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  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 40 (2002), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Recession curves contain information on storage properties and different types of media such as porous, fractured, cracked lithologies and karst. Recession curve analysis provides a function that quantitatively describes the temporal discharge decay and expresses the drained volume between specific time limits (Hall 1968). This analysis also allows estimating the hydrological significance of the discharge function parameters and the hydrological properties of the aquifer. In this study, we analyze data from perennial springs in the Judean Mountains and from others in the Galilee Mountains, northern Israel. All the springs drain perched carbonate aquifers. Eight of the studied springs discharge from a karst dolomite sequence, whereas one flows out from a fractured, slumped block of chalk. We show that all the recession curves can be well fitted by a function that consists of two exponential terms with exponential coefficients α1 and α2. These coefficients are approximately constant for each spring, reflecting the hydraulic conductivity of different media through which the ground water flows to the spring. The highest coefficient represents the fast flow, probably through cracks, or quickflow, whereas the lower one reflects the slow flow through the porous medium, or baseflow. The comparison of recession curves from different springs and different years leads to the conclusion that the main factors that affect the recession curve exponential coefficients are the aquifer lithology and the geometry of the water conduits therein. In normal years of rainy winter and dry summer, α1 is constant in time. However, when the dry period is longer than usual because of a dry winter, α1 slightly decreases with time.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7217
    Keywords: breast cancer ; first degree relatives ; peripheral blood lymphocytes ; chromosome analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Many genetic abnormalities disclosed even in somatic cells like peripheral blood lymphocytes may mark footprint(s) of malignancy(ies). The present cytogenetic study on peripheral blood lymphocytes of sporadic breast cancer patients (n = 20) and their first degree relatives (n = 39) reports abnormalities of chromosomes 16, 5, 12, and 17 respectively in 17.59%, 8.33%, 6.48%, and 5.57% cells of patients and 15.83%, 8.33%, 7.5%, and 5% cells of their first degree relatives. These common chromosomal abnormalities pave the way to assume why first degree relatives of sporadic breast cancer patients are at increased risk of developing the same or other malignancies.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 283-288 
    ISSN: 1432-1335
    Keywords: Areca nut ; Arecoline ; Sister chromatid exchange ; Chromosome aberrations ; Genotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The genotoxic potential of the aqueous extract of areca nut as well as arecoline, the major alkaloid of the areca nut, was tested with the help of cytogenetic markers such as sister-chromatid exchanges and chromosome aberrations, utilizing Chinese hamster ovary (CHO) cells. The continuous-treatment and pulse-treatment schedules yielded dose-dependent elevations in the frequencies of sister-chromatid exchange and chromosomal aberration in CHO cells, indicating a genotoxic effect of both the extract and arecoline. The results also imply that, besides arecoline, there may be some other water-extractable substances in the areca nut that make the extract more genotoxic. The chromosome damage was found to be more severe on treating the cells with low concentrations and for longer duration, which mimic the effects of chronic areca nut consumption.
    Type of Medium: Electronic Resource
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