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  • 1
    Electronic Resource
    Electronic Resource
    Critical soft tissue parameters of the zygomatic implant (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: Zygomatic implants have been introduced for the rehabilitation of patients with severe bone defects of the maxilla. The soft tissue aspects of the palatal emergence situation have not been described yet. The aim of this study was to evaluate the incidence and clinical impact of possible periimplant alterations of zygomatic implants.Materials and methods: From 1998 to 2001 all patients with zygomatic implants were included into this study (24 patients, 37 zygomatic implants). One implant was lost in the loading phase giving a survival rate of 97%. Fourteen patients with 20 zygomatic implants fulfilled the inclusion criteria and were all available for the recall examination. Thirteen zygomatic implants were inserted in cases of severe maxillary atrophy, seven in cases of tumour-resection of the maxilla. Clinical examination and microbial analysis using a DNA probe was performed. The implants had a mean time in situ of 598 days (min: 326, max: 914).Results: Colonisation with periodontal pathogens was found at four of the 20 implants. A positive microbiologic result of the periimplant pocket and the maximum pocket probing depth were not statistically related. Nine of the 20 implants showed bleeding on probing, four of these had positive microbiologic results. At sites without bleeding on probing only negative microbiologic samples were found (p=0.026). The mean palatal and mesial probing depth was 1 mm deeper than at the vestibular and distal aspect. Thus at nine out of the 20 implants both, bleeding on probing and pocket probing depth 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE505:ges" location="ges.gif"/〉5 mm indicated soft tissue problems resulting in a success rate of only 55%. The patient's history (tumor versus atrophy) or smoking habits seemed not to have influence the situation.Conclusion: These soft tissue problems should be taken into account if zygomatic implants are considered as an alternative therapy option in the maxilla.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00505.x
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  • 2
    Electronic Resource
    Electronic Resource
    In Vitro Activity of LY333328, a New Glycopeptide, against Extracellular and Intracellular Vancomycin-Resistant Enterococci (2000)
    Springer
    Infection 28 (2000), S. 214-218 
    Details
    ISSN: 1439-0973
    Keywords: Key Words LY333328 ; In vitro Activity ; Enterococci ; VRE ; Vancomycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objectives of the study were to observe the activity of LY333328, a new semisynthetic glycopeptide, compared to that of vancomycin against six strains of Enterococcus faecium and Enterococcus faecalis, including four vancomycin-resistant strains. Bacteria ingested by polymorphonuclear leukocytes (PMN) as well as extracellular bacteria were studied using a colony count method. The activity against intracellular bacteria was tested with the drugs present in the extracellular medium, as well as after preincubating the PMN and removal of the drugs. LY333328 is active against the tested enterococci, regardless of their susceptibility to vancomycin, with MICs of 1–2mg/l. It is bacteriostatic against extracellular enterococci at concentrations of 2 μg/ml and above regardless of their resistance to vancomycin. After 4 h incubation at 10 MIC, vancomycin-resistant strains of E. faecium and E. faecalis located intracellularly were reduced by 55% and 90%, respectively. Even after preincubation and removal of the drug, LY333328 had an effect at 10 MIC with a 20–30% reduction in the inoculum. The results suggest that in contrast to vancomycin, LY333328 is active against intracellular vancomycin-resistant enterococci, particularly E. faecalis, even after removal of the extracellular drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s150100070038
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  • 3
    Electronic Resource
    Electronic Resource
    Terminal end of the human odontoblast processes (2000)
    Springer
    Clinical oral investigations 4 (2000), S. 106-107 
    Details
