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  • 1
    ISSN: 0340-1855
    Keywords: Schlüsselwörter¶Klinische Studien –¶Entzündungstherapie ; Key words Clinical studies –¶inflammation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The most important aim of the center is the development of an innovative structure for organizing clinical research in order to define quickly a large number of patients and include them in special studies that will be carried out with high clinical quality and competence. To this end, special competence networks in which clinical doctors of the university and private doctors will be organized to cooperate in the field of clinical studies.
    Notes: Zusammenfassung Wesentliches Ziel des Zentrums ist die Entwicklung einer innovativen Organisationsstruktur für die klinische Forschung, mit deren Hilfe rasch große Patientenzahlen definiert und für spezielle Studien erfaßt werden können, die mit hoher klinischer Qualität und Kompetenz durchgeführt werden. Zu diesem Zweck haben wir fachbezogene Kompetenznetzwerke geschaffen, in denen Klinikärzte des Universitätsklinikums und niedergelassene Fachärzte bei der Durchführung von klinischen Studien kooperieren.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-9949
    Keywords: Key words:Cytomegalovirus – Diagnostic category – Herpes simplex virus – Monoarthritis – Oligoarthritis – Parvovirus B19 – Polymerase chain reaction – Synovial tissue – Undifferentiated arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A common problem in rheumatological practice is inflammatory joint disease that cannot be classified. The prognosis of such undifferentiated arthritides is uncertain. The synovial tissue of 41 consecutive patients with various forms of arthritis was tested for the presence of viral DNA in a diagnosis-unaware fashion, using the polymerase chain reaction (PCR). Of all tested viruses, cytomegalovirus and parvovirus B19 were positive (each in 10 patients, two double-positives), whereas herpes simplex virus was positive in two patients. Rubella virus RNA was detected in three specimens. When the positivity for viral material was analysed in terms of distribution among the various diagnostic groups, it became evident that five out of 10 parvovirus B19-positive patients belonged to the undifferentiated arthritis group, whereas cytomegalovirus-positive patients were spread among all diagnostic groups. This indicates the possibility of a new diagnostic category of undifferentiated mono- and oligoarthritis, which can be identified by the presence of parvovirus B19 DNA in synovial tissue.
    Type of Medium: Electronic Resource
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