case for the DA D1 receptor antagonist. Taking these two DA receptor subtypes into consideration, the possibility should be considered that clozapine produces its antipsychotic-like behavioral effects on animal behavior primarily by a blockade of brain DA D1, rather than D2, receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02251281
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