    ISSN: 1436-3771
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007840050124
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  • 4
    Electronic Resource
    Electronic Resource
    Using ultrasound transmission velocity to analyse the mechanical properties of teeth after in vitro, in situ, and in vivo irradiation (2000)
    Springer
    Clinical oral investigations 4 (2000), S. 168-172 
    Details
    ISSN: 1436-3771
    Keywords: Key words Ultrasound ; Radiation caries ; Head and neck neoplasm ; Radiotherapy ; Modulus of elasticity ; Enamel ; Dentine ; In vitro ; In vivo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Ultrasound transmission velocity (UTV) in isotropic material as a measure for the modulus of elasticity was correlated to mechanical properties. Changes in micromechanical properties of radiated teeth and influence of the oral cavity were to be evaluated nondestructively. UTV was measured in extracted teeth after 36 Gy and 62 Gy of in situ (enorally, with no contact to the oral cavity) and in vitro irradiation. Relative to controls, teeth subjected to 62 Gy in vivo showed higher UTV values for dentine and enamel. Sound teeth irradiated with 60 Gy in situ also showed higher UTV values for enamel, whereas dentine values were not significantly different from those of control. The mechanical properties of teeth irradiated in vitro were affected only after high experimental doses of up to 500 Gy. The difference between in vivo and in vitro mechanical properties may be due to radioxerostomia-induced damages as well as the status of dentine vitality. This supports the concept of direct radiation-induced damage in synergy with radioxerostomia-induced caries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007840000068
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  • 5
    Electronic Resource
    Electronic Resource
    Treatment of injuries to the inferior alveolar nerve after endodontic procedures (1998)
    Springer
    Clinical oral investigations 2 (1998), S. 73-76 
    Details
    ISSN: 1436-3771
    Keywords: Key words Inferior alveolar nerve ; Complications ; Endodontic treatment ; Surgical therapy ; Apicectomia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Overextension of filling material into the mandibular canal after root treatment in the lower jaw is a rare but serious complication. Mechanical compression, chemical neurotoxicity and local infection may cause irreversible nerve damage. A report on 11 patients with neurological complaints of the inferior alveolar nerve after endodontic treatment is summarised. The neurological findings are dominated by hypaesthesia and dysaesthesia. Half of the patients reported pain. Hyperaesthesia is found much more rarely. Nearly all the patients had a combination of one or more symptoms. Initial X-rays showed root filling material in the area of the mandibular canal. Nine cases were treated with apicectomy and decompression of the nerve; in two cases, extraction of the tooth was necessary. Only one patient reported persistent pain after surgery. If neurological complaints appear after root filling in the lower jaw, a nerve injury due to root filling material should be ruled out. In cases of overfilling, immediate apicectomy and decompression of the nerve with conservation of the tooth is often the treatment of choice; the tooth may be preserved and the best chance of avoiding permanent nerve damage is provided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007840050048
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  • 6
    Electronic Resource
    Electronic Resource
    Confocal Laser Scanning Microscopy: A Nondestructive Subsurface Histotomography of Healthy Human Bone (1999)
    Springer
