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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 657-659 
    Details
    ISSN: 1432-1041
    Keywords: Temocapril, Renal insufficiency ; angiotensin-I converting enzyme inhibitor, pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of temocapril hydrochloride, a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, has been studied in patients with mild (Group II) to severe (Group III) renal insufficiency in comparison with subjects with normal renal function (Group I). The pharmacokinetic parameters of the active diacid metabolite, including Cmax, AUC and half-life (t1/2), showed only slight changes between the three groups: AUC (0–∞) was significantly larger in Group III than Group I, and t1/2 tended to be prolonged in Group III, but the change was not significant. The urinary recovery of the diacid was significantly decreased in Group III. (Group I, 28.1 %, Group II, 21.6 %, Group III, 12.8 %). Compared with other ACE inhibitors, which are mainly excreted through the kidney, the plasma concentration of the active diacid metabolite was hardly influenced by renal function. It was speculated that lowering of the dose of temocapril might be recommended only in patients with severe renal insufficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284968
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  • 2
    Electronic Resource
    Electronic Resource
    High resolution threshold photoelectron spectrum of oxygen in the 12–19 eV region (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 4875-4880 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The threshold photoelectron spectrum of oxygen has been measured with high resolution in the photon energy range of 12–19 eV using a penetrating field technique and a synchrotron radiation source. The long vibrational progression of the X2Πg state of O2+ was observed to v′=45. An extrapolation in a Birge–Sponer plot (ΔG versus v′+1/2) gives a maximum vibrational level vmax′=56. The A2Πu state was also measured in detail. Most vibrational levels of the A2Πu state of O2+ (from v′=0 to 24) were observed for the first time. A Birge–Sponer plot of the A2Πu state gives a maximum vibrational level vmax′=31. The dissociation limit of the A2Πu state is slightly higher (76 meV) than the well-known dissociation limit O(3P2)+O+(3S0) 18.733 eV. Therefore the A2Πu state may be considered to have a hump. We observed new states which were assigned to 4Σg+ and 2Σu+ according to a previous theoretical investigation [Beebe et al., J. Chem. Phys. 64, 2080 (1976)]. Potential curves of the X2Πg and A2Πu states were calculated by the Rydberg–Klein–Rees method using both the rotational constants obtained previously by others [K. P. Huber and G. Herzberg, Molecular Spectra and Molecular Structure, Constants of Diatomic Molecules Volume IV (Van Nostrand, New York, 1974)] and the vibrational energy values observed in the present experiment. A Le Roy–Bernstein plot as well as a Birge–Sponer plot were used to determine the dissociation energy of the X2Πg state. However, the plot gave an unreasonably large dissociation limit. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.474849
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of maternal lifestyle on cord blood IgE factor (1997)
    Springer
    European journal of epidemiology 13 (1997), S. 395-402 
    Details
    ISSN: 1573-7284
    Keywords: Cord blood IgE ; Intrauterine sensitization ; Lifestyle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During recent decades much interest has been focused on the possibility of predicting and preventing atopic diseases during pregnancy. The idea of being able to detect a predisposition early and take suitable environmental measures in order to avoid overt allergy is an attractive position. Elevated cord IgE of around 1.0 IU/ml has been proposed as a predictor in western children. However, there remains no information about the effect of maternal lifestyle during pregnancy on these levels. Total IgE levels were therefore determined using Pharmacia CAP system and PRIST, with sensitivities of 0.01 kU/l and 0.25 kU/l, respectively, from serum samples taken from 1138 Japanese pairs of cord blood and pregnant women responding to a questionnaire regarding 17 health practices, intake of 32 food allergens and 5 environmental factors. Of these, 28 (2.5%) pairs of samples were excluded from further analysis because of high contamination of IgA (〉 15.4 mg/ml) in cord blood. Median cord blood IgE was 0.286 kU/l and geometric mean IgE was 66.25 kU/l in maternal sera using CAP system; there was no significant correlation between maternal log (IgE) and cord blood IgE. Similar results were obtained from PRIST, whose correlation with CAP system was significant (r = 0.884, p 〈 0.001 for maternal and r = 0.765, p 〈 0.001 for cord blood). Multiple logistic analysis demonstrated that avoidance of simultaneous exposure to hens' eggs and cow's milk (relative risk = 1.3, p 〈 0.05) as well as soy beans (relative risk = 2.8, p 〈 0.01) should be advised to mothers with positive allergic histories and/or high total IgE (〉 400 IU/ml), especially in women aged more than 35 years who are pregnant with a male child. However, maintenance of healthy lifestyles, especially taking proper exercise and sleeping, and avoidance of inhalant allergens during late pregnancy may be a more important strategy for the reduction of cord blood IgE levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007361013917
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  • 4
    Electronic Resource
    Electronic Resource
    Multiple photoionization from 3p excitation of Kr and 4p excitation of Xe (1986)
    Springer
    The European physical journal 4 (1986), S. 25-30 
    Details
    ISSN: 1434-6079
    Keywords: 32.30.Rj ; 33.80.Dz ; 33.80.Hd
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The photoionization cross sections for multiply charged ions produced by 3p excitation of Kr and 4p excitation of Xe have been obtained by means of a time-of-flight mass spectrometer and synchrotron radiation. It is found that the main formation of doubly to quadruply charged ions in both Kr and Xe is caused from the each initialp-hole state through a Coster-Kronig transition followed by Auger or double Auger processes. The formation of singly charged ions in these excitation energy regions is caused by direct photoionization from outermost shell electrons in both Kr and Xe. Triply charged ions are prominently produced among the multiply charged ions. The quadruple photoionization cross sections show clearly the structures due to the Rydberg series, 3p −1 nl of Kr and 4p −1 nl of Xe. Their main structures were assigned to the 3p −1 nd series in Kr and the 4p −1 nd series in Xe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01432495
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