    Calcified tissue international 65 (1999), S. 8-10 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Microscopy — Confocal methods — Bone — Human — Osteocytes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Microscopy of bony tissue usually requires special treatment for decalcification and processing of thin sections. Confocal laser scanning microscopy (CLSM) allows the nondestructive histotomography of organic hard tissue. The aim of this study was to visualize healthy human bone structures and to correlate identical areas in CLSM and conventional light microscopy. Each sample of healthy human lower jaw (n = 20) was divided into three parts: (1) fresh, untreated bony blocks studied by CLSM; (2) MMA-embedded thin sections (without decalcification), HE stained and studied by CLSM and conventional light microscopy (correlation of identical areas); (3) decalcificated, HE stained, histological sections studied by conventional light microscopy. In untreated bony blocks, microstructures such as osteocytes and lamellae were identified by CLSM. These structures could be correlated with conventional light microscopy. In CLSM, subcellular structures cannot yet be interpreted, whereas cytoplastic processes of osteocytes were seen with high contrast. With CLSM, nondestructive histology of cortical bone can be obtained. The risk of artifacts due to pretreatment is minimized, and subsurface visualization does not affect the interpretation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900650
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  • 7
    Electronic Resource
    Electronic Resource
    Mikromorphologische Kieferveränderungen nach Bestrahlung (1999)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 3 (1999), S. 140-145 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Konfokale Laser-Scanning-Mikroskopie ; Dunkelfeldmikroskopie ; Bisbenzimidmarkierung ; Knochen ; Strahlenfolgen ; Radiogener Osteozytentod ; Key words Confocal laser scanning microscopy ; Microscopy ; Bisbenzimide labelling ; Bone ; Radiation effects ; Osteocytes ; Osteoradionecrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Early radiation effects on human bone may lead to osteoradionecrosis (ORN). Direct bone cellular lesions [28] as well as fibrous degeneration of blood vessels [21] are considered to be pathologically relevant. Only few data on initial subclinical radiation effects are available. Patients were grouped according to the dose of radiation and clinical findings. Group 1: sound human bone of lower jaw, mostly collected during orthodontic surgery (n = 10 patients); group 2: specimens of lower jaw from patients with ORN (n = 12 patients); group 3: specimens of lower jaw from patients with head and neck cancer who were preoperatively treated with 36 Gy radiation; group 4: specimens of lower jaw from patients with head and neck cancer (n = 9) who were treated with 60–70 Gy radiation. Specimens were studied by confocal laser scanning microscopy (CLSM), by conventional light microscopy (DL) and by flourescence darkfield microscopy (DFM) after bisbenzimide staining (H 33258) of the viable cellular nuclei. For the correlating study of identical areas in CLSM and DL the specimens were prepared according to the sawing and grinding technique [8]. All the radiated bony specimens, regardless of the dose of radiation, showed areas of extensive or total loss of vitality of the osteocytes. This finding was also evident after 36 Gy and a short interval between radiation and sample collection (group 3). Additionally, in CLSM micromorphologic lesions of the lamellate structure were seen. With these results we can confirm the loss of vitality of the osteocytes as an initial radiation effect as described earlier [10, 23, 28]. In addition to these findings, alteration of the lamellate microstructure was found in the early phase after radiation. The functional and mechanical significance of these findings should be the subject of further studies.
    Notes: Für die infizierte Osteoradionekrose (IORN) des Kiefers werden unterschiedliche pathogenetische Mechanismen initialer Strahlenfolgen im Knochen diskutiert: Wichtige Parameter sind dabei die direkte Zellschädigung der Osteozyten [28] und die Gefäßfibrosierung [21]. Bislang liegen wenige Kenntnisse zum Ausmaß der initialen, subklinischen Veränderungen vor. 4 Probengruppen wurden anhand verschiedener Patientenkollektive definiert: Gruppe 1: gesunde Unterkieferproben meist von orthodontischen Operationen (n = 10 Patienten); Gruppe 2: Unterkieferproben mit manifester IORN (n = 12 Patienten); Grruppe 3: Unterkieferproben nach 36 Gy präoperativer Radio(chemo)therapie (n = 9 Patienten); Gruppe 4: Unterkieferproben nach 60–70 Gy Bestrahlung ohne Hinweise auf IORN (n = 9 Patienten). Alle Proben wurden histotomographisch mit konfokaler Laser-Scanning-Mikroskopie (CLSM), durchlichtmikroskopisch (DL) und dunkelfeldmikroskopisch (DFM) nach Fluoreszenzmarkierung des intakten Zellkerns (Bisbenzimid H 33258) untersucht. Korrelierende Histologien identischer Probenareale erfolgten an Trenndünnschliffen [8]. Als Ergebnisse wurden gefunden: 1. Alle unterschiedlich bestrahlte Knochenproben zeigten Areale mit weitgehendem bis vollständigem Verlust vitaler Osteozyten. Diese Strahlenfolge trat auch schon nach 36 Gy und kurzem Intervall bis zur Operation (Gruppe 3) auf. 2. Im CLSM zeigten sich zusätzlich mikromorphologische Veränderungen der lamellären Struktur, die zwischen den Probengruppen progredient waren. Hieraus können folgende Schlußfolgerungen gezogen werden: 1. Der vorbeschriebene Vitalitätsverlust der Osteozyten [10, 23, 28] konnte als sehr frühe, initiale, radiogene Läsion bestätigt werden. 2. Zusätzlich zeigten sich Veränderungen der lamellären Mikroarchitektur des Knochens als frühe und im Gruppenvergleich progrediente Strahlenläsion. Die mikromechanisch funktionelle Bedeutung dieser Veränderung muß in weiterführenden Untersuchungen eruiert werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100060050118
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  • 8
    Electronic Resource
    Electronic Resource
    Prognose und Prognosefaktoren enossaler Implantate im bestrahlten Kiefer (1999)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 3 (1999), S. S117 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Kaufunktionelle Rehabilitation ; Enossale Implantate ; Strahlentherapie ; Prognosefaktoren ; Kaplan-Meier-Analyse ; Key words Rehabilitation of masticatory function ; Enossal implants ; Radiotherapy ; Factors affecting prognosis ; Kaplan-Meier Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In comparison to tumor patients not receiving radiotherapy, the rehabilitation of masticatory function after head and neck irradiation is limited due to radiation-induced caries, radioxerostomia, and the risk of osteoradionecrosis. This study focused on implants in the irradiated jaw and on the evaluation of the prognosis and the effect of potential factors on the prognosis. The retrospective study covered 197 implants (47 patients) from 1988 to 1997. The implant prognosis was determined by implant survival statistics (Kaplan-Meier). Losses not related to the implants were censored. In addition, groups were formed according to factors potentially affecting the prognosis. The significance of differences in the groups relative to survival were tested using the log-rank test. Twelve (6.1%) implants from a total of 197 were lost due to peri-implantitis, and eight (4.1%) due to possible biomechanical stress. A total of 52 losses (26.4%) due to death of patients and two (1.0%) due to resection of the jaw were censored; 111 (56.3%) implants remained at recall and the average interval was 33 months. The rates of implant survival (Kaplan-Meier) after 1 and 2 years were 95%, after 3 and 4 years 92%, and after 5 and 6 years 72%. The univariate analysis of group comparisons showed a significantly lower rate of loss after perimplant flap reconstruction (p = 0.036). There was no effect due to the doses of irradiation (p = 0.16), chemotherapy (p = 0.90), or peri-implant osteoplasty (p = 0.84). Although none of the implants inserted before radiotherapy had to be explanted, the implant survival difference in the very heterogeneous groups was not significant (preirradiation, n = 29; postirradiation: n = 156; p = 0.13). According to the literature, the rate of survival of teeth which were sound before radiotherapy (1 year, 75%; 5 years, 45%) was distinctly lower than the survival of enossal implants (1 year, 95%; 5 years, 72%). The high-quality rehabilitation of masticatory function with implant-based protheses is the preferred method of treatment for irradiated tumor patients. In addition, contraindications for enossal implants were ruled out for all studied factors affecting prognosis.
    Notes: Zusammenfassung Einleitung: Die kaufunktionelle Wiederherstellung nach Kopf-Hals-Bestrahlung ist gegenüber anderen Tumorpatienten durch Strahlenkaries, Radioxerostomie und Osteoradionekroserisiko zusätzlich limitiert. Es wurde der Frage der Implantatprognose und potentieller Prognosefaktoren im bestrahlten Kiefer nachgegangen. Material und Methode: Die retrospektive Studie erfaßte von 1988–1997 197 Implantate (47 Patienten). Die Implantatprognose wurde durch Überlebenszeitanalyse (Kaplan-Meier) bestimmt, wobei implantatunabhängige Verluste zensiert wurden. Außerdem erfolgte eine Gruppenbildung nach potentiell die Prognose beeinflussenden Parametern. Grupppenunterschiede in den Überlebensraten wurden mit dem Log-Rank-Test auf Signifikanz geprüft. Ergebnisse: Von 197 Implantaten gingen 12 (6,1%) durch Periimplantitis und 8 (4,1%) durch mögliche biomechanische Überlastung verloren. Zensiert wurden 52 Verluste (26,4%) wegen Versterbens und 2 (1,0%) wegen Kieferresektion. 111 Implantate (56,3%) verblieben im Recall; die gemittelte Nachkontrollphase betrug 33 Monate. Die Überlebensrate (Kaplan-Meier-Analyse) betrug nach 1 und 2 Jahren 95%, nach 3 und 4 Jahren 92% und nach 5 und 6 Jahren 72%. Die univariate Analyse der Gruppenvergleiche zeigte eine lokal signifikant niedrigere Verlustrate nach periimplantärer Weichteilplastik (p = 0,036). Bestrahlungsdosis (p = 0,16), Chemotherapie (p = 0,9) und periimplantäre Osteoplastik (p = 0,84) beeinflußten die Prognose nicht. Obwohl kein vor der Bestrahlung gesetztes Implantat explantiert wurde, war der Unterschied bei sehr inhomogenen Gruppenstärken (prä radiationem: n = 29; post radiationem: n = 156) nicht signifikant (p = 0,13). Schlußfolgerungen: Im Literaturvergleich ist die Überlebensrate prae radiationem gesunder Zähne (1 Jahr: 75%; 5 Jahre: 45%) deutlich schlechter als die Prognose enossaler Implantate (1 Jahr: 95%; 5 Jahre: 72%). Die funktionell hochwertige Restitutio des Kauorgans durch implantatgetragenen Zahnersatz ist damit auch für bestrahlte Tumorpatienten bestätigt. Eine Kontraindikation enossaler Implantation konnte daneben für alle untersuchten zusätzlichen Prognosefaktoren ausgeschlossen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014497
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  • 9
    Electronic Resource
    Electronic Resource
    Retrospektive Analyse zur prognostischen Bedeutung der Art der Unterkieferresektion und einer adjuvanten Strahlentherapie bei unterkiefernahen Karzinomen (2000)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 301-308 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Mundhöhlenkarzinom Prognosefaktoren ; Unterkieferresektion ; Strahlentherapie ; Keywords Oral carcinoma ; Prognostic factors ; Mandibular resection ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The prognostic effect of bone resection (continuous vs non-continuous) was analysed in a retrospective study of 100 patients who were treated for squamous cell carcinoma located close to the lower jaw, between 1983 and 1994. Tumour stage, type of bone resection, extent of lymphatic node resection, dose of radiotherapy and chemotherapy were documented. Prognosis was characterised by the statistical end points “death”, “metastasis” and “relapse”. Thirty-two stage pT2 carcinomas, half of which were treated by continuous and half by non-continuous resection of the lower jaw, showed the same occurrence of the statistical end points death, metastasis or relapse. There was a trend towards a significantly longer survival time and metastasis-free interval in the group of continuous resection. The hazard ratios, however, showed no effect depending on the type of resection. However, both tumour stage (pTNM) and dose of radiation independently influenced prognosis in multivariate analysis. Consequently, three groups were defined. Univariate analysis of 62 patients without radiotherapy vs 19 with low-dose radiotherapy (36 Gy) and 19 with high-dose (62 Gy) showed a positive effect on the rate and time of survival in the group treated with high-dose radiotherapy. This was confirmed by multivariate analysis showing significantly lower hazard ratios for death and metastasis in the high-dose radiotherapy group after adjusting to cofactors (e.g. tumour stage). The data of this study challenge the current concept of resection of the lower jaw. However, due to the low number of patients and the retrospective character of the study, it is not possible to give suggestions regarding established therapy concepts. The advances of a high-dose radiotherapy in this study should be the subject of further multicentre retrospective and prospective randomised trials.
    Notes: Zusammenfassung Durch die retrospektive Auswertung von 100 Patienten mit unterkiefernahen Karzinomen (1983–1994) sollte eruiert werden, inwieweit die Art der Unterkieferresektion (Kasten- vs. Kontinuitätsresektion) den Erkrankungsverlauf prognostisch beeinflusst. Als potenziell prognosebeeinflussende Parameter wurden das Tumorstadium, der Unterkieferresektionsmodus, der Umfang der Lymphknotendissektion, die Strahlentherapiedosis und die Chemotherapie einbezogen. Zur Prognosebewertung dienten die Endpunkte „Versterben“, „Metastase“ und „Rezidiv“. 32 pT2-Karzinome, die jeweils zur Hälfte kasten- bzw. kontinuitätsreseziert wurden, zeigten bezüglich der Endpunkte „Versterben“, „Metastase“ und „Rezidiv“ gleiche Ereignisquoten. Überlebenszeiten und Metastasenfreiheitszeiten (Kaplan-Meier) verwiesen univariat auf einen tendenziellen Vorteil der Kontinuitätsresektion. Die relativen Risiken ergaben dagegen keinen Hinweis auf einen relevanten Effekt der Resektionsform. Da sich in ¶der multivariaten Analyse neben dem pTNM-Stadium die Bestrahlungsdosis als unabhängiger Prognosefaktor präsentierte, wurden hierzu zusätzlich ¶3 Gruppen gebildet. Der Vergleich von 62 nicht strahlentherapierten Patienten gegenüber 19 niedrig dosiert ¶(36 Gy) und 19 hoch dosiert (63 Gy) Bestrahlten zeigte univariat in den Überlebenszeiten einen Vorteil nach Ausbestrahlung. Dieser Vorteil wurde multivariat durch ein signifikant geringeres relatives Risiko für „Versterben“ und „Metastase“ nach Ausbestrahlung bestätigt. Die diskordante Datenlage der Studie zur Unterkieferresektion ist keine verlässliche Basis, eine Therapieempfehlung zu stützen, die vom etablierten Konzept abweicht. Bei aller Zurückhaltung aufgrund der retrospektiven und monozentrischen Ergebniseruierung kann aber ein Hinweis auf einen möglichen relevanten Prognosevorteil durch eine hochdosierte, adjuvante Bestrahlung abgeleitet werden, der multizentrisch retrospektiv und ggf. in prospektiven, randomisierten Studien geprüft werden sollte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100060000221
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  • 10
    Electronic Resource
    Electronic Resource
    Procalcitonin in patients with and without immunosuppression and sepsis (1996)
    Springer
    Infection 24 (1996), S. 434-436 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Patienten mit Sepsis oder schweren Infektionen sind erhöhte Werte des Hormons Procalcitonin (PCT) beschrieben worden. In einer prospektiven Studie wurde PCT im Serum von 122 erwachsenen Patienten mit Sepsis, die in der Abteilung für Innere Medizin hospitalisiert waren, am Tag der Aufnahme und bis zu 9 Tage danach bestimmt. Patienten mit intaktem Immunsystem hatten bis zum 5. Tag erhöhte PCT-Werte, die sich bis zum 9. Tag normalisierten. Patienten mit Sepsis und Immundefizienz hatten am Tag 0 bis 2 ebenfalls erhöhte Werte. Sie wiesen jedoch an den folgenden 3 Tagen signifikant niedrigere Werte auf als die Patienten der ersten Gruppe. Die PCT-Konzentrationen gingen am Tag 6 bis 9 der Sepsisepisode in beiden Gruppen auf Normalwerte zurück. Der beobachtete Unterschied der PCT-Konzentrationen stand weder in signifikantem Zusammenhang mit der Art des Mikroorganismus, der die Sepsis verursachte, noch mit einer Sepsis mit negativer Blutkultur. Eine Leukopenie scheint mit niedrigeren PCT-Werten am Tag 2 der Sepsisepisode einherzugehen, dies konnte jedoch nicht statistisch bewiesen werden.
    Notes: Summary High serum levels of procalcitonin (PCT) are observed in patients with sepsis or severe infection. In a prospective study of 122 hospitalised adult medical patients with sepsis, serum PCT was determined on admission and for 9 days thereafter. Patients with no alteration in their immune system showed high PCT values up to day 5, decreasing to normal levels by day 9. Patients with sepsis and immunodeficiency had high values on days 0 to 2, similar to the first group, but showed significantly lower levels on the following 3 days. PCT concentrations fell to base line levels on days 6 to 9 of the sepsis episode in both groups. The observed difference was not significantly related to the kind of causative microorganism or a culture negative sepsis. Leukopenia seemed to go together with lower PCT values after day 2 of the episode, but this could not be proven statistically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713044